ADAM12 induces estrogen-independence in breast cancer cells

Breast Cancer Research and Treatment

Volumn 131, Issue 3, 2012, Pages 731-741

  Roy, Roopali ^a,b   Moses, Marsha A ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

ADAM; Amphiregulin; Antiestrogen resistance; Breast tumor proliferation; EGFR; Metalloprotease

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; ADAM PROTEIN; ADAM12 PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ESTROGEN; FULVESTRANT; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PD 15035; PROTEIN ADAM12 L; PROTEIN ADAM12 S; SOMATOMEDIN C RECEPTOR; TAMOXIFEN; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER HORMONE THERAPY; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ENZYME ACTIVATION; ESTROGEN ACTIVITY; HORMONE RESISTANCE; HORMONE RESPONSE; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TUMOR GROWTH; TUMOR RESISTANCE; UPREGULATION;

ADAM PROTEINS; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG RESISTANCE, NEOPLASM; ESTROGENS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; MEMBRANE PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TAMOXIFEN;

EID: 84856225258     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-011-1431-4     Document Type: Article

References (36)

1. PM Ravdin KA Cronin N Howlader CD Berg RT Chlebowski EJ Feuer BK Edwards DA Berry 2007 The decrease in breast-cancer incidence in 2003 in the united states N Engl J Med 356 16 1670 1674 10.1056/NEJMsr070105 17442911 10.1056/NEJMsr070105 1:CAS:528:DC%2BD2sXksFCltL0%3D
2. CK Osborne SA Fuqua 1994 Mechanisms of tamoxifen resistance Breast Cancer Res Treat 32 1 49 55 7819585 10.1007/BF00666205 1:CAS:528:DyaK2MXitFGmt7c%3D
3. K McCune P Bhat-Nakshatri MA Thorat KP Nephew S Badve H Nakshatri 2010 Prognosis of hormone-dependent breast cancers: implications of the presence of dysfunctional transcriptional networks activated by insulin via the immune transcription factor t-bet Cancer Res 70 2 685 696 10.1158/0008-5472.CAN-09-1530 20068169 10.1158/0008-5472.CAN-09-1530 1:CAS:528:DC%2BC3cXltlWqug%3D%3D
4. S Masri Z Liu S Phung E Wang YC Yuan S Chen 2010 The role of microrna-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells Breast Cancer Res Treat 10.1007/s10549-009-0716-3 20054641
5. T Frogne RV Benjaminsen K Sonne-Hansen BS Sorensen E Nexo AV Laenkholm LM Rasmussen DJ Riese 2nd P de Cremoux J Stenvang AE Lykkesfeldt 2009 Activation of ErbB3, EGFR and ERK is essential for growth of human breast cancer cell lines with acquired resistance to fulvestrant Breast Cancer Res Treat 114 2 263 275 10.1007/s10549-008-0011-8 18409071 10.1007/s10549-008-0011-8 1:CAS:528:DC%2BD1MXhsFWnu74%3D
6. Sonne-Hansen K, Norrie IC, Emdal KB, Benjaminsen RV, Frogne T, Christiansen IJ, Kirkegaard T, Lykkesfeldt AE (2009) Breast cancer cells can switch between estrogen receptor alpha and erbb signaling and combined treatment against both signaling pathways postpones development of resistance. Breast Cancer Res Treat. doi: 10.1007/s10549-009-0506-y
7. SE Ghayad JA Vendrell SB Larbi C Dumontet I Bieche PA Cohen 2009 Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/AKT signaling pathways Int J Cancer 126 2 545 562 10.1002/ijc.24750 10.1002/ijc.24750
8. K Iba R Albrechtsen BJ Gilpin F Loechel UM Wewer 1999 Cysteine-rich domain of human ADAM12 (meltrin alpha) supports tumor cell adhesion Am J Pathol 154 5 1489 1501 10329602 10.1016/S0002-9440(10)65403-X 1:CAS:528: DyaK1MXjtl2hsr4%3D
9. M Asakura M Kitakaze S Takashima Y Liao F Ishikura T Yoshinaka H Ohmoto K Node K Yoshino H Ishiguro H Asanuma S Sanada Y Matsumura H Takeda S Beppu M Tada M Hori S Higashiyama 2002 Cardiac hypertrophy is inhibited by antagonism of adam12 processing of hb-egf: metalloproteinase inhibitors as a new therapy Nat Med 8 1 35 40 10.1038/nm0102-35nm0102-35[pii] 11786904 10.1038/nm0102-35 1:CAS:528:DC%2BD38Xjtlyhug%3D%3D
10. K Horiuchi HM Zhou K Kelly K Manova CP Blobel 2005 Evaluation of the contributions of adams 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2 Dev Biol 283 2 459 471 S0012-1606(05)00298-8[pii]10.1016/j.ydbio.2005.05.004 15936750 10.1016/j.ydbio.2005.05.004 1:CAS:528:DC%2BD2MXmt1ejsLg%3D
11. E Dyczynska D Sun H Yi A Sehara-Fujisawa CP Blobel A Zolkiewska 2007 Proteolytic processing of delta-like 1 by adam proteases J Biol Chem 282 1 436 444 10.1074/jbc.M605451200 17107962 10.1074/jbc.M605451200 1:CAS:528: DC%2BD2sXkslSl
12. N Ito S Nomura A Iwase T Ito F Kikkawa M Tsujimoto S Ishiura S Mizutani 2004 Adams, a disintegrin and metalloproteinases, mediate shedding of oxytocinase Biochem Biophys Res Commun 314 4 1008 1013 14751233 10.1016/j.bbrc.2003.12.183 1:CAS:528:DC%2BD2cXntVGntg%3D%3D
13. F Loechel BJ Gilpin E Engvall R Albrechtsen UM Wewer 1998 Human adam 12 (meltrin alpha) is an active metalloprotease J Biol Chem 273 27 16993 16997 9642263 10.1074/jbc.273.27.16993 1:CAS:528:DyaK1cXkt12msrg%3D
14. F Loechel JW Fox G Murphy R Albrechtsen UM Wewer 2000 Adam 12-s cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3 Biochem Biophys Res Commun 278 3 511515 10.1006/bbrc.2000.3835S0006-291X(00)93835-X[pii] 10.1006/bbrc.2000.3835
15. R Roy UM Wewer D Zurakowski SE Pories MA Moses 2004 Adam 12 cleaves extracellular matrix proteins and correlates with cancer status and stage J Biol Chem 279 49 51323 51330 15381692 10.1074/jbc.M409565200 1:CAS:528: DC%2BD2cXhtVaqsrfL
16. M Kveiborg C Frohlich R Albrechtsen V Tischler N Dietrich P Holck P Kronqvist F Rank AM Mercurio UM Wewer 2005 A role for adam12 in breast tumor progression and stromal cell apoptosis Cancer Res 65 11 4754 4761 10.1158/0008-5472.CAN-05-0262 15930294 10.1158/0008-5472.CAN-05-0262 1:CAS:528:DC%2BD2MXks1Ohur4%3D
17. M Kveiborg R Albrechtsen JR Couchman UM Wewer 2008 Cellular roles of adam12 in health and disease Int J Biochem Cell Biol 40 9 1685 1702 10.1016/j.biocel.2008.01.025 18342566 10.1016/j.biocel.2008.01.025 1:CAS:528:DC%2BD1cXnsF2msbs%3D
18. U Lendeckel J Kohl M Arndt S Carl-McGrath H Donat C Rocken 2005 Increased expression of adam family members in human breast cancer and breast cancer cell lines J Cancer Res Clin Oncol 131 1 41 48 10.1007/s00432-004-0619-y 15565459 10.1007/s00432-004-0619-y 1:CAS:528:DC%2BD2cXhtVWjt7zP
19. C Frohlich R Albrechtsen L Dyrskjot L Rudkjaer TF Orntoft UM Wewer 2006 Molecular profiling of adam12 in human bladder cancer Clin Cancer Res 12 24 7359 7368 10.1158/1078-0432.CCR-06-1066 17189408 10.1158/1078-0432.CCR-06-1066
20. T Kodama E Ikeda A Okada T Ohtsuka M Shimoda T Shiomi K Yoshida M Nakada E Ohuchi Y Okada 2004 Adam12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor Am J Pathol 165 5 1743 1753 15509542 10.1016/S0002-9440(10)63429-3 1:CAS:528:DC%2BD2cXhtVCgsb3K
21. S Carl-McGrath U Lendeckel M Ebert A Roessner C Rocken 2005 The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer Int J Oncol 26 1 17 24 15586220 1:CAS:528:DC%2BD2MXmsFWjsQ%3D%3D
22. J Markowski M Oczko-Wojciechowska T Gierek M Jarzab J Paluch M Kowalska Z Wygoda A Pfeifer T Tyszkiewicz B Jarzab I Niedzielska H Borgiel-Marek 2009 Gene expression profile analysis in laryngeal cancer by high-density oligonucleotide microarrays J Physiol Pharmacol 60 Suppl 1 57 63 19609014
23. N Mino R Miyahara E Nakayama T Takahashi A Takahashi S Iwakiri M Sonobe K Okubo T Hirata A Sehara H Date 2009 A disintegrin and metalloprotease 12 (adam12) is a prognostic factor in resected pathological stage i lung adenocarcinoma J Surg Oncol 100 3 267 272 10.1002/jso.21313 19544357 10.1002/jso.21313 1:CAS:528:DC%2BD1MXhtFCgsL%2FI
24. H Le Pabic D Bonnier UM Wewer A Coutand O Musso G Baffet B Clement N Theret 2003 Adam12 in human liver cancers: Tgf-beta-regulated expression in stellate cells is associated with matrix remodeling Hepatology 37 5 1056 1066 10.1053/jhep.2003.50205S0270913903002544[pii] 12717386 10.1053/jhep.2003.50205 1:CAS:528:DC%2BD3sXktVWns7c%3D
25. SE Pories D Zurakowski R Roy CC Lamb S Raza A Exarhopoulos RG Scheib S Schumer C Lenahan V Borges GW Louis A Anand N Isakovich J Hirshfield-Bartek U Wewer MM Lotz MA Moses 2008 Urinary metalloproteinases: Noninvasive biomarkers for breast cancer risk assessment Cancer Epidemiol Biomarkers Prev 17 5 1034 1042 10.1158/1055-9965.EPI-07-0365 18483323 10.1158/1055-9965.EPI-07-0365 1:CAS:528:DC%2BD1cXmtVClsL8%3D
26. Roy R BD, Rodig S, Moses M (2010) Adam12 long and short isoforms promote breast tumor growth and metastasis via distinct mechanisms [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; Apr 17-21; Washington, DC Philadelphia (PA) Abstract nr 416
27. KR Coser BS Wittner NF Rosenthal SC Collins A Melas SL Smith CJ Mahoney K Shioda KJ Isselbacher S Ramaswamy T Shioda 2009 Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor Proc Natl Acad Sci USA 106 34 14536 14541 10.1073/pnas.0907560106 19706540 10.1073/pnas.0907560106 1:CAS:528: DC%2BD1MXhtFWku7vN
28. JM Knowlden IR Hutcheson HE Jones T Madden JM Gee ME Harper D Barrow AE Wakeling RI Nicholson 2003 Elevated levels of epidermal growth factor receptor/c-erbb2 heterodimers mediate an autocrine growth regulatory pathway in tamoxifen-resistant mcf-7 cells Endocrinology 144 3 1032 1044 12586780 10.1210/en.2002-220620 1:CAS:528:DC%2BD3sXhslCqtro%3D
29. M Bos J Mendelsohn YM Kim J Albanell DW Fry J Baselga 1997 Pd153035, a tyrosine kinase inhibitor, prevents epidermal growth factor receptor activation and inhibits growth of cancer cells in a receptor number-dependent manner Clin Cancer Res 3 11 2099 2106 9815602 1:CAS:528:DyaK2sXns1OgtrY%3D
30. N Eckstein K Servan L Girard D Cai G von Jonquieres U Jaehde MU Kassack AF Gazdar JD Minna HD Royer 2008 Epidermal growth factor receptor pathway analysis identifies amphiregulin as a key factor for cisplatin resistance of human breast cancer cells J Biol Chem 283 2 739 750 10.1074/jbc.M706287200 17942395 10.1074/jbc.M706287200 1:CAS:528:DC%2BD1cXhsFejtg%3D%3D
31. RM Adam J Kim J Lin A Orsola L Zhuang DC Rice MR Freeman 2002 Heparin-binding epidermal growth factor-like growth factor stimulates androgen-independent prostate tumor growth and antagonizes androgen receptor function Endocrinology 143 12 4599 4608 12446587 10.1210/en.2002-220561 1:CAS:528:DC%2BD38Xpt1eltrw%3D
32. SS Larsen M Egeblad M Jaattela AE Lykkesfeldt 1999 Acquired antiestrogen resistance in mcf-7 human breast cancer sublines is not accomplished by altered expression of receptors in the erbb-family Breast Cancer Res Treat 58 1 41 56 10634517 10.1023/A:1006232830161 1:CAS:528:DC%2BD3cXmsV2htA%3D%3D
33. A de Fazio YE Chiew RL Sini PW Janes RL Sutherland 2000 Expression of c-erbb receptors, heregulin and oestrogen receptor in human breast cell lines Int J Cancer 87 4 487 498 10.1002/1097-0215(20000815)87:4<487::AID-IJC5>3. 0.CO;2-J 10.1002/1097-0215(20000815)87:4<487::AID-IJC5>3.0.CO;2-J
34. N Rocks C Estrella G Paulissen F Quesada-Calvo C Gilles MM Gueders C Crahay JM Foidart P Gosset A Noel DD Cataldo 2008 The metalloproteinase adam-12 regulates bronchial epithelial cell proliferation and apoptosis Cell Prolif 41 6 988 1001 10.1111/j.1365-2184.2008.00557.x 19040574 10.1111/j.1365-2184.2008. 00557.x 1:CAS:528:DC%2BD1MXmt1yntg%3D%3D
35. A Okada S Mochizuki T Yatabe T Kimura T Shiomi Y Fujita H Matsumoto A Sehara-Fujisawa Y Iwamoto Y Okada 2008 Adam-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage Arthritis Rheum 58 3 778 789 10.1002/art.23262 18311789 10.1002/art.23262 1:CAS:528:DC%2BD1cXjslWqu70%3D
36. TL Wood MM Richert MA Stull MA Allar 2000 The insulin-like growth factors (IGFs) and IGF binding proteins in postnatal development of murine mammary glands J Mammary Gland Biol Neoplasia 5 1 31 42 10791766 10.1023/A:1009511131541 1:STN:280:DC%2BD3c3ltVChug%3D%3D