Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 3, 2012, Pages 1448-1454

  Edink, Ewald ^a   Akdemir, Atilla ^b   Jansen, Chimed ^a   Elk, René Van ^c   Zuiderveld, Obbe ^a   De Kanter, Frans J J ^c   Van Muijlwijk Koezen, Jacqueline E ^a   Smit, August B ^c   Leurs, Rob ^a   De Esch, Iwan J P ^a  

^a AMSTERDAM INSTITUTE FOR MOLECULES   (Netherlands)

^b BEZMIALEM VAKIF UNIVERSITY   (Turkey)

^c VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

AChBP; Fragment merging; Hit optimization; nAChR; Structure based design

Indexed keywords

ACETYLCHOLINE BINDING PROTEIN; NICOTINIC RECEPTOR; PROTEIN; TROPANE DERIVATIVE; TROPINE BENZOATE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; COMPUTER MODEL; DRUG SYNTHESIS; ENANTIOSELECTIVITY; LIGAND BINDING; PROCESS OPTIMIZATION; PROTEIN BINDING; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION;

BENZTROPINE; CAPRYLATES; CARRIER PROTEINS; DICARBOXYLIC ACIDS; DRUG DESIGN; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84856220939     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.008     Document Type: Article

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