Fragment based discovery of a novel and selective PI3 kinase inhibitor

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 21, 2011, Pages 6586-6590

  Hughes, Samantha J ^a   Millan, David S ^a   Kilty, Iain C ^a   Lewthwaite, Russell A ^a   Mathias, John P ^a   Reilly, Mark A O ^a   Pannifer, Andrew ^a   Phelan, Anne ^a   Stühmeier, Frank ^a   Baldock, Darren A ^a   Brown, David G ^a  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Fragment; Kinase

Indexed keywords

AMINO IMIDAZOPYRIDINE; IMIDAZOPYRIDINE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; LIVER MICROSOME; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

EID: 80054778774     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.07.117     Document Type: Article

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