Macrophage expression of LRP1, a receptor for apoptotic cells and unopsonized erythrocytes, can be regulated by glucocorticoids

Biochemical and Biophysical Research Communications

Volumn 417, Issue 4, 2012, Pages 1304-1309

  Nilsson, Anna ^a   Vesterlund, Liselotte ^b   Oldenborg, Per Arne ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Apoptotic cells; Efferocytosis; Inflammation; Macrophages

Indexed keywords

DEXAMETHASONE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MIFEPRISTONE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW; FEMALE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ANIMALS; ANTIGENS, CD47; APOPTOSIS; DEXAMETHASONE; ERYTHROCYTES; FEMALE; GLUCOCORTICOIDS; LDL-RECEPTOR RELATED PROTEIN-ASSOCIATED PROTEIN; MACROPHAGES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED BALB C; MIFEPRISTONE; PHAGOCYTOSIS; RECEPTORS, GLUCOCORTICOID; RECEPTORS, LDL; TUMOR SUPPRESSOR PROTEINS;

EID: 84856220918     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.12.137     Document Type: Article

References (16)

1. Gardai S.J., McPhillips K.A., Frasch S.C., Janssen W.J., Starefeldt A., Murphy-Ullrich J.E., Bratton D.L., Oldenborg P.A., Michalak M., Henson P.M. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 2005, 123:321-334.
2. Giles K.M., Ross K., Rossi A.G., Hotchin N.A., Haslett C., Dransfield I. Glucocorticoid augmentation of macrophage capacity for phagocytosis of apoptotic cells is associated with reduced p130Cas expression, loss of paxillin/pyk2 phosphorylation, and high levels of active. Rac. J. Immunol. 2001, 167:976-986.
3. Hertz J., Strickland D.K. LRP: a multifunctional scavenger and signaling receptor. J. Clin. Invest. 2001, 108:779-784.
4. Kancha R.K., Hussain M.M. Up-regulation of the low density lipoprotein receptor-related protein by dexamethasone in HepG2 cells. Biochim. Biophys. Acta 1996, 1301:213-220.
5. liu Y., Cousin J.M., Hughes J., Van Damme J., Seckl J.R., Haslett C., Dransfield I., Savill J., Rossi A.G. Glucocorticoids promote nonphlogistic phagocytosis of apoptotic leukocytes. J. Immunol. 1999, 162:3639-3646.
6. Marzolo M.P., von B.R., Bu G., Inestrosa N.C. Expression of alpha(2)-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells. J. Neurosci. Res. 2000, 60:401-411.
7. McColl A., Bournazos S., Franz S., Perretti M., Morgan B.P., Haslett C., Dransfield I. Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages. J. Immunol. 2009, 183:2167-2175.
8. Nilsson A., Oldenborg P.A. CD47 promotes both phosphatidylserine-independent and phosphatidylserine-dependent phagocytosis of apoptotic murine thymocytes by non-activated macrophages. Biochem. Biophys. Res. Commun. 2009, 387:58-63.
9. Ogden C.A., deCathelineau A., Hoffmann P.R., Bratton D., Ghebrehiwet B., Fadok V.A., Henson P.M. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J. Exp. Med. 2001, 194:781-795.
10. Oldenborg P.-A., Zheleznyak A., Fang Y.-F., Lagenaur C.F., Gresham H.D., Lindberg F.P. Role of CD47 as a marker of self on red blood cells. Science 2000, 288:2051-2054.
11. Savill J., Dransfield I., Gregory C., Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat. Rev. Immunol 2002, 2:965-975.
12. Schleimer R.P. An overview of glucocorticoid anti-inflammatory actions. Eur. J. Clin. Pharmacol. 1993, 45(Suppl 1):S3-S7.
13. Stahn C., Lowenberg M., Hommes D.W., Buttgereit F. Molecular mechanisms of glucocorticoid action and selective glucocorticoid receptor agonists. Mol. Cell Endocrinol. 2007, 275:71-78.
14. Tada K., Tanaka M., Hanayama R., Miwa K., Shinohara A., Iwamatsu A., Nagata S. Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1. J. Immunol. 2003, 171:5718-5726.
15. Vandivier R.W., Ogden C.A., Fadok V.A., Hoffmann P.R., Brown K.K., Botto M., Walport M.J., Fisher J.H., Henson P.M., Greene K.E. Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J. Immunol. 2002, 169:3978-3986.
16. Wang X., Li Y., Zhu X., Wang Y., Diao F., Lu J. Signal regulatory protein alpha1 is involved in the inhibitory effect of glucocorticoid receptor on the proliferation of murine macrophage RAW264.7 cell and mouse peritoneal macrophage. J. Mol. Endocrinol. 2008, 41:393-403.