Discovery of 7-arylsulfonyl-1,2,3,4, 4a,9a-hexahydro-benzo[4,5]furo[2,3-c] pyridines: Identification of a potent and selective 5-HT 6 receptor antagonist showing activity in rat social recognition test

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 3, 2012, Pages 1421-1426

  Tripathy, Rabindranath ^a   McHugh, Robert J ^a   Bacon, Edward R ^a   Salvino, Joseph M ^a   Morton, George C ^a   Aimone, Lisa D ^a   Huang, Zeck ^a   Mathiasen, Joanne R ^a   Dicamillo, Amy ^a   Huffman, Mark J ^a   McKenna, Beth A ^a   Kopec, Karla ^a   Lu, Lily D ^a   Qian, Jie ^a   Angeles, Thelma S ^a   Connors, Thomas ^a   Spais, Chrysanthe ^a   Holskin, Beverly ^a   Duzic, Emir ^a   Schaffhauser, Hervé ^a   Rossé, Gerard C ^a   more..

^a CEPHALON INC   (United States)

Author keywords

5 HT 6 receptor antagonist; Cognition; Cognitive dysfunction; Pharmacophore model; Rat social recognition test

Indexed keywords

7 ARYLSULFONYL 1,2,3,4, 4A,9A HEXAHYDRO BENZO[4,5]FURO[2,3 C]PYRIDINE; 7 BENZENESULFONYL 1,2,3,4 TETRAHYDRO BENZO[4,5]FURO[2,3 C]PYRIDINE; SEROTONIN 6 ANTAGONIST; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG IDENTIFICATION; DRUG METABOLISM; DRUG PENETRATION; DRUG POTENCY; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; LIVER MICROSOME METABOLISM; MOUSE; NONHUMAN; PHARMACOPHORE; PROCESS OPTIMIZATION; RAT; RECOGNITION;

ANIMALS; BRAIN; DOGS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STEREOISOMERISM; SULFONES;

ANIMALIA; CANIS FAMILIARIS; RATTUS;

EID: 84856218005     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.12.026     Document Type: Article

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