Identification of phospholipid species affected by miltefosine action in Leishmania donovani cultures using LC-ELSD, LC-ESI/MS, and multivariate data analysis

Analytical and Bioanalytical Chemistry

Volumn 402, Issue 3, 2012, Pages 1169-1182

  Imbert, L ^a   Ramos, R G ^a,c   Libong, D ^a   Abreu, S ^a   Loiseau, P M ^b   Chaminade, P ^a  

^a University Paris Saclay   (France)

^b UNIVERSITÉ PARIS SUD   (France)

^c UNIVERSITY OF CONCEPCIÓN   (Chile)

Author keywords

Electrospray; Leishmaniasis; Lipidomic; Liquid chromatography; Mass spectrometry; Phospholipids

Indexed keywords

ELECTROSPRAYS; EVAPORATIVE LIGHT SCATTERING DETECTION; LEISHMANIA; LEISHMANIASIS; LIPIDOMIC; MECHANISM OF ACTION; MEMBRANE PHOSPHOLIPIDS; METABOLIC PATHWAYS; MOLECULAR SPECIES; MULTIVARIATE DATA ANALYSIS; NORMAL PHASE; ORAL ROUTE; ORTHOGONAL SIGNALS; STRUCTURAL DETERMINATION; TANDEM MASS SPECTROMETRY;

CHROMATOGRAPHY; CLONING; DISCRIMINANT ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ION SOURCES; LIQUID CHROMATOGRAPHY; LIQUIDS; MASS SPECTROMETRY; METABOLISM; MULTIVARIANT ANALYSIS;

PHOSPHOLIPIDS;

ANTIPROTOZOAL AGENT; DRUG DERIVATIVE; MILTEFOSINE; PHOSPHOLIPID; PHOSPHORYLCHOLINE;

ARTICLE; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; LEISHMANIA DONOVANI; METABOLISM; METHODOLOGY; VISCERAL LEISHMANIASIS;

ANTIPROTOZOAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; LEISHMANIA DONOVANI; LEISHMANIASIS, VISCERAL; PHOSPHOLIPIDS; PHOSPHORYLCHOLINE; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

LEISHMANIA DONOVANI;

EID: 84856213382     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-011-5520-3     Document Type: Article

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