메뉴 건너뛰기




Volumn 59, Issue 1, 2012, Pages 1-8

The new antidiabetic agents in the firing line.... safety reasons or witch hunt?;Los nuevos antidiabéticos en el punto de mira... ¿razones de seguridad o caza de brujas?

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT;

EID: 84856211124     PISSN: 15750922     EISSN: 15792021     Source Type: Journal    
DOI: 10.1016/j.endonu.2011.11.002     Document Type: Article
Times cited : (5)

References (56)
  • 1
    • 84856231888 scopus 로고    scopus 로고
    • US Food and Drug Administration. FDA significantly restricts access to the diabetes drug Avandia. Disponible en: (consultado 27 Sep).
    • US Food and Drug Administration. FDA significantly restricts access to the diabetes drug Avandia. Disponible en: (consultado 27 Sep 2010). http://www.fda.gov/newsevents/newsroom/pressannouncements/UCM226975htm.
    • (2010)
  • 2
    • 62949147825 scopus 로고    scopus 로고
    • European Medicines Agency
    • European Medicines Agency recommends suspension of Avandia, Avandamet, Avaglim. Disponible en: (consultado 27 Sep 2010).
    • European Medicines Agency. European Medicines Agency recommends suspension of Avandia, Avandamet, Avaglim. Disponible en: (consultado 27 Sep 2010). http://www.ema.europa.eu/ema/index.jsp%3Fcurl=pages/news_and_events/news/2010/09/news_detail_001119.jsp%26murl=menus/news_and_events/news_and_events.jsp%26miid=WC0b01ac058004d5cl%26jsenabled=true.
    • (2010)
  • 3
    • 34250212715 scopus 로고    scopus 로고
    • Effect of rosiglitazona on the risk of myocardial infarction and death from cardiovascular causes
    • Nissen S.E., Wolski K. Effect of rosiglitazona on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 2007, 356:2457-2471.
    • (2007) N Engl J Med , vol.356 , pp. 2457-2471
    • Nissen, S.E.1    Wolski, K.2
  • 4
    • 0003527862 scopus 로고    scopus 로고
    • World Health Organization.
    • Diabetes Fact Sheet. Disponible en: (Consultado 29 Dic 2009).
    • World Health Organization. Diabetes Fact Sheet. Disponible en: (Consultado 29 Dic 2009). http://www.who.int/mediacentre/factsheets/fs312/en/index.html.
  • 5
    • 84856211189 scopus 로고    scopus 로고
    • US Food and Drug Administration. Guidance for Industry.
    • Diabetes Mellitus-Evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes. [consultado 26/4]. Disponible en:
    • US Food and Drug Administration. Guidance for Industry. Diabetes Mellitus-Evaluating cardiovascular risk in new antidiabetic therapies to treat type 2 diabetes. [consultado 26/4/2010]. Disponible en: http://www.fda.gov/downloads/Drugs/Guidance%20ComplianceRegulatoryInformation/Guidances/ucm071627.pdf.
    • (2010)
  • 6
    • 78649681316 scopus 로고    scopus 로고
    • The Avandia debate: An unhappy conclusion
    • Bloomgarden Z. The Avandia debate: An unhappy conclusion. J Diab 2010, 2:221-222.
    • (2010) J Diab , vol.2 , pp. 221-222
    • Bloomgarden, Z.1
  • 7
    • 26244453309 scopus 로고    scopus 로고
    • Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomized controlled trial
    • Dormandy J., Charbonnel B., Eckland D., Erdmann E., Massi-Benedetti M., Moules I.K., et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macroVascular Events): a randomized controlled trial. Lancet 2005, 366:1279-1289.
    • (2005) Lancet , vol.366 , pp. 1279-1289
    • Dormandy, J.1    Charbonnel, B.2    Eckland, D.3    Erdmann, E.4    Massi-Benedetti, M.5    Moules, I.K.6
  • 8
    • 70449467324 scopus 로고    scopus 로고
    • CHICAGO, PERISCOPE and PROactive: CV risk modification in diabetes with pioglitazone
    • Betteridge J. CHICAGO, PERISCOPE and PROactive: CV risk modification in diabetes with pioglitazone. Fund Clin Pharmacol 2009, 23:675-679.
    • (2009) Fund Clin Pharmacol , vol.23 , pp. 675-679
    • Betteridge, J.1
  • 9
    • 34250773317 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma agonists inhibit the proliferation and invasion of human colon cancer cells
    • Shen D., Deng C., Zhang M. Peroxisome proliferator-activated receptor gamma agonists inhibit the proliferation and invasion of human colon cancer cells. Postgrad Med J 2007, 83:414-419.
    • (2007) Postgrad Med J , vol.83 , pp. 414-419
    • Shen, D.1    Deng, C.2    Zhang, M.3
  • 11
    • 84856223991 scopus 로고    scopus 로고
    • Takeda Pharmaceuticals America, Inc.
    • Actos (Pioglitazone Hydrochloride) Tablets: Full Prescribing Information. Disponible en: (Consultado 26 Aug 2010).
    • Takeda Pharmaceuticals America, Inc. Actos (Pioglitazone Hydrochloride) Tablets: Full Prescribing Information. 2009; Disponible en: (Consultado 26 Aug 2010). http://www.actos.com/actospro/home.aspx.
    • (2009)
  • 12
    • 33845789088 scopus 로고    scopus 로고
    • Urothelial carcinogenesis in the urinary bladder of male rats treated with muraglitazar, a PPAR alpha/gamma agonist: evidence for urolithiasis as the inciting event in the mode of action
    • Dominick M.A., White M.R., Sanderson T.P., Van Vleet T., Cohen S.M., Arnold L.E., et al. Urothelial carcinogenesis in the urinary bladder of male rats treated with muraglitazar, a PPAR alpha/gamma agonist: evidence for urolithiasis as the inciting event in the mode of action. Toxicol Pathol 2006, 34:903-910.
    • (2006) Toxicol Pathol , vol.34 , pp. 903-910
    • Dominick, M.A.1    White, M.R.2    Sanderson, T.P.3    Van Vleet, T.4    Cohen, S.M.5    Arnold, L.E.6
  • 13
    • 34249747832 scopus 로고    scopus 로고
    • Cancer risks in thiazolidinedione users compared to other anti-diabetic agets
    • Koro C., Barrett S., Qizilbash N. Cancer risks in thiazolidinedione users compared to other anti-diabetic agets. Pharmacoepidemiol drug Saf 2007, 16:485-492.
    • (2007) Pharmacoepidemiol drug Saf , vol.16 , pp. 485-492
    • Koro, C.1    Barrett, S.2    Qizilbash, N.3
  • 14
    • 34248192254 scopus 로고    scopus 로고
    • Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes
    • Govindajaran R., Ratnasinghe L., Simmons D.L. Thiazolidinediones and the risk of lung, prostate, and colon cancer in patients with diabetes. J Clin Oncol 2007, 12:1476-1481.
    • (2007) J Clin Oncol , vol.12 , pp. 1476-1481
    • Govindajaran, R.1    Ratnasinghe, L.2    Simmons, D.L.3
  • 16
    • 84856215139 scopus 로고    scopus 로고
    • Risque de cancer de la vessie chez les personnes diabétiques traitées par pioglitazone en France: une étude de cohorte sur les données du SNIIRAM et du PMSI. [consultado 7/6]. Disponible en:
    • Risque de cancer de la vessie chez les personnes diabétiques traitées par pioglitazone en France: une étude de cohorte sur les données du SNIIRAM et du PMSI. [consultado 7/6/2011]. Disponible en: http://www.afssaps.fr/var/afssaps_site/storage/original/application/b42a6bf9a1b63c3dbec7388d3914687b.pdf.
    • (2011)
  • 17
    • 80051975559 scopus 로고    scopus 로고
    • Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting
    • Piccinni C., Motola D., Marchesini G., Poluzzi E. Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting. Diabetes Care 2011, 34:1369-1371.
    • (2011) Diabetes Care , vol.34 , pp. 1369-1371
    • Piccinni, C.1    Motola, D.2    Marchesini, G.3    Poluzzi, E.4
  • 18
    • 2542465496 scopus 로고    scopus 로고
    • US Food and Drug Administration.
    • Actos (pioglitazone): ongoing safety review. Potential increased risk of bladder cancer. Disponible en: (consultado15 Jun).
    • US Food and Drug Administration. Actos (pioglitazone): ongoing safety review. Potential increased risk of bladder cancer. Disponible en: (consultado15 Jun 2011). http://www.fda.gov/Drugs/DrugSafety/UCM259150.htm.
    • (2011)
  • 19
    • 84856215137 scopus 로고    scopus 로고
    • Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). Pioglitazona: evaluación europea de su posible asociación con el cáncer de vejiga. [consultado 28/6]. Disponible en:
    • Agencia Española de Medicamentos y Productos Sanitarios (AEMPS). Pioglitazona: evaluación europea de su posible asociación con el cáncer de vejiga. [consultado 28/6/2011]. Disponible en: http://www.aemps.gob.es/informa/notasInformativas/medicamentosUsoHumano/seguridad/2011/NI-MUH_10-2011.htm.
    • (2011)
  • 20
    • 80052189619 scopus 로고    scopus 로고
    • Diabetes field cautiously upbeat despite possible setback for leading SGLT2 inhibitor
    • Jones D. Diabetes field cautiously upbeat despite possible setback for leading SGLT2 inhibitor. Nat Rev Drug Discov 2011, 10:645-646.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 645-646
    • Jones, D.1
  • 21
    • 84856231887 scopus 로고    scopus 로고
    • Victoza® (Package insert). Princeton, NJ: Novo Nordisk, Inc; 2010. Disponiible en: (consultado 19 Mar).
    • Victoza® (Package insert). Princeton, NJ: Novo Nordisk, Inc; 2010. Disponiible en: (consultado 19 Mar 2010). http://www.accessdata.fda.gov/drugsatfda_docs/label/2010/0223411bl.pdf.
    • (2010)
  • 22
    • 74549177233 scopus 로고    scopus 로고
    • A review of efficacy and safety data regarding the use of liraglutide, a once-daily human glucagon-like peptide 1 analogue, in the treatment of type 2 diabetes mellitus
    • Montanya E., Sesti G. A review of efficacy and safety data regarding the use of liraglutide, a once-daily human glucagon-like peptide 1 analogue, in the treatment of type 2 diabetes mellitus. Clin Ther 2009, 31:2472-2488.
    • (2009) Clin Ther , vol.31 , pp. 2472-2488
    • Montanya, E.1    Sesti, G.2
  • 23
    • 84875226471 scopus 로고    scopus 로고
    • Liraglutide for the treatment of type 2 diabetes: a clinical update
    • [Epub ahead of print]
    • Peters K. Liraglutide for the treatment of type 2 diabetes: a clinical update. Am J Ther 2011, [Epub ahead of print].
    • (2011) Am J Ther
    • Peters, K.1
  • 24
    • 77956932248 scopus 로고    scopus 로고
    • Early clinical studies with liraglutide
    • Schmidt W.E. Early clinical studies with liraglutide. Int J Clin Pract 2010, 64:12-20.
    • (2010) Int J Clin Pract , vol.64 , pp. 12-20
    • Schmidt, W.E.1
  • 26
    • 77950228684 scopus 로고    scopus 로고
    • Glucagon-like-peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    • Bjerre Knudsen L., Madsen L.W., Andersen S., Almholt K., De Boer A.S., Drucker D.J., et al. Glucagon-like-peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology 2010, 151:1473-1486.
    • (2010) Endocrinology , vol.151 , pp. 1473-1486
    • Bjerre Knudsen, L.1    Madsen, L.W.2    Andersen, S.3    Almholt, K.4    De Boer, A.S.5    Drucker, D.J.6
  • 27
    • 38549146030 scopus 로고    scopus 로고
    • The murine glucagon-like-peptide-1 receptor is essential for control of bone resorption
    • Yamada C., Yamada Y., Tsukiyama K. The murine glucagon-like-peptide-1 receptor is essential for control of bone resorption. Endocrinology 2008, 149:574-579.
    • (2008) Endocrinology , vol.149 , pp. 574-579
    • Yamada, C.1    Yamada, Y.2    Tsukiyama, K.3
  • 28
    • 78649661323 scopus 로고    scopus 로고
    • Liraglutide and calcitonin
    • Bloomgarden Z. Liraglutide and calcitonin. J Diab 2010, 2:223-224.
    • (2010) J Diab , vol.2 , pp. 223-224
    • Bloomgarden, Z.1
  • 30
    • 79952284556 scopus 로고    scopus 로고
    • GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5,000 subjects with type 2 diabetes or nondiabetic obese subjects treated with human GLP-1 analog, liraglutide
    • Hegedüs L., Moses A.C., Zdravkovic M., Thi T.L., Daniels G.H. GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5,000 subjects with type 2 diabetes or nondiabetic obese subjects treated with human GLP-1 analog, liraglutide. J Clin Endocrinol Metab 2011, 853-860.
    • (2011) J Clin Endocrinol Metab , pp. 853-860
    • Hegedüs, L.1    Moses, A.C.2    Zdravkovic, M.3    Thi, T.L.4    Daniels, G.H.5
  • 31
    • 77649294607 scopus 로고    scopus 로고
    • Weighing risks and benefits of liraglutide, The FDA's review of a new antidiabetic therapy
    • Parks M., Rosebraugh C. Weighing risks and benefits of liraglutide, The FDA's review of a new antidiabetic therapy. N Engl J Med 2010, 362:774-775.
    • (2010) N Engl J Med , vol.362 , pp. 774-775
    • Parks, M.1    Rosebraugh, C.2
  • 32
    • 79954538769 scopus 로고    scopus 로고
    • Do we have enough data to confirm the link between antidiabetic drug use and cancer development?
    • Drzewoski J., Drozdowska A., Sliwinska A. Do we have enough data to confirm the link between antidiabetic drug use and cancer development?. Pol Arch Med Wewn 2011, 121:81-87.
    • (2011) Pol Arch Med Wewn , vol.121 , pp. 81-87
    • Drzewoski, J.1    Drozdowska, A.2    Sliwinska, A.3
  • 33
    • 77955511122 scopus 로고    scopus 로고
    • Cancer and diabetes: are we ready for prime time?
    • Smith U., Gale E.M. Cancer and diabetes: are we ready for prime time?. Diabetologia 2010, 53:1541-1544.
    • (2010) Diabetologia , vol.53 , pp. 1541-1544
    • Smith, U.1    Gale, E.M.2
  • 34
    • 79953776342 scopus 로고    scopus 로고
    • Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials
    • Johnson J.A., Bowker S.L. Intensive glycaemic control and cancer risk in type 2 diabetes: a meta-analysis of major trials. Diabetologia 2011, 54:25-31.
    • (2011) Diabetologia , vol.54 , pp. 25-31
    • Johnson, J.A.1    Bowker, S.L.2
  • 35
    • 78649302320 scopus 로고    scopus 로고
    • Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis
    • Decensi A., Puntoni M., Goodwin P. Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res (Phila) 2010, 3:1451-1461.
    • (2010) Cancer Prev Res (Phila) , vol.3 , pp. 1451-1461
    • Decensi, A.1    Puntoni, M.2    Goodwin, P.3
  • 36
    • 75149179169 scopus 로고    scopus 로고
    • Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16
    • Landman G.W., Kleefstra N., van Hateren K.J.J. Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16. Diabetes Care 2010, 33:322-326.
    • (2010) Diabetes Care , vol.33 , pp. 322-326
    • Landman, G.W.1    Kleefstra, N.2    van Hateren, K.J.J.3
  • 37
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker S.L., Majumdar S.R., Veugelers P., Johnson J.A. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 2006, 29:254-258.
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 38
    • 34948847587 scopus 로고    scopus 로고
    • Are sulphonylureas all the same? A cohort study on cardiovascular and cancer-related mortality
    • Monami M., Balzi D., Lamanna C. Are sulphonylureas all the same? A cohort study on cardiovascular and cancer-related mortality. Diabetes Metab Res Rev 2007, 23:479-484.
    • (2007) Diabetes Metab Res Rev , vol.23 , pp. 479-484
    • Monami, M.1    Balzi, D.2    Lamanna, C.3
  • 39
    • 50649112783 scopus 로고    scopus 로고
    • Drug-induced pancreatitis
    • Balani A.R., Grendell J.H. Drug-induced pancreatitis. Drug Saf 2008, 31:823-837.
    • (2008) Drug Saf , vol.31 , pp. 823-837
    • Balani, A.R.1    Grendell, J.H.2
  • 40
    • 65949111736 scopus 로고    scopus 로고
    • Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes
    • Noel R.A., Braun D.K., Patterson R.E., Bloomgren G.L. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes. Diabetes Care 2009, 32:834-838.
    • (2009) Diabetes Care , vol.32 , pp. 834-838
    • Noel, R.A.1    Braun, D.K.2    Patterson, R.E.3    Bloomgren, G.L.4
  • 41
    • 77954671985 scopus 로고    scopus 로고
    • Do incretin-based therapies cause acute pancreatitis?
    • Olansky L. Do incretin-based therapies cause acute pancreatitis?. J Diabetes Sci Technol 2010, 4:228-229.
    • (2010) J Diabetes Sci Technol , vol.4 , pp. 228-229
    • Olansky, L.1
  • 42
    • 33646354927 scopus 로고    scopus 로고
    • Exenatide (exendin-4)-induced pancreatitis: a case report
    • Denker P.S., Dimarco P.E. Exenatide (exendin-4)-induced pancreatitis: a case report. Diabetes Care 2006, 29:471.
    • (2006) Diabetes Care , vol.29 , pp. 471
    • Denker, P.S.1    Dimarco, P.E.2
  • 44
    • 79951704452 scopus 로고    scopus 로고
    • Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis
    • Garg R., Chen W., Pendergrass M. Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis. Diabetes Care 2010 Nov, 33:2349-2354.
    • (2010) Diabetes Care , vol.33 , pp. 2349-2354
    • Garg, R.1    Chen, W.2    Pendergrass, M.3
  • 45
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M., Matveyenko A.V., Gier B., Elashoff R., Butler P.C. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology 2011, 141:150-156.
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3    Elashoff, R.4    Butler, P.C.5
  • 46
    • 84855488680 scopus 로고    scopus 로고
    • ®)
    • Arzneimittelkommission der Deutschen ärzrteschaft (Drug Commission of the German Medical Association)
    • ®). Dtsch Arztebl 2011, 108:A-1080. Arzneimittelkommission der Deutschen ärzrteschaft (Drug Commission of the German Medical Association).
    • (2011) Dtsch Arztebl , vol.108
  • 48
    • 72449148137 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire?
    • Butler P.C., Matveyenko A.V., Dry S., Bhushan A., Elashoff R. Glucagon-like peptide-1 therapy and the exocrine pancreas: innocent bystander or friendly fire?. Diabetologia 2010, 53:1-6.
    • (2010) Diabetologia , vol.53 , pp. 1-6
    • Butler, P.C.1    Matveyenko, A.V.2    Dry, S.3    Bhushan, A.4    Elashoff, R.5
  • 50
    • 67650245531 scopus 로고    scopus 로고
    • Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin
    • Matveyenko A.V., Dry S., Cox H.I., Moshtaghian A., Gurlo T., Galasso R., et al. Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin. Diabetes 2009, 58:1604-1615.
    • (2009) Diabetes , vol.58 , pp. 1604-1615
    • Matveyenko, A.V.1    Dry, S.2    Cox, H.I.3    Moshtaghian, A.4    Gurlo, T.5    Galasso, R.6
  • 51
    • 77953192546 scopus 로고    scopus 로고
    • An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of Phase II and III clinical trials
    • Ligueros-Saylan M., Foley J.E., Schweizer A., Couturier A., Kothny W. An assessment of adverse effects of vildagliptin versus comparators on the liver, the pancreas, the immune system, the skin and in patients with impaired renal function from a large pooled database of Phase II and III clinical trials. Diabetes Obes Metab 2010, 12:495-509.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 495-509
    • Ligueros-Saylan, M.1    Foley, J.E.2    Schweizer, A.3    Couturier, A.4    Kothny, W.5
  • 52
    • 79959678186 scopus 로고    scopus 로고
    • Vildagliptin-induced acute pancreatitis
    • Girgis C.M., Champion B.L. Vildagliptin-induced acute pancreatitis. Endocr Pract 2011, 17:e48-e50.
    • (2011) Endocr Pract , vol.17
    • Girgis, C.M.1    Champion, B.L.2
  • 53
    • 79951701438 scopus 로고    scopus 로고
    • Use of dipeptidyl peptidase-4 inhibitors and the reporting of infections: a disproportionality analysis in the World Health Organization VigiBase
    • Willemen M.J., Mantel-Teeuwisse A.K., Straus S.M., Meyboom R.H., Egberts T.C., Leufkens H.G. Use of dipeptidyl peptidase-4 inhibitors and the reporting of infections: a disproportionality analysis in the World Health Organization VigiBase. Diabetes Care 2011, 34:369-374.
    • (2011) Diabetes Care , vol.34 , pp. 369-374
    • Willemen, M.J.1    Mantel-Teeuwisse, A.K.2    Straus, S.M.3    Meyboom, R.H.4    Egberts, T.C.5    Leufkens, H.G.6
  • 55
    • 77951069227 scopus 로고    scopus 로고
    • Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,246 patients with type 2 diabetes
    • Williams-Herman D., Engel S.S., Round E. Safety and tolerability of sitagliptin in clinical studies: a pooled analysis of data from 10,246 patients with type 2 diabetes. BMC Endocr Disord 2010, 10:7.
    • (2010) BMC Endocr Disord , vol.10 , pp. 7
    • Williams-Herman, D.1    Engel, S.S.2    Round, E.3
  • 56
    • 84856228450 scopus 로고    scopus 로고
    • Us Food and Drug Administration. Running Clinical Trials. [consultado 5/4/2011]. Disponible en:
    • Us Food and Drug Administration. Running Clinical Trials. [consultado 5/4/2011]. Disponible en:. http://www.fda.gov/ScienceResearch/SpecialTopics/RunningClinicalTrials/default.htm.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.