Reply to Colin Anderson's commentary on "ten experiments that would make a difference in understanding immune mechanisms"

Cellular and Molecular Life Sciences

Volumn 69, Issue 3, 2012, Pages 417-422

  Cohn, Melvin ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; EPITOPE; T LYMPHOCYTE RECEPTOR;

ALLOIMMUNITY; ANTIGEN PRESENTING CELL; ANTIGEN RECOGNITION; B LYMPHOCYTE; CELL INTERACTION; DENDRITIC CELL; GENE FREQUENCY; GENETIC POLYMORPHISM; HAPLOTYPE; IMMUNE RESPONSE; IMMUNOCOMPETENCE; IMMUNOLOGY; NONHUMAN; NOTE; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STABILITY; REGULATORY T LYMPHOCYTE; SEMANTICS; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMUS;

EID: 84856210693     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0890-4     Document Type: Note

References (18)

1. M Cohn 2011 On the logic of restrictive recognition of peptide by the T-cell antigen receptor Immunol Res 50 49 68 20931295 10.1007/s12026-010-8173-y 1:CAS:528:DC%2BC3MXlsVOht74%3D
2. M Cohn 2008 The Tritope model for restrictive recognition of antigen by T-cells: II. Implications for ontogeny, evolution and physiology Mol Immunol 45 632 652 17889366 10.1016/j.molimm.2006.02.033 1:CAS:528:DC%2BD2sXhtFalsLnJ (Pubitemid 47498585)
3. M Cohn 2005 The Tritope model for restrictive recognition of antigen by T-cells: I. What assumptions about structure are needed to explain function? Mol Immunol 42 1419 1443 15950737 10.1016/j.molimm.2005.01.013 1:CAS:528: DC%2BD2MXkvFWjsrg%3D (Pubitemid 40798930)
4. RE Langman M Cohn 1999 The standard model of T-cell receptor function: a critical reassessment Scand J Immunol 49 570 577 10354368 10.1046/j.1365-3083. 1999.00569.x 1:CAS:528:DyaK1MXktFylu7k%3D (Pubitemid 29292518)
5. GP Morris PP Ni PM Allen 2011 Alloreactivity is limited by the endogenous peptide repertoire PNAS 108 9 3695 3700 21321209 10.1073/pnas.1017015108 1:CAS:528:DC%2BC3MXivFOht7o%3D
6. Cohn M, Langman RE, Mata J (2002) A computerized model for the self-nonself discrimination at the level of the T-helper (Th-genesis). I. The origin of "primer" effector T-helpers. Int'l Immunol 14:1105-1112 (Pubitemid 35175218)
7. Langman RE, Mata JJ, Cohn M (2003) A computerized model for the self-nonself discrimination at the level of the T-helper (Th genesis) II. The behavior of the system upon encounter with nonself antigens. Int Immun 15 (5):593-609 (Pubitemid 36519397)
8. M Cohn 2005 A biological context for the self-nonself discrimination and the regulation of effector class by the immune system Immunol Res 31 2 133 150 15778511 10.1385/IR:31:2:133 1:CAS:528:DC%2BD2MXkvVWlsb4%3D (Pubitemid 40631384)
9. M Cohn 2005 The common sense of the self-nonself discrimination Springer Semin Immunopathol 27 1 3 17 15711952 10.1007/s00281-005-0199-1 (Pubitemid 40905059)
10. M Cohn 2004 Whither T-suppressors: If they didn't exist would we have to invent them? Cell Immunol 227 81 92 15135290 10.1016/j.cellimm.2004.02.004 1:CAS:528:DC%2BD2cXjsl2gsLo%3D (Pubitemid 38595380)
11. M Cohn 2008 What roles do regulatory T-cells play in the control of the adaptive immune response? Int Immunol 20 9 1107 1118 18658168 10.1093/intimm/dxn088 1:CAS:528:DC%2BD1cXht1SrsrzM
12. M Cohn 2009 On the opposing views of the self-nonself discrimination by the immune system Immunol Cell Biol 87 113 119 19048020 10.1038/icb.2008.96 1:CAS:528:DC%2BD1MXit1ahtb4%3D
13. M Cohn 2009 The discussion with Jacques Miller: illustrating the limitations of pure empiricism Immunol Cell Biol 87 435 437 19434068 10.1038/icb.2009.34
14. Brent L (1997) A history of transplantation immunology. Academic Press, San Diego
15. CC Anderson JM Carroll S Gallucci JP Ridge AW Scheever P Matzinger 2001 Testing time-, ignorance-, danger-based models of tolerance J Immunol 166 3663 3671 11238605 1:CAS:528:DC%2BD3MXitVGntLs%3D (Pubitemid 32224887)
16. CC Anderson 2009 Placing regulatory T cells into global theories of immunity: an analysis of Cohn's challenge to integrity (Dembic) Scand J Immunol 70 321 325 19751266 10.1111/j.1365-3083.2009.02288.x 1:CAS:528: DC%2BD1MXht1OhsLbF
17. RE Langman M Cohn 1996 A short history of time and space in immune discrimination Scand J Immunol 44 544 548 8972733 10.1046/j.1365-3083.1996.d01- 359.x 1:CAS:528:DyaK2sXisVWksA%3D%3D (Pubitemid 26400365)
18. RE Langman M Cohn 1997 A short history of time and space in immune discrimination: reply to the commentaries Scand J Immunol 46 113 116 9583990 10.1046/j.1365-3083.1997.d01-110.x 1:STN:280:DyaK1c3ks1GjtQ%3D%3D