메뉴 건너뛰기




Volumn 227, Issue 5, 2012, Pages 2138-2144

Src family kinases regulate renal epithelial dedifferentiation through activation of EGFR/PI3K signaling

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; CYTOKERATIN 18; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; UO 126; VIMENTIN;

EID: 84856179605     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22946     Document Type: Article
Times cited : (25)

References (44)
  • 1
    • 0020587101 scopus 로고
    • Differentiation of cell types in the mammalian kidney by immunofluorescence microscopy using antibodies to intermediate filament proteins and desmoplakins
    • Bachmann S, Kriz W, Kuhn C, Franke WW. 1983. Differentiation of cell types in the mammalian kidney by immunofluorescence microscopy using antibodies to intermediate filament proteins and desmoplakins. Histochemistry 77: 365-394.
    • (1983) Histochemistry , vol.77 , pp. 365-394
    • Bachmann, S.1    Kriz, W.2    Kuhn, C.3    Franke, W.W.4
  • 2
    • 33845884030 scopus 로고    scopus 로고
    • Differentiation status of human renal proximal and distal tubular epithelial cells in vitro: Differential expression of characteristic markers
    • Baer PC, Bereiter-Hahn J, Schubert R, Geiger H. 2006. Differentiation status of human renal proximal and distal tubular epithelial cells in vitro: Differential expression of characteristic markers. Cells, Tissues, Organs 184: 16-22.
    • (2006) Cells, Tissues, Organs , vol.184 , pp. 16-22
    • Baer, P.C.1    Bereiter-Hahn, J.2    Schubert, R.3    Geiger, H.4
  • 3
    • 0029841299 scopus 로고    scopus 로고
    • TGF beta 1 promotes actin cytoskeleton reorganization and migratory phenotype in epithelial tracheal cells in primary culture
    • Boland S, Boisvieux-Ulrich E, Houcine O, Baeza-Squiban A, Pouchelet M, Schoevaert D, Marano F. 1996. TGF beta 1 promotes actin cytoskeleton reorganization and migratory phenotype in epithelial tracheal cells in primary culture. J Cell Sci 109: 2207-2219.
    • (1996) J Cell Sci , vol.109 , pp. 2207-2219
    • Boland, S.1    Boisvieux-Ulrich, E.2    Houcine, O.3    Baeza-Squiban, A.4    Pouchelet, M.5    Schoevaert, D.6    Marano, F.7
  • 4
    • 0037836057 scopus 로고    scopus 로고
    • Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure
    • Bonventre JV. 2003a. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 14: S55-S61.
    • (2003) J Am Soc Nephrol , vol.14
    • Bonventre, J.V.1
  • 5
    • 0037836057 scopus 로고    scopus 로고
    • Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure
    • Bonventre JV. 2003b. Dedifferentiation and proliferation of surviving epithelial cells in acute renal failure. J Am Soc Nephrol 14: S55-S61.
    • (2003) J Am Soc Nephrol , vol.14
    • Bonventre, J.V.1
  • 6
    • 58149361842 scopus 로고    scopus 로고
    • Signaling in regulation of podocyte phenotypes
    • Chuang PY, He JC. 2009. Signaling in regulation of podocyte phenotypes. Nephron Physiol 111: 9-15.
    • (2009) Nephron Physiol , vol.111 , pp. 9-15
    • Chuang, P.Y.1    He, J.C.2
  • 7
    • 22144440464 scopus 로고    scopus 로고
    • Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells
    • Duffield JS, Park KM, Hsiao LL, Kelley VR, Scadden DT, Ichimura T, Bonventre JV. 2005. Restoration of tubular epithelial cells during repair of the postischemic kidney occurs independently of bone marrow-derived stem cells. J Clin Invest 115: 1743-1755.
    • (2005) J Clin Invest , vol.115 , pp. 1743-1755
    • Duffield, J.S.1    Park, K.M.2    Hsiao, L.L.3    Kelley, V.R.4    Scadden, D.T.5    Ichimura, T.6    Bonventre, J.V.7
  • 8
    • 38349063412 scopus 로고    scopus 로고
    • Plasticity of epithelial cells derived from human normal and ADPKD kidneys in primary cultures
    • Elberg G, Guruswamy S, Logan CJ, Chen L, Turman MA. 2008. Plasticity of epithelial cells derived from human normal and ADPKD kidneys in primary cultures. Cell Tissue Res 331: 495-508.
    • (2008) Cell Tissue Res , vol.331 , pp. 495-508
    • Elberg, G.1    Guruswamy, S.2    Logan, C.J.3    Chen, L.4    Turman, M.A.5
  • 9
    • 2942569101 scopus 로고    scopus 로고
    • Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor
    • Fischer OM, Hart S, Gschwind A, Prenzel N, Ullrich A. 2004. Oxidative and osmotic stress signaling in tumor cells is mediated by ADAM proteases and heparin-binding epidermal growth factor. Mol Cell Biol 24: 5172-5183.
    • (2004) Mol Cell Biol , vol.24 , pp. 5172-5183
    • Fischer, O.M.1    Hart, S.2    Gschwind, A.3    Prenzel, N.4    Ullrich, A.5
  • 11
    • 0018733376 scopus 로고
    • Widespread occurrence of intermediate-sized filaments of the vimentin-type in cultured cells from diverse vertebrates
    • Franke WW, Schmid E, Winter S, Osborn M, Weber K. 1979. Widespread occurrence of intermediate-sized filaments of the vimentin-type in cultured cells from diverse vertebrates. Exp Cell Res 123: 25-46.
    • (1979) Exp Cell Res , vol.123 , pp. 25-46
    • Franke, W.W.1    Schmid, E.2    Winter, S.3    Osborn, M.4    Weber, K.5
  • 12
    • 41549164754 scopus 로고    scopus 로고
    • Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cells
    • Fujita-Yoshigaki J, Matsuki-Fukushima M, Sugiya H. 2008. Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cells. Am J Physiol Cell Physiol 294: C774-C785.
    • (2008) Am J Physiol Cell Physiol , vol.294
    • Fujita-Yoshigaki, J.1    Matsuki-Fukushima, M.2    Sugiya, H.3
  • 13
    • 67650999336 scopus 로고    scopus 로고
    • Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis
    • Godoy P, Hengstler JG, Ilkavets I, Meyer C, Bachmann A, Muller A, Tuschl G, Mueller SO, Dooley S. 2009. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology 49: 2031-2043.
    • (2009) Hepatology , vol.49 , pp. 2031-2043
    • Godoy, P.1    Hengstler, J.G.2    Ilkavets, I.3    Meyer, C.4    Bachmann, A.5    Muller, A.6    Tuschl, G.7    Mueller, S.O.8    Dooley, S.9
  • 14
    • 0024528136 scopus 로고
    • Enhancement of gentamicin-induced nephrotoxicity by Mg deficiency in non-pregnant rats. Morphological, enzyme histochemical and immunohistochemical studies
    • Gossrau R, Gunther T, Graf R. 1989. Enhancement of gentamicin-induced nephrotoxicity by Mg deficiency in non-pregnant rats. Morphological, enzyme histochemical and immunohistochemical studies. Histochemistry 90: 489-496.
    • (1989) Histochemistry , vol.90 , pp. 489-496
    • Gossrau, R.1    Gunther, T.2    Graf, R.3
  • 15
    • 0023618920 scopus 로고
    • Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney
    • Grone HJ, Weber K, Grone E, Helmchen U, Osborn M. 1987. Coexpression of keratin and vimentin in damaged and regenerating tubular epithelia of the kidney. Am J Pathol 129: 1-8.
    • (1987) Am J Pathol , vol.129 , pp. 1-8
    • Grone, H.J.1    Weber, K.2    Grone, E.3    Helmchen, U.4    Osborn, M.5
  • 16
    • 42449141549 scopus 로고    scopus 로고
    • Regulation of dedifferentiation and redifferentiation in renal proximal tubular cells by the epidermal growth factor receptor
    • Hallman MA, Zhuang S, Schnellmann RG. 2008. Regulation of dedifferentiation and redifferentiation in renal proximal tubular cells by the epidermal growth factor receptor. J Pharmacol Exp Ther 325: 520-528.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 520-528
    • Hallman, M.A.1    Zhuang, S.2    Schnellmann, R.G.3
  • 18
    • 0024238913 scopus 로고
    • Alterations in intermediate filament proteins in rat kidney proximal tubule epithelial cells
    • Hatzinger PB, Chen Q, Dong LQ, Stevens JL. 1988. Alterations in intermediate filament proteins in rat kidney proximal tubule epithelial cells. Biochem Biophys Res Commun 157: 1316-1322.
    • (1988) Biochem Biophys Res Commun , vol.157 , pp. 1316-1322
    • Hatzinger, P.B.1    Chen, Q.2    Dong, L.Q.3    Stevens, J.L.4
  • 19
    • 4944222787 scopus 로고    scopus 로고
    • Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways
    • He JC, Husain M, Sunamoto M, D'Agati VD, Klotman ME, Iyengar R, Klotman PE. 2004. Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1, 2 pathways. J Clin Invest 114: 643-651.
    • (2004) J Clin Invest , vol.114 , pp. 643-651
    • He, J.C.1    Husain, M.2    Sunamoto, M.3    D'Agati, V.D.4    Klotman, M.E.5    Iyengar, R.6    Klotman, P.E.7
  • 20
    • 0021355642 scopus 로고
    • Expression of vimentin and cytokeratin types of intermediate filament proteins in developing and adult human kidneys
    • Holthofer H, Miettinen A, Lehto VP, Lehtonen E, Virtanen I. 1984. Expression of vimentin and cytokeratin types of intermediate filament proteins in developing and adult human kidneys. Lab Invest 50: 552-559.
    • (1984) Lab Invest , vol.50 , pp. 552-559
    • Holthofer, H.1    Miettinen, A.2    Lehto, V.P.3    Lehtonen, E.4    Virtanen, I.5
  • 21
    • 40949152762 scopus 로고    scopus 로고
    • Transactivation of epidermal growth factor receptor in vascular and renal systems in rats with experimental hyperleptinemia: Role in leptin-induced hypertension
    • Jamroz-Wisniewska A, Wojcicka G, Lowicka E, Ksiazek M, Beltowski J. 2008. Transactivation of epidermal growth factor receptor in vascular and renal systems in rats with experimental hyperleptinemia: Role in leptin-induced hypertension. Biochem Pharmacol 75: 1623-1638.
    • (2008) Biochem Pharmacol , vol.75 , pp. 1623-1638
    • Jamroz-Wisniewska, A.1    Wojcicka, G.2    Lowicka, E.3    Ksiazek, M.4    Beltowski, J.5
  • 22
    • 0028981897 scopus 로고
    • Signalling by the p60c-src family of protein-tyrosine kinases
    • Kefalas P, Brown TR, Brickell PM. 1995. Signalling by the p60c-src family of protein-tyrosine kinases. Int J Biochem Cell Biol 27: 551-563.
    • (1995) Int J Biochem Cell Biol , vol.27 , pp. 551-563
    • Kefalas, P.1    Brown, T.R.2    Brickell, P.M.3
  • 24
    • 66049119614 scopus 로고    scopus 로고
    • EGF receptor signaling is involved in expression of osmoprotective TonEBP target gene aldose reductase under hypertonic conditions
    • Kuper C, Steinert D, Fraek ML, Beck FX, Neuhofer W. 2009. EGF receptor signaling is involved in expression of osmoprotective TonEBP target gene aldose reductase under hypertonic conditions. Am J Physiol Renal Physiol 296: F1100-F1108.
    • (2009) Am J Physiol Renal Physiol , vol.296
    • Kuper, C.1    Steinert, D.2    Fraek, M.L.3    Beck, F.X.4    Neuhofer, W.5
  • 25
    • 0345138451 scopus 로고    scopus 로고
    • Functional implication of the interaction between EGF receptor and c-Src
    • Leu TH, Maa MC. 2003. Functional implication of the interaction between EGF receptor and c-Src. Front Biosci 8: s28-s38.
    • (2003) Front Biosci , vol.8
    • Leu, T.H.1    Maa, M.C.2
  • 26
    • 22144474392 scopus 로고    scopus 로고
    • Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney
    • Lin F, Moran A, Igarashi P. 2005. Intrarenal cells, not bone marrow-derived cells, are the major source for regeneration in postischemic kidney. J Clin Invest 115: 1756-1764.
    • (2005) J Clin Invest , vol.115 , pp. 1756-1764
    • Lin, F.1    Moran, A.2    Igarashi, P.3
  • 27
    • 0028276071 scopus 로고
    • Hyperplasia, hypertrophy, and phenotypic alterations in the distal nephron after acute proximal tubular injury in the rat
    • Nouwen EJ, Verstrepen WA, Buyssens N, Zhu MQ, De Broe ME. 1994. Hyperplasia, hypertrophy, and phenotypic alterations in the distal nephron after acute proximal tubular injury in the rat. Lab Invest 70: 479-493.
    • (1994) Lab Invest , vol.70 , pp. 479-493
    • Nouwen, E.J.1    Verstrepen, W.A.2    Buyssens, N.3    Zhu, M.Q.4    De Broe, M.E.5
  • 28
    • 0041382970 scopus 로고    scopus 로고
    • Lack of a functional p21WAF1/CIP1 gene accelerates caspase-independent apoptosis induced by cisplatin in renal cells
    • Nowak G, Price PM, Schnellmann RG. 2003. Lack of a functional p21WAF1/CIP1 gene accelerates caspase-independent apoptosis induced by cisplatin in renal cells. Am J Physiol Renal Physiol 285: F440-F450.
    • (2003) Am J Physiol Renal Physiol , vol.285
    • Nowak, G.1    Price, P.M.2    Schnellmann, R.G.3
  • 32
    • 0033942485 scopus 로고    scopus 로고
    • Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury
    • Terzi F, Burtin M, Hekmati M, Federici P, Grimber G, Briand P, Friedlander G. 2000. Targeted expression of a dominant-negative EGF-R in the kidney reduces tubulo-interstitial lesions after renal injury. J Clin Invest 106: 225-234.
    • (2000) J Clin Invest , vol.106 , pp. 225-234
    • Terzi, F.1    Burtin, M.2    Hekmati, M.3    Federici, P.4    Grimber, G.5    Briand, P.6    Friedlander, G.7
  • 33
    • 0031439247 scopus 로고    scopus 로고
    • Cellular functions regulated by Src family kinases
    • Thomas SM, Brugge JS. 1997. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13: 513-609.
    • (1997) Annu Rev Cell Dev Biol , vol.13 , pp. 513-609
    • Thomas, S.M.1    Brugge, J.S.2
  • 34
    • 0028334132 scopus 로고
    • Renal tissue expression of EGF and EGF receptor after ischaemic tubular injury: An immunohistochemical study
    • Toubeau G, Nonclercq D, Zanen J, Laurent G, Schaudies PR, Heuson-Stiennon JA. 1994. Renal tissue expression of EGF and EGF receptor after ischaemic tubular injury: An immunohistochemical study. Exp Nephrol 2: 229-239.
    • (1994) Exp Nephrol , vol.2 , pp. 229-239
    • Toubeau, G.1    Nonclercq, D.2    Zanen, J.3    Laurent, G.4    Schaudies, P.R.5    Heuson-Stiennon, J.A.6
  • 35
    • 0026717771 scopus 로고
    • Mechanism of the nephrogenic repair response. Studies on proliferation and vimentin expression after 35S-1,2-dichlorovinyl-L-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells
    • Wallin A, Zhang G, Jones TW, Jaken S, Stevens JL. 1992. Mechanism of the nephrogenic repair response. Studies on proliferation and vimentin expression after 35S-1, 2-dichlorovinyl-L-cysteine nephrotoxicity in vivo and in cultured proximal tubule epithelial cells. Lab Invest 66: 474-484.
    • (1992) Lab Invest , vol.66 , pp. 474-484
    • Wallin, A.1    Zhang, G.2    Jones, T.W.3    Jaken, S.4    Stevens, J.L.5
  • 36
    • 0344236403 scopus 로고    scopus 로고
    • Importance of functional EGF receptors in recovery from acute nephrotoxic injury
    • Wang Z, Chen JK, Wang SW, Moeckel G, Harris RC. 2003. Importance of functional EGF receptors in recovery from acute nephrotoxic injury. J Am Soc Nephrol 14: 3147-3154.
    • (2003) J Am Soc Nephrol , vol.14 , pp. 3147-3154
    • Wang, Z.1    Chen, J.K.2    Wang, S.W.3    Moeckel, G.4    Harris, R.C.5
  • 37
    • 0028273536 scopus 로고
    • Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells
    • Witzgall R, Brown D, Schwarz C, Bonventre JV. 1994. Localization of proliferating cell nuclear antigen, vimentin, c-Fos, and clusterin in the postischemic kidney. Evidence for a heterogenous genetic response among nephron segments, and a large pool of mitotically active and dedifferentiated cells. J Clin Invest 93: 2175-2188.
    • (1994) J Clin Invest , vol.93 , pp. 2175-2188
    • Witzgall, R.1    Brown, D.2    Schwarz, C.3    Bonventre, J.V.4
  • 38
    • 0037025389 scopus 로고    scopus 로고
    • Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation
    • Wu W, Graves LM, Gill GN, Parsons SJ, Samet JM. 2002. Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation. J Biol Chem 277: 24252-24257.
    • (2002) J Biol Chem , vol.277 , pp. 24252-24257
    • Wu, W.1    Graves, L.M.2    Gill, G.N.3    Parsons, S.J.4    Samet, J.M.5
  • 39
    • 49949109721 scopus 로고    scopus 로고
    • Src regulates cell cycle protein expression and renal epithelial cell proliferation via PI3K/Akt signaling-dependent and -independent mechanisms
    • Xing J, Zhang Z, Mao H, Schnellmann RG, Zhuang S. 2008. Src regulates cell cycle protein expression and renal epithelial cell proliferation via PI3K/Akt signaling-dependent and -independent mechanisms. Am J Physiol Renal Physiol 295: F145-F152.
    • (2008) Am J Physiol Renal Physiol , vol.295
    • Xing, J.1    Zhang, Z.2    Mao, H.3    Schnellmann, R.G.4    Zhuang, S.5
  • 40
    • 41149086135 scopus 로고    scopus 로고
    • Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells
    • Zhuang S, Kinsey GR, Rasbach K, Schnellmann RG. 2008. Heparin-binding epidermal growth factor and Src family kinases in proliferation of renal epithelial cells. Am J Physiol Renal Physiol 294: F459-F468.
    • (2008) Am J Physiol Renal Physiol , vol.294
    • Zhuang, S.1    Kinsey, G.R.2    Rasbach, K.3    Schnellmann, R.G.4
  • 41
    • 1942471141 scopus 로고    scopus 로고
    • H2O2-induced transactivation of EGF receptor requires Src and mediates ERK1/2, but not Akt, activation in renal cells
    • Zhuang S, Schnellmann RG. 2004. H2O2-induced transactivation of EGF receptor requires Src and mediates ERK1/2, but not Akt, activation in renal cells. Am J Physiol Renal Physiol 286: F858-F865.
    • (2004) Am J Physiol Renal Physiol , vol.286
    • Zhuang, S.1    Schnellmann, R.G.2
  • 42
    • 34547720044 scopus 로고    scopus 로고
    • Epiregulin promotes proliferation and migration of renal proximal tubular cells
    • Zhuang S, Yan Y, Daubert RA, Schnellmann RG. 2007. Epiregulin promotes proliferation and migration of renal proximal tubular cells. Am J Physiol 293: F219-F226.
    • (2007) Am J Physiol , vol.293
    • Zhuang, S.1    Yan, Y.2    Daubert, R.A.3    Schnellmann, R.G.4
  • 43
    • 20444417067 scopus 로고    scopus 로고
    • p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury
    • Zhuang S, Yan Y, Han J, Schnellmann RG. 2005. p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury. J Biol Chem 280: 21036-21042.
    • (2005) J Biol Chem , vol.280 , pp. 21036-21042
    • Zhuang, S.1    Yan, Y.2    Han, J.3    Schnellmann, R.G.4
  • 44
    • 0033214444 scopus 로고    scopus 로고
    • The EGF receptor as central transducer of heterologous signalling systems
    • Zwick E, Hackel PO, Prenzel N, Ullrich A. 1999. The EGF receptor as central transducer of heterologous signalling systems. Trends Pharmacol Sci 20: 408-412.
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 408-412
    • Zwick, E.1    Hackel, P.O.2    Prenzel, N.3    Ullrich, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.