메뉴 건너뛰기




Volumn 17, Issue 1, 2012, Pages 688-702

The effect of β-carotene supplementation on the pharmacokinetics of nelfinavir and its active metabolite M8 in HIV-1-infected patients

Author keywords

carotene; HIV; Interaction; Nelfinavir; Pharmacokinetics

Indexed keywords

BETA CAROTENE; DRUG DERIVATIVE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; M8 NELFINAVIR; M8-NELFINAVIR; NELFINAVIR;

EID: 84856149488     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17010688     Document Type: Article
Times cited : (13)

References (38)
  • 2
    • 0032501168 scopus 로고    scopus 로고
    • Patterns of use, expenditures, and perceived efficacy of complementary and alternative therapies in HIV-infected patients
    • DOI 10.1001/archinte.158.20.2257
    • Fairfield, K.M.; Eisenberg, D.M.; Davis, R.B.; Libman, H.; Phillips, R.S. Patterns of use, expenditures, and perceived efficacy of complementary and alternative therapies in hiv-infected patients. Arch. Intern. Med. 1998, 158, 2257-2264. (Pubitemid 28512500)
    • (1998) Archives of Internal Medicine , vol.158 , Issue.20 , pp. 2257-2264
    • Fairfield, K.M.1    Eisenberg, D.M.2    Davis, R.B.3    Libman, H.4    Phillips, R.S.5
  • 4
    • 0029162485 scopus 로고
    • The role of oxidative stress in hiv disease
    • Pace, G.W.; Leaf, C.D. The role of oxidative stress in hiv disease. Free Radic Biol. Med. 1995, 19, 523-528.
    • (1995) Free Radic Biol. Med. , vol.19 , pp. 523-528
    • Pace, G.W.1    Leaf, C.D.2
  • 8
    • 84856177233 scopus 로고    scopus 로고
    • Trans-b-carotene and retinoids can effect human cytochrome p450 3a4-mediated metabolism (abstract tupeb4564)
    • Barcelona, Spain 7-12 July
    • Foster, B.; Francovic, A.; Drouin, C.; Akhtar, H.; Cameron, W. Trans-b-carotene and Retinoids can Effect Human Cytochrome p450 3a4-Mediated Metabolism (Abstract tupeb4564). In Proceedings of XIV International AIDS Conference, Barcelona, Spain, 7-12 July 2002.
    • (2002) Proceedings of XIV International AIDS Conference
    • Foster, B.1    Francovic, A.2    Drouin, C.3    Akhtar, H.4    Cameron, W.5
  • 9
    • 11244283586 scopus 로고    scopus 로고
    • Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor
    • DOI 10.1007/s00394-004-0475-1
    • Ruhl, R.; Sczech, R.; Landes, N.; Pfluger, P.; Kluth, D.; Schweigert, F.J. Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane x receptor. Eur. J. Nutr. 2004, 43, 336-343. (Pubitemid 40064269)
    • (2004) European Journal of Nutrition , vol.43 , Issue.6 , pp. 336-343
    • Ruhl, R.1    Sczech, R.2    Landes, N.3    Pfluger, P.4    Kluth, D.5    Schweigert, F.J.6
  • 11
    • 0035086498 scopus 로고    scopus 로고
    • Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: Structural identification, levels in plasma, and antiviral activities
    • DOI 10.1128/AAC.45.4.1086-1093.2001
    • Zhang, K.E.; Wu, E.; Patick, A.K.; Kerr, B.; Zorbas, M.; Lankford, A.; Kobayashi, T.; Maeda, Y.; Shetty, B.; Webber, S. Circulating metabolites of the human immunodeficiency virus protease inhibitor nelfinavir in humans: Structural identification, levels in plasma, and antiviral activities. Antimicrob. Agents Chemother. 2001, 45, 1086-1093. (Pubitemid 32230986)
    • (2001) Antimicrobial Agents and Chemotherapy , vol.45 , Issue.4 , pp. 1086-1093
    • Zhang, K.E.1    Wu, E.2    Patick, A.K.3    Kerr, B.4    Zorbas, M.5    Lankford, A.6    Kobayashi, T.7    Maeda, Y.8    Shetty, B.9    Webber, S.10
  • 19
    • 0028907709 scopus 로고
    • Vitamin e enhances the lymphatic transport of beta-carotene and its conversion to vitamin a in the ferret
    • Wang, X.D.; Marini, R.P.; Hebuterne, X.; Fox, J.G.; Krinsky, N.I.; Russell, R.M. Vitamin e enhances the lymphatic transport of beta-carotene and its conversion to vitamin a in the ferret. Gastroenterol 1995, 108, 719-726.
    • (1995) Gastroenterol , vol.108 , pp. 719-726
    • Wang, X.D.1    Marini, R.P.2    Hebuterne, X.3    Fox, J.G.4    Krinsky, N.I.5    Russell, R.M.6
  • 20
    • 84555172982 scopus 로고    scopus 로고
    • Genetic variations involved in interindividual variability in carotenoid status
    • Borel, P. Genetic variations involved in interindividual variability in carotenoid status. Mol. Nutr. Food Res. 2011, 55, 1-13.
    • (2011) Mol. Nutr. Food Res. , vol.55 , pp. 1-13
    • Borel, P.1
  • 21
    • 0029055448 scopus 로고
    • Phenotyping and genotyping of s-mephenytoin hydroxylase (cytochrome p450 2c19) in a shona population of zimbabwe
    • Masimirembwa, C.; Bertilsson, L.; Johansson, I.; Hasler, J.A.; Ingelman-Sundberg, M. Phenotyping and genotyping of s-mephenytoin hydroxylase (cytochrome p450 2c19) in a shona population of zimbabwe. Clin. Pharmacol. Ther. 1995, 57, 656-661.
    • (1995) Clin. Pharmacol. Ther. , vol.57 , pp. 656-661
    • Masimirembwa, C.1    Bertilsson, L.2    Johansson, I.3    Hasler, J.A.4    Ingelman-Sundberg, M.5
  • 22
    • 0030462277 scopus 로고    scopus 로고
    • S-mephenytoin hydroxylation phenotype and CYP2C19 genotype among Ethiopians
    • DOI 10.1097/00008571-199612000-00005
    • Persson, I.; Aklillu, E.; Rodrigues, F.; Bertilsson, L.; Ingelman-Sundberg, M. S-mephenytoin hydroxylation phenotype and cyp2c19 genotype among ethiopians. Pharmacogenetics 1996, 6, 521-526. (Pubitemid 27032304)
    • (1996) Pharmacogenetics , vol.6 , Issue.6 , pp. 521-526
    • Persson, I.1    Aklillu, E.2    Rodrigues, F.3    Bertilsson, L.4    Ingelman-Sundberg, M.5
  • 23
    • 0030904031 scopus 로고    scopus 로고
    • Frequencies of the defective CYP2C19 alleles responsible for the mephenytoin poor metabolizer phenotype in various Oriental, Caucasian, Saudi Arabian and American black populations
    • DOI 10.1097/00008571-199702000-00008
    • Goldstein, J.A.; Ishizaki, T.; Chiba, K.; de Morais, S.M.; Bell, D.; Krahn, P.M.; Evans, D.A. Frequencies of the defective cyp2c19 alleles responsible for the mephenytoin poor metabolizer phenotype in various oriental, caucasian, saudi arabian and american black populations. Pharmacogenetics 1997, 7, 59-64. (Pubitemid 27153320)
    • (1997) Pharmacogenetics , vol.7 , Issue.1 , pp. 59-64
    • Goldstein, J.A.1    Ishizaki, T.2    Chiba, K.3    De Morais, S.M.F.4    Bell, D.5    Krahn, P.M.6    Price Evans, D.A.7
  • 25
    • 0033866253 scopus 로고    scopus 로고
    • Single and multiple dose pharmacokinetics of nelfinavir and CYP2C19 activity in human immunodeficiency virus-infected patients with chronic liver disease
    • DOI 10.1046/j.1365-2125.2000.00238.x
    • Khaliq, Y.; Gallicano, K.; Seguin, I.; Fyke, K.; Carignan, G.; Bulman, D.; Badley, A.; Cameron, D.W. Single and multiple dose pharmacokinetics of nelfinavir and cyp2c19 activity in human immunodeficiency virus-infected patients with chronic liver disease. Br. J. Clin. Pharmacol. 2000, 50, 108-115. (Pubitemid 30612028)
    • (2000) British Journal of Clinical Pharmacology , vol.50 , Issue.2 , pp. 108-115
    • Khaliq, Y.1    Gallicano, K.2    Seguin, I.3    Fyke, K.4    Carignan, G.5    Bulman, D.6    Badley, A.7    Cameron, D.W.8
  • 27
    • 0021855256 scopus 로고    scopus 로고
    • Oral beta-carotene can increase the number of okt4+ cells in human blood
    • Alexander, M.; Newmark, H.; Miller, R.G. Oral beta-carotene can increase the number of okt4+ cells in human blood. Immunol. Lett. 1985, 9, 221-224.
    • Immunol. Lett. , vol.1985 , Issue.9 , pp. 221-224
    • Alexander, M.1    Newmark, H.2    Miller, R.G.3
  • 28
    • 0032710872 scopus 로고    scopus 로고
    • Modulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables
    • Watzl, B.; Bub, A.; Brandstetter, B.R.; Rechkemmer, G. Modulation of human t-lymphocyte functions by the consumption of carotenoid-rich vegetables. Br. J. Nutr. 1999, 82, 383-389. (Pubitemid 29531268)
    • (1999) British Journal of Nutrition , vol.82 , Issue.5 , pp. 383-389
    • Watzl, B.1    Bub, A.2    Brandstetter, B.R.3    Rechkemmer, G.4
  • 29
    • 27944493200 scopus 로고    scopus 로고
    • Consumption of purple sweet potato leaves modulates human immune response: T-lymphocyte functions, lytic activity of natural killer cell and antibody production
    • Chen, C.M.; Li, S.C.; Lin, Y.L.; Hsu, C.Y.; Shieh, M.J.; Liu, J.F. Consumption of purple sweet potato leaves modulates human immune response: T-lymphocyte functions, lytic activity of natural killer cell and antibody production. World J. Gastroenterol. 2005, 11, 5777-5781.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 5777-5781
    • Chen, C.M.1    Li, S.C.2    Lin, Y.L.3    Hsu, C.Y.4    Shieh, M.J.5    Liu, J.F.6
  • 30
    • 0034882534 scopus 로고    scopus 로고
    • Low-dose supplementation with lycopene or β-carotene does not enhance cell-madiated immunity in healthy free-living elderly humans
    • DOI 10.1038/sj.ejcn.1601187
    • Corridan, B.M.; O'Donoghue, M.; Hughes, D.A.; Morrissey, P.A. Low-dose supplementation with lycopene or beta-carotene does not enhance cell-mediated immunity in healthy free-living elderly humans. Eur. J. Clin. Nutr. 2001, 55, 627-635. (Pubitemid 32776485)
    • (2001) European Journal of Clinical Nutrition , vol.55 , Issue.8 , pp. 627-635
    • Corridan, B.M.1    O'Donoghue, M.2    Hughes, D.A.3    Morrissey, P.A.4
  • 32
    • 0026085868 scopus 로고
    • Effect of β-carotene on lymphocyte subpopulations in elderly humans: Evidence for a dose-response relationship
    • Watson, R.R.; Prabhala, R.H.; Plezia, P.M.; Alberts, D.S. Effect of beta-carotene on lymphocyte subpopulations in elderly humans: Evidence for a dose-response relationship. Am. J. Clin. Nutr. 1991, 53, 90-94. (Pubitemid 21917614)
    • (1991) American Journal of Clinical Nutrition , vol.53 , Issue.1 , pp. 90-94
    • Watson, R.R.1    Prabhala, R.H.2    Plezia, P.M.3    Alberts, D.S.4
  • 34
    • 43649087683 scopus 로고    scopus 로고
    • Extraction and quantification of major carotenoids in processed foods and supplements by liquid chromatography
    • Akhtar, M.; Bryan, M. Extraction and quantification of major carotenoids in processed foods and supplements by liquid chromatography. Food Chem. 2008, 111, 255-261.
    • (2008) Food Chem. , vol.111 , pp. 255-261
    • Akhtar, M.1    Bryan, M.2
  • 35
    • 0035947339 scopus 로고    scopus 로고
    • Analysis of variation in plasma concentrations of nelfinavir and its active metabolite M8 in HIV-positive patients
    • DOI 10.1097/00002030-200105250-00007
    • Baede-van Dijk, P.A.; Hugen, P.W.; Verweij-van Wissen, C.P.; Koopmans, P.P.; Burger, D.M.; Hekster, Y.A. Analysis of variation in plasma concentrations of nelfinavir and its active metabolite m8 in hiv-positive patients. AIDS 2001, 15, 991-998. (Pubitemid 32476666)
    • (2001) AIDS , vol.15 , Issue.8 , pp. 991-998
    • Baede-van Dijk, P.A.1    Hugen, P.W.H.2    Verweij-Van Wissen, C.P.W.G.M.3    Koopmans, P.P.4    Burger, D.M.5    Hekster, Y.A.6
  • 36
    • 0038103469 scopus 로고    scopus 로고
    • Simultaneous determination of the HIV drugs indinavir, amprenavir, saquinavir, ritonavir, lopinavir, nelfinavir, the nelfinavir hydroxymetabolite M8, and nevirapine in human plasma by reversed-phase high-performance liquid chromatography
    • DOI 10.1097/00007691-200306000-00023
    • Droste, J.A.; Verweij-Van Wissen, C.P.; Burger, D.M. Simultaneous determination of the hiv drugs indinavir, amprenavir, saquinavir, ritonavir, lopinavir, nelfinavir, the nelfinavir hydroxymetabolite m8, and nevirapine in human plasma by reversed-phase high-performance liquid chromatography. Ther. Drug Monit. 2003, 25, 393-399. (Pubitemid 36638188)
    • (2003) Therapeutic Drug Monitoring , vol.25 , Issue.3 , pp. 393-399
    • Droste, J.A.H.1    Verweij-Van Wissen, C.P.W.G.M.2    Burger, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.