A community randomized controlled clinical trial of mixed carotenoids and micronutrient supplementation of patients with acquired immunodeficiency syndrome

European Journal of Clinical Nutrition

Volumn 60, Issue 11, 2006, Pages 1266-1276

  Austin, J ^a   Singhal, N ^b   Voigt, R ^c   Smaill, F ^d   Gill, M J ^e   Walmsley, S ^f   Salit, I ^f   Gilmour, J ^g   Schlech, W F ^h   Choudhri, S ⁱ   Rachlis, A ^j   Cohen, J ^k   Trottier, S ^l   Toma, E ^m   Phillips, P ⁿ   Ford, P M ^o   Woods, R ^p   Singer, J ^p   Zarowny, D P ^p   Cameron, D W ^b,q  

^a The Community Research Initiative of Toronto   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c Spectrum Health   (Canada)

^d HAMILTON HEALTH SCIENCES   (Canada)

^e UNIVERSITY OF CALGARY   (Canada)

^f UNIVERSITY HEALTH NETWORK   (Canada)

^g UNIVERSITY OF WESTERN ONTARIO   (Canada)

^h QUEEN ELIZABETH II HEALTH SCIENCES CENTRE   (Canada)

ⁱ UNIVERSITY OF MANITOBA   (Canada)

^j UNIVERSITY OF TORONTO   (Canada)

^k Metropolitan Hospital   (Canada)

^l LAVAL UNIVERSITY   (Canada)

^m CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

ⁿ UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^o QUEEN S UNIVERSITY   (Canada)

^p Canadian HIV Trials Network   (Canada)

^q UNIVERSITY OF OTTAWA   (Canada)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CAROTENE; CAROTENOID; MULTIVITAMIN; NUCLEOSIDE ANALOG; PLACEBO; PROTEINASE INHIBITOR; RETINOL; TRACE ELEMENT;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL TRIAL; COMMUNITY CARE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MORTALITY; MULTICENTER STUDY; MULTIVARIATE ANALYSIS; NUTRITIONAL DEFICIENCY; PREDICTION; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; STATISTICAL SIGNIFICANCE; SURVIVAL RATE; TERTIARY HEALTH CARE; UNSPECIFIED SIDE EFFECT; VITAMIN BLOOD LEVEL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; AGED; ANTI-HIV AGENTS; CAROTENOIDS; CD4 LYMPHOCYTE COUNT; DIETARY SUPPLEMENTS; DISEASE PROGRESSION; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MICRONUTRIENTS; MIDDLE AGED; MULTIVARIATE ANALYSIS; SURVIVAL ANALYSIS; VIRAL LOAD;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 33750541490     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1602447     Document Type: Article

References (52)

1. Alexander M, Newmark H, Miller RG (1985). Oral beta-carotene can increase the number of OKT4+ cells in human blood. Immunol Lett 9, 221-224.
2. Allard JP, Aghdassi E, Chau J, Salit I, Walmsley S (1998). Oxidative stress and plasma antioxidant micronutrients in humans with HIV infection. Am J Clin Nutr 67, 143-147.
3. Baum M, Cassetti L, Bonvehi P, Shor-Posner G, Lu Y, Sauberlich H (1994). Inadequate dietary intake and altered nutrition status in early HIV-1 infection. Nutrition 10, 16-20.
4. Baum MK, Shor-Posner G, Lu Y, Rosner B, Sauberlich HE, Fletcher MA et al. (1995). Micronutrients and HIV-1 disease progression. AIDS 9, 1051-1056.
5. Beach RS, Mantero-Atienza E, Shor-Posner G, Javier JJ, Szapocznik J, Morgan R et al. (1992). Specific nutrient abnormalities in asymptomatic HIV-1 infection. AIDS 6, 701-708.
6. Bendich A (1993). Biological functions of dietary carotenoids. Ann NY Acad Sci 691, 61-67.
7. Bianchi-Santamaria A, Fedeli S, Santamaria L (1992). Short communication: Possible activity of beta-carotene in patients with the AIDS related complex. A pilot study. Med Oncol Tumor Pharmacother 9, 151-153.
8. Blot WJ, Li JY, Taylor PR, Guo W, Dawsey S, Wang GQ et al. (1993). Nutrition intervention trials in Linxian, China: Supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst 85, 1483-1492.
9. Bogden JD, Baker H, Frank O, Perez G, Kemp F, Bruening K et al. (1990). Micronutrient status and human immunodeficiency virus (HIV) infection. Ann NY Acad Sci 587, 189-195.
10. Cameron DW, Heath-Chiozzi M, Danner S, Cohen C, Kravcik S, Maurath C et al. (1998). Randomised placebo-controlled trial of ritonavir in advanced HIV-1 disease. The Advanced HIV Disease Ritonavir Study Group. Lancet 351, 543-549.
11. Centers for Disease Control (1992). 1993 Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. MMWR Recomm Rep 41, 1-19.
12. Constans J, Seigneur M, Blann AD, Renard M, Resplandy F, Amiral J et al. (1998). Effect of the antioxidants selenium and beta-carotene on HIV-related endothelium dysfunction. Thromb Haemost 80, 1015-1017.
13. Coodley GO, Coodley MK, Lusk R, Green TR, Bakke AC, Wilson D et al. (1996). Beta-carotene in HIV infection: An extended evaluation. AIDS 10, 967-973.
14. Coodley GO, Coodley MK, Nelson HD, Loveless MO (1993a). Micronutrient concentrations in the HIV wasting syndrome. AIDS 7, 1595-1600.
15. Coodley GO, Nelson HD, Loveless MO, Folk C (1993b). Beta-carotene in HIV infection. J Acquired Immune Defic Syndr 6, 272-276.
16. Delmas-Beauvieux MC, Peuchant E, Couchouron A, Constans J, Sergeant C, Simonoff M et al. (1996). The enzymatic antioxidant system in blood and glutathione status in human immunodeficiency virus (HIV)-infected patients: Effects of supplementation with selenium or beta-carotene. Am J Clin Nutr 64, 101-107.
17. Fawzi WW, Msamanga GI, Spiegelman D, Wei R, Kapiga S, Villamor E et al. (2004). A randomized trial of multivitamin supplements and HIV disease progression and mortality. N Engl J Med 351, 23-32.
18. Foster B, Franovic A, Drouin CE, Akhtar H, Cameron W (2002). Trans-β-carotene and retinoids can effect human cytochrome P450 3A4-mediated metabolism. Abstract # TuPeB4564. Paper presented at the XIV International AIDS Meeting, Barcelona, 2002.
19. Fryburg DA, Mark RJ, Griffith BP, Askenase PW, Patterson TF (1995). The effect of supplemental beta-carotene on immunologic indices in patients with AIDS: A pilot study. Yale J Biol Med 68, 19-23.
20. Garewal HS, Ampel NM, Watson RR, Prabhala RH, Dols CL (1992). A preliminary trial of beta-carotene in subjects infected with the human immunodeficiency virus. J Nutr 122, 728-732.
21. Hammer SM, Squires KE, Hughes MD, Grimes JM, Demeter LM, Currier JS et al. (1997). A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N Engl J Med 337, 725-733.
22. Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR et al. (1996). Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 334, 1145-1149.
23. Institute of Medicine (2000). Dietary Reference Intakes for Vitamin C, Vitamin E, Selenium, Carotenoids. National Academies Press: Washington, DC.
24. Jiamton S, Pepin J, Suttent R, Filteau S, Mahakkanukrauh B, Hanshaoworakul W, et al. (2003). A randomized trial of the impact of multiple micronutrient supplementation on mortality among HIV-infected individuals living in Bangkok. AIDS 17, 2461-2469.
25. Karyadi E, West CE, Schultink W, Nelwan RH, Gross R, Amin Z et al. (2002). A double-blind, placebo-controlled study of vitamin A and zinc supplementation in persons with tuberculosis in Indonesia: Effects on clinical response and nutritional status. Am J Clin Nutr 75, 720-727.
26. Keating J, Bjarnason I, Somasundaram S, Macpherson A, Francis N, Price AB et al. (1995). Intestinal absorptive capacity, intestinal permeability and jejunal histology in HIV and their relation to diarrhoea. Gut 37, 623-629.
27. Kumwenda N, Miotti PG, Taha TE, Broadhead R, Biggar RJ, Jackson JB et al. (2002). Antenatal vitamin A supplementation increases birth weight and decreases anemia among infants born to human immunodeficiency virus-infected women in Malawi. Clin Infect Dis 35, 618-624.
28. Lacey CJ, Murphy ME, Sanderson MJ, Monteiro EF, Vail A, Schorah CJ (1996). Antioxidant-micronutrients and HIV infection. Int J STD AIDS 7, 485-489.
29. Mathews-Roth MM (1986). Beta-carotene therapy for erythropoietic protoporphyria and other photosensitivity diseases. Biochimie 68, 875-884.
30. Mathews-Roth MM(2000). Erythropoietic protoporphyria: Treatment with antioxidants and potential cure with gene therapy. Methods Enzymol 319, 479-484.
31. Mehendale SM, Shepherd ME, Brookmeyer RS, Semba RD, Divekar AD, Gangakhedkar RR et al. (2001). Low carotenoid concentration and the risk of HIV seroconversion in Pune, India. J Acquired Immune Defic Syndr 26, 352-359.
32. Nimmagadda AP, Burri BJ, Neidlinger T, O'Brien WA, Goetz MB (1998). Effect of oral beta-carotene supplementation on plasma human immunodeficiency virus (HIV) RNA levels and CD4+ cell counts in HIV-infected patients. Clin Infect Dis 27, 1311-1313.
33. O'Brien PC, Fleming TR (1979). A multiple testing procedure for clinical trials. Biometrics 35, 549-556.
34. Omene JA, Easington CR, Glew RH, Prosper M, Ledlie S (1996). Serum beta-carotene deficiency in HIV-infected children. J Natl Med Assoc 88, 789-793.
35. Omenn GS, Goodman GE, Thornquist MD, Balmes J, Cullen MR, Glass A et al. (1996). Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease. N Engl J Med 334, 1150-1155.
36. Phuapradit W, Chaturachinda K, Taneepanichskul S, Sirivarasry J, Khupulsup K, Lerdvuthisopon N (1996). Serum vitamin A and beta-carotene levels in pregnant women infected with human immunodeficiency virus-1. Obstet Gynecol 87, 564-567.
37. Rahman MM, Vermund SH, Wahed MA, Fuchs GJ, Baqui AH, Alvarez JO (2001). Simultaneous zinc and vitamin A supplementation in Bangladeshi children: randomised double blind controlled trial. BMJ 323, 314-318.
38. Sahai J, Gallicano K, Swick L, Tailor S, Garber G, Seguin I et al. (1997). Reduced plasma concentrations of antituberculosis drugs in patients with HIV infection. Ann Intern Med 127, 289-293.
39. Sappey C, Leclercq P, Coudray C, Faure P, Micoud M, Favier A (1994). Vitamin, trace element and peroxide status in HIV seropositive patients: asymptomatic patients present a severe beta-carotene deficiency. Clin Chim Acta 230, 35-42.
40. Semba RD, Graham NM, Caiaffa WT, Margolick JB, Clement L, Vlahov D (1993). Increased mortality associated with vitamin A deficiency during human immunodeficiency virus type 1 infection. Arch Intern Med 153, 2149-2154.
41. Silverman Jr S, Kaugars GE, Gallo J, Thompson JS, Stites DP, Riley WT et al. (1994). Clinical and lymphocyte responses to beta-carotene supplementation in 11 HIV-positive patients with chronic oral candidiasis. Oral Surg Oral Med Oral Pathol 78, 442-447.
42. Skurnick JH, Bogden JD, Baker H, Kemp FW, Sheffet A, Quattrone G et al. (1996). Micronutrient profiles in HIV-1-infected heterosexual adults. J Acquired Immune Defic Syndr Hum Retrovirol 12, 75-83.
43. Steck-Scott S, Forman MR, Sowell A, Borkowf CB, Albert PS, Slattery M et al. (2004). Carotenoids, vitamin A and risk of adenomatous polyp recurrence in the polyp prevention trial. Int J Cancer 112, 295-305.
44. Stephensen CB (2003). Vitamin A, beta-carotene, and mother-to-child transmission of HIV. Nutr Rev 61, 280-284.
45. Tang AM, Graham NM, Kirby AJ, McCall LD, Willett WC, Saah AJ (1993). Dietary micronutrient intake and risk of progression to acquired immunodeficiency syndrome (AIDS) in human immunodeficiency virus type 1 (HIV-1)-infected homosexual men. Am J Epidemiol 138, 937-951.
46. Tang AM, Graham NM, Saah AJ (1996). Effects of micronutrient intake on survival in human immunodeficiency virus type 1 infection. Am J Epidemiol 143, 1244-1256.
47. The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group (1994). The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med 330, 1029-1035.
48. Toma E, Devost D, Chow Lan N, Bhat PV (2001). HIV-protease inhibitors alter retinoic acid synthesis. AIDS 15, 1979-1984.
49. Turpin JA, Vargo M, Meltzer MS (1992). Enhanced HIV-1 replication in retinoid-treated monocytes. Retinoid effects mediated through mechanisms related to cell differentiation and to a direct transcriptional action on viral gene expression. J Immunol 148, 2539-2546.
50. Ullrich R, Schneider T, Heise W, Schmidt W, Averdunk R, Riecken EO et al. (1994). Serum carotene deficiency in HIV-infected patients. Berlin Diarrhoea/Wasting Syndrome Study Group. AIDS 8, 661-665.
51. Villamor E, Fawzi WW (2000). Vitamin A supplementation: Implications for morbidity and mortality in children. J Infect Dis 182 (Suppl 1), S122-33.
52. West Jr KP, Katz J, Khatry SK, LeClerq SC, Pradhan EK, Shrestha SR et al. (1999). Double blind, cluster randomised trial of low dose supplementation with vitamin A or beta carotene on mortality related to pregnancy in Nepal. The NNIPS-2 Study Group. BMJ 318, 570-575.