Comparative computational studies of 3,4-dihydro-2,6-diaryl-4-oxo- pyrimidine-5-carbonitrile derivatives as potential antinociceptive agents

Molecules

Volumn 17, Issue 1, 2012, Pages 809-819

  Dos Anjos, Janaína V ^a   Srivastava, Rajendra M ^a   Costa Silva, Joao H ^a   Scotti, Luciana ^b   Scotti, Marcus T ^b   Wanderley, Almir G ^a   Leite, Elisa Soares ^a   De Melo, Sebastiao J ^a   Mendonça Jr , Francisco J B ^c  

^a FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^c STATE UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

4 (3H) pyrimidinones; Antinociceptive activity; Density functional theory; Molecular modeling

Indexed keywords

3,4 DIHYDRO 2 (4 CHLOROPHENYL) 6 (4 METHOXYPHENYL) 4 OXO PYRIMIDINE 5 CARBONITRILE; 3,4 DIHYDRO 2 PHENYL 6 PARA FLUOROPHENYL 4 OXO PYRIMIDINE 5 CARBONITRILE; 3,4-DIHYDRO-2-(4-CHLOROPHENYL)-6-(4-METHOXYPHENYL)-4-OXO-PYRIMIDINE-5-CARBONITRILE; 3,4-DIHYDRO-2-PHENYL-6-PARA-FLUOROPHENYL-4-OXO-PYRIMIDINE-5-CARBONITRILE; ACETIC ACID; ANALGESIC AGENT; NITRILE; PYRIMIDINE DERIVATIVE;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; COMPUTER SIMULATION; DRUG SCREENING; MALE; MOUSE; PAIN;

ACETIC ACID; ANALGESICS; ANIMALS; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; MALE; MICE; MODELS, MOLECULAR; NITRILES; PAIN; PYRIMIDINES;

EID: 84856143924     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules17010809     Document Type: Article

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