Synthesis and biological activity of novel pyrimidinone containing thiazolidinedione derivatives

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 8, 2002, Pages 2671-2680

  Madhavan, Gurram R ^a   Chakrabarti, Ranjan ^a   Vikramadithyan, Reeba K ^a   Mamidi, Rao N V S ^a   Balraju, V ^a   Rajesh, B M ^a   Misra, Parimal ^a   Kumar, Sunil K B ^a   Lohray, Braj B ^a   Lohray, Vidya B ^a   Rajagopalan, Ramanujam ^a  

^a DR REDDY S RESEARCH FOUNDATION   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 [4 [2 [2 ETHYL 4 METHYL 6 OXO 1,6 DIHYDRO 1 PYRIMIDINYL]ETHOXY]PHENYLMETHYL]THIAZOLIDINE 2,4 DIONE; GLUCOSE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; ROSIGLITAZONE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE; 2,4-THIAZOLIDINEDIONE; ANTIDIABETIC AGENT; CELL RECEPTOR; INSULIN; PYRIMIDINONE DERIVATIVE; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG SYNTHESIS; EMBRYO; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; RAT; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; BLOOD; CELL LINE; MOUSE MUTANT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TRANSACTIVATION; WISTAR RAT;

RATTUS NORVEGICUS;

ANIMALS; BLOOD GLUCOSE; CELL LINE; HYPOGLYCEMIC AGENTS; INSULIN; MICE; MICE, OBESE; PYRIMIDINONES; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIAZOLIDINEDIONES; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 0036283721     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00107-4     Document Type: Article

References (14)

1. Liver damage warning for troglitazone
2. Canada reports 166 ADRs with Avandia