Syntheses of vanadyl and zinc(II) complexes of 1-hydroxy-4,5,6-substituted 2(1H)-pyrimidinones and their insulin-mimetic activities

Journal of Inorganic Biochemistry

Volumn 100, Issue 2, 2006, Pages 260-269

  Yamaguchi, Mika ^a   Wakasugi, Kei ^a   Saito, Ryota ^a   Adachi, Yusuke ^b   Yoshikawa, Yutaka ^b   Sakurai, Hiromu ^b   Katoh, Akira ^a  

^a SEIKEI UNIVERSITY   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

2(1H) pyrimidinone; Hydrophobic hydrophilic balance; Insulin mimetic activity; Oral glucose tolerance test; Rat adipocyte; STZ rat; Vanadyl(IV) complex; Zinc(II) complex

Indexed keywords

1 BENZYLOXY 4 (1',2',4' TRIAZOL 1' YL) 2 (1H)PYRIMIDINONE; ADRENALIN; BIS(1,2 DIHYDRO 2 OXO 1 PYRIMIDINOLATO) OXOVANADIUM; BIS(1,2 DIHYDRO 2 OXO 1 PYRIMIDINOLATO)ZINC; BIS(1,2 DIHYDRO 4 BUTYLAMINO 2 OXO 1 PYRIMIDINOLATO)ZINC; BIS(1,2 DIHYDRO 4 ETHYLAMINO 2 OXO 1 PYRIMIDINOLATO)ZINC; BIS(1,2 DIHYDRO 4 HEXYLAMINO 2 OXO 1 PYRIMIDINOLATO)ZINC; BIS(1,2 DIHYDRO 4 METHOXYCARBONYLMETHYLAMINO 2 OXO 1 PYRIMIDINOLATO)ZINC; BIS(1,2 DIHYDRO 4 OCTYLAMINO 2 OXO 1 PYRIMIDINOLATO)ZINC; BIS(1,2 DIHYDRO 4,5,6 TRIMETHYL 2 OXO 1 PYRIMIDINOLATO)OXOVANADIUM; BIS(1,2 DIHYDRO 4,6 BISTRIFLUOROMETHYL 2 OXO 1 PYRIMIDINOLATO)HYDROXYLOXOVANADIUM; BIS(1,2 DIHYDRO 4,6 DIETHYL 2 OXO 1 PYRIMIDINOLATO)OXOVANADIUM; BIS(1,2 DIHYDRO 4,6 DIMETHYL 2 OXO 1 PYRIMIDINOLATO)OXOVANADIUM; BIS(1,2 DIHYDRO 4,6 DIMETHYL 2 OXO 1 PYRIMIDINOLATO)ZINC; BIS(1,2 DIHYDRO 4,6 DIMETHYL 2 OXO 5 PROPYL 1 PYRIMIDINOLATO)OXOVANADIUM; BIS(1,2 DIHYDRO 4,6 DIMETHYL 5 ETHYL 2 OXO 1 PYRIMIDINOLATO)OXOVANADIUM; BIS(1,2 DIHYDRO 5 BENZYL 4,6 DIMETHYL 2 OXO 1 PYRIMIDINOLATO)OXOVANADIUM; FATTY ACID; GLUCOSE; KETONE; METAL COMPLEX; N BENZYLOXYUREA; PYRIMIDINONE DERIVATIVE; UNCLASSIFIED DRUG; UREA; VANADYL DERIVATIVE; ZINC COMPLEX;

ADIPOCYTE; ANIMAL EXPERIMENT; ARTICLE; COMBUSTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; GLUCOSE BLOOD LEVEL; HYDROPHOBICITY; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; MALE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; SUBSTITUTION REACTION; ULTRAVIOLET SPECTROSCOPY;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; DRUG EVALUATION, PRECLINICAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; HYPOGLYCEMIC AGENTS; INHIBITORY CONCENTRATION 50; INSULIN; LIGANDS; MALE; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PYRIMIDINONES; RATS; RATS, WISTAR; VANADATES; ZINC;

ANIMALIA;

EID: 30544433446     PISSN: 01620134     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jinorgbio.2005.11.010     Document Type: Article

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