Autoimmunity induced by human cytomegalovirus in patients with systemic lupus erythematosus

Arthritis Research and Therapy

Volumn 14, Issue 1, 2012, Pages

  Söderberg Nauclér, Cecilia ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY; ANTICD13 ANTIBODY; ANTINUCLEAR ANTIBODY; ARACHIDONATE 5 LIPOXYGENASE; AUTOANTIBODY; COMPLEMENT COMPONENT C3B; CORTISONE; CYCLOOXYGENASE 2; CYTOMEGALOVIRUS ANTIGEN PP65; DOUBLE STRANDED DNA; EPITOPE; GAMMA INTERFERON; GANCICLOVIR; IMMUNOGLOBULIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LEUKOTRIENE B4; NUCLEAR PROTEIN; PHOSPHOLIPID ANTIBODY; PROSTAGLANDIN E2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL THERAPY; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CENTRIOLE; CHROMAFFIN CELL; CHROMATIN; CYTOMEGALOVIRUS INFECTION; DISEASE ACTIVITY; DISEASE SEVERITY; EDITORIAL; ENCEPHALITIS; ENDOTHELIUM CELL; ENTERITIS; GENE MUTATION; GLOMERULONEPHRITIS; GLOMERULUS; GUILLAIN BARRE SYNDROME; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN CYTOMEGALOVIRUS; IMMUNOGENICITY; IMMUNOREACTIVITY; INFECTION; MITOSIS SPINDLE; MOLECULAR MIMICRY; MYOSITIS; NONHUMAN; PROTEIN INTERACTION; PSORIASIS; RHEUMATOID ARTHRITIS; SCLERODERMA; SINUSITIS; SKIN BIOPSY; SMOOTH MUSCLE FIBER; SYSTEMIC LUPUS ERYTHEMATOSUS; VASCULITIS; WEGENER GRANULOMATOSIS;

EID: 84856142167     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar3525     Document Type: Editorial

References (11)

1. Hsieh AH, Jhou YJ, Liang CT, Chang M, Wang SL. Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice. Arthritis Res Ther 2011, 13:R162. 10.1186/ar3481, 21989080.
2. Varani S, Landini MP. Cytomegalovirus-induced immunopathology and its clinical consequences. Herpesviridae 2011, 2:6. 10.1186/2042-4280-2-6, 3082217, 21473750.
3. Qiu H, Straat K, Rahbar A, Wan M, Soderberg-Naucler C, Haeggstrom JZ. Human CMV infection induces 5-lipoxygenase expression and leukotriene B4 production in vascular smooth muscle cells. J Exp Med 2008, 205:19-24. 10.1084/jem.20070201, 2234367, 18180307.
4. Zhu H, Cong JP, Yu D, Bresnahan WA, Shenk TE. Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication. Proc Natl Acad Sci USA 2002, 99:3932-3937. 10.1073/pnas.052713799, 122626, 11867761.
5. Slinger E, Maussang D, Schreiber A, Siderius M, Rahbar A, Fraile-Ramos A, Lira SA, Soderberg-Naucler C, Smit MJ. HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis. Sci Signal 2010, 3:ra58. 10.1126/scisignal.2001180, 20682912.
6. Baccala R, Hoebe K, Kono DH, Beutler B, Theofilopoulos AN. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med 2007, 13:543-551. 10.1038/nm1590, 17479100.
7. Kono DH, Haraldsson MK, Lawson BR, Pollard KM, Koh YT, Du X, Arnold CN, Baccala R, Silverman GJ, Beutler BA, Theofilopoulos AN. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci USA 2009, 106:12061-12066. 10.1073/pnas.0905441106, 2715524, 19574451.
8. Bessou G, Traub S, Robbins SH, Uematsu S, Akira S, Alexopoulou L, Dalod M. Cutting edge: overlapping functions of TLR7 and TLR9 for innate defense against a herpesvirus infection. J Immunol 2008, 180:5799-5803.
9. Varani S, Cederarv M, Feld S, Tammik C, Frascaroli G, Landini MP, Soderberg-Naucler C. Human cytomegalovirus differentially controls B cell and T cell responses through effects on plasmacytoid dendritic cells. J Immunol 2007, 179:7767-7776.
10. Nahum A, Dadi H, Bates A, Roifman CM. The L412F variant of Toll-like receptor 3 (TLR3) is associated with cutaneous candidiasis, increased susceptibility to cytomegalovirus, and autoimmunity. J Allergy Clin Immunol 2011, 127:528-531. 10.1016/j.jaci.2010.09.031, 21093032.
11. Varani S, Mastroianni A, Frascaroli G, Tammik C, Rahbar A, Christensson M, Rossini G, Landini MP, Soderberg-Naucler C. Generalized Wegener's granulomatosis in an immunocompetent adult after cytomegalovirus mononucleosis and bacterial urinary tract infection. Arthritis Rheum 2009, 60:1558-1562. 10.1002/art.24487, 19404959.