메뉴 건너뛰기




Volumn 24, Issue 1, 2012, Pages 16-22

Clinical and research issues in neonatal anemia and thrombocytopenia

Author keywords

anemia of prematurity; erythropoietin; neonatal thrombocytopenia; thrombopoietin; transfusions

Indexed keywords

ERYTHROPOIETIN; HEMOPOIETIC GROWTH FACTOR; RECOMBINANT HEMOPOIETIC GROWTH FACTOR; THROMBOPOIETIN; UNCLASSIFIED DRUG;

EID: 84856111106     PISSN: 10408703     EISSN: 1531698X     Source Type: Journal    
DOI: 10.1097/MOP.0b013e32834ee5cc     Document Type: Review
Times cited : (10)

References (44)
  • 2
    • 33747883061 scopus 로고    scopus 로고
    • The premature infants in need of transfusion PINT study: A randomized controlled trial of a restrictive low versus liberal high transfusion threshold for extremely low birth weight infants
    • Kirpalani H, Whyte RK, Andersen C, et al. The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006; 149:301-307.
    • (2006) J. Pediatr. , vol.149 , pp. 301-307
    • Kirpalani, H.1    Whyte, R.K.2    Andersen, C.3
  • 3
    • 67650717918 scopus 로고    scopus 로고
    • Effect of blood transfusions on the outcome of very low body weight preterm infants under two different transfusion criteria
    • Chen HL, Tseng HI, Lu CC, et al. Effect of blood transfusions on the outcome of very low body weight preterm infants under two different transfusion criteria. Pediatr Neonatol 2009; 50:110-116.
    • (2009) Pediatr. Neonatol. , vol.50 , pp. 110-116
    • Chen, H.L.1    Tseng, H.I.2    Lu, C.C.3
  • 4
    • 59449094253 scopus 로고    scopus 로고
    • Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion
    • Whyte RK, Kirpalani H, Asztalos EV, et al. Neurodevelopmental outcome of extremely low birth weight infants randomly assigned to restrictive or liberal hemoglobin thresholds for blood transfusion. Pediatrics 2009; 123:207-213.
    • (2009) Pediatrics , vol.123 , pp. 207-213
    • Whyte, R.K.1    Kirpalani, H.2    Asztalos, E.V.3
  • 5
    • 79960451460 scopus 로고    scopus 로고
    • Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion
    • In this study investigators evaluated neurocognitive and academic functioning in 56 school-age children who were originally enrolled in the Iowa RBC transfusion trial This study found that infants randomized as neonates to the liberal transfusion arm performed significantly worse in tests of associative verbal fluency visual memory and reading compared with infants randomized to the restrictive arm
    • McCoy TE, Conrad AL, Richman LC, et al. Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion. Child Neuropsychol 2011; 17:347-367. In this study, investigators evaluated neurocognitive and academic functioning in 56 school-age children who were originally enrolled in the Iowa RBC transfusion trial. This study found that infants randomized as neonates to the liberal transfusion arm performed significantly worse in tests of associative verbal fluency, visual memory, and reading compared with infants randomized to the restrictive arm.
    • (2011) Child. Neuropsychol. , vol.17 , pp. 347-367
    • McCoy, T.E.1    Conrad, A.L.2    Richman, L.C.3
  • 6
    • 79955558491 scopus 로고    scopus 로고
    • Long-term outcome of brain structure in premature infants: Effects of liberal vs restricted red blood cell transfusions
    • This study evaluated brain volume measurements in MRI scans performed at 12 years of age in former preterm infants randomized to the liberal vs restrictive RBC transfusion arm in the Iowa trial Brain volumes were significantly smaller in infants in the liberal group particularly in girls compared with those in the restrictive group
    • Nopoulos PC, Conrad AL, Bell EF, et al. Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions. Arch Pediatr Adolesc Med 2011; 165:443-450. This study evaluated brain volume measurements in MRI scans performed at 12 years of age in former preterm infants randomized to the liberal vs. restrictive RBC transfusion arm in the Iowa trial. Brain volumes were significantly smaller in infants in the liberal group, particularly in girls, compared with those in the restrictive group.
    • (2011) Arch. Pediatr. Adolesc. Med. , vol.165 , pp. 443-450
    • Nopoulos, P.C.1    Conrad, A.L.2    Bell, E.F.3
  • 8
    • 77951690244 scopus 로고    scopus 로고
    • Is transfusion-associated necrotizing enterocolitis an authentic pathogenic entity
    • This is one of the largest studies describing the development of necrotizing enterocolitis within 48 h of a RBC transfusion
    • Christensen RD, Lambert DK, Henry E, et al. Is 'transfusion-associated necrotizing enterocolitis' an authentic pathogenic entity? Transfusion 2010; 50:1106-1112. This is one of the largest studies describing the development of necrotizing enterocolitis within 48 h of a RBC transfusion.
    • (2010) Transfusion , vol.50 , pp. 1106-1112
    • Christensen, R.D.1    Lambert, D.K.2    Henry, E.3
  • 9
    • 78449278152 scopus 로고    scopus 로고
    • Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants
    • e1-3
    • Josephson CD, Wesolowski A, Bao G, et al. Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants? J Pediatr 2010; 157:972-978. e1-3.
    • (2010) J. Pediatr. , vol.157 , pp. 972-978
    • Josephson, C.D.1    Wesolowski, A.2    Bao, G.3
  • 10
    • 79951575831 scopus 로고    scopus 로고
    • Transfusion-related acute gut injury: Necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion
    • This study proposed the hypothesis that transfusion-associated NEC could have similar pathogenesis to transfusion-associated lung injury and coined the now popular term transfusion-associated gut Injury TRAGI
    • Blau J, Calo JM, Dozor D, et al. Transfusion-related acute gut injury: necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion. J Pediatr 2011; 158:403-409. This study proposed the hypothesis that transfusion-associated NEC could have similar pathogenesis to transfusion-associated lung injury, and coined the now popular term 'Transfusion-Associated Gut Injury' (TRAGI).
    • (2011) J. Pediatr. , vol.158 , pp. 403-409
    • Blau, J.1    Calo, J.M.2    Dozor, D.3
  • 11
    • 79953319603 scopus 로고    scopus 로고
    • Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants
    • This is one of the largest studies describing the development of necrotizing enterocolitis within 48 h of a RBC transfusion.
    • Paul DA, Mackley A, Novitsky A, et al. Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants. Pediatrics 2011; 127:635-641. This is one of the largest studies describing the development of necrotizing enterocolitis within 48 h of a RBC transfusion.
    • (2011) Pediatrics , vol.127 , pp. 635-641
    • Paul, D.A.1    Mackley, A.2    Novitsky, A.3
  • 12
    • 79952315642 scopus 로고    scopus 로고
    • Association of necrotizing enterocolitis with anemia and packed red blood cell transfusions in preterm infants
    • Singh R, Visintainer PF, Frantz ID 3rd, et al. Association of necrotizing enterocolitis with anemia and packed red blood cell transfusions in preterm infants. J Perinatol 2011; 31:176-182.
    • (2011) J. Perinatol. , vol.31 , pp. 176-182
    • Singh, R.1    Visintainer, P.F.2    Frantz III, I.D.3
  • 13
    • 79952316970 scopus 로고    scopus 로고
    • Red blood cell transfusion feeding and necrotizing enterocolitis in preterm infants
    • El-Dib M, Narang S, Lee E, et al. Red blood cell transfusion, feeding and necrotizing enterocolitis in preterm infants. J Perinatol 2011; 31:183-187.
    • (2011) J. Perinatol. , vol.31 , pp. 183-187
    • El-Dib, M.1    Narang, S.2    Lee, E.3
  • 14
    • 73949089031 scopus 로고    scopus 로고
    • Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis
    • Gladwin MT, Kim-Shapiro DB. Storage lesion in banked blood due to hemolysis-dependent disruption of nitric oxide homeostasis. Curr Opin Hematol 2009; 16:515-523.
    • (2009) Curr. Opin. Hematol. , vol.16 , pp. 515-523
    • Gladwin, M.T.1    Kim-Shapiro, D.B.2
  • 15
    • 59949103717 scopus 로고    scopus 로고
    • Blood transfusion alters the superior mesenteric artery blood flow velocity response to feeding in premature infants
    • Krimmel GA, Baker R, Yanowitz TD. Blood transfusion alters the superior mesenteric artery blood flow velocity response to feeding in premature infants. Am J Perinatol 2009; 26:99-105.
    • (2009) Am. J. Perinatol. , vol.26 , pp. 99-105
    • Krimmel, G.A.1    Baker, R.2    Yanowitz, T.D.3
  • 16
    • 77953085101 scopus 로고    scopus 로고
    • Blood transfusions increase cerebral splanchnic and renal oxygenation in anemic preterm infants
    • Dani C, Pratesi S, Fontanelli G, et al. Blood transfusions increase cerebral, splanchnic, and renal oxygenation in anemic preterm infants. Transfusion 2010; 50:1220-1226.
    • (2010) Transfusion , vol.50 , pp. 1220-1226
    • Dani, C.1    Pratesi, S.2    Fontanelli, G.3
  • 18
    • 58249139604 scopus 로고    scopus 로고
    • Platelet transfusion practices among neonatologists in the united states and canada: Results of a survey
    • Josephson CD, Su LL, Christensen RD, et al. Platelet transfusion practices among neonatologists in the United States and Canada: results of a survey. Pediatrics 2009; 123:278-285.
    • (2009) Pediatrics , vol.123 , pp. 278-285
    • Josephson, C.D.1    Su, L.L.2    Christensen, R.D.3
  • 19
    • 83555174474 scopus 로고    scopus 로고
    • Platelet transfusions in neonates: Practices in the united states vary significantly from those in austria germany and Switzerland
    • Epub ahead of print this study is of importance because it exposed marked differences in platelet transfusion practices between US and European neonatologists and suggested that a significantly higher number of infants receive platelet transfusions in the United States compared with some European countries only on the basis of practice differences
    • Cremer M, Sola-Visner M, Roll S, et al. Platelet transfusions in neonates: practices in the United States vary significantly from those in Austria, Germany, and Switzerland. Transfusion 2011. [Epub ahead of print] This study is of importance because it exposed marked differences in platelet transfusion practices between US and European neonatologists, and suggested that a significantly higher number of infants receive platelet transfusions in the United States compared with some European countries, only on the basis of practice differences.
    • (2011) Transfusion
    • Cremer, M.1    Sola-Visner, M.2    Roll, S.3
  • 21
    • 70350491187 scopus 로고    scopus 로고
    • Prospective observational study of outcomes in neonates with severe thrombocytopenia
    • Stanworth SJ, Clarke P, Watts T, et al. Prospective, observational study of outcomes in neonates with severe thrombocytopenia. Pediatrics 2009; 124:e826-e834.
    • (2009) Pediatrics , vol.124
    • Stanworth, S.J.1    Clarke, P.2    Watts, T.3
  • 22
    • 71949087811 scopus 로고    scopus 로고
    • Severe thrombocytopenia in the NICU
    • Baer VL, Lambert DK, Henry E, et al. Severe Thrombocytopenia in the NICU. Pediatrics 2009; 124:e1095-e1100.
    • (2009) Pediatrics , vol.124
    • Baer, V.L.1    Lambert, D.K.2    Henry, E.3
  • 23
    • 79751534629 scopus 로고    scopus 로고
    • Thrombocytopenia in neonates and the risk of intraventricular hemorrhage: A retrospective cohort study
    • This study found that neonates with thrombocytopenia in general have a significantly higher mortality and risk of IVH compared with nonthrombocytopenic neonates However there was no association between the severity of the thrombocytopenia and these risks
    • von Lindern JS, van den Bruele T, Lopriore E, et al. Thrombocytopenia in neonates and the risk of intraventricular hemorrhage: a retrospective cohort study. BMC Pediatrics 2011; 11:16. This study found that neonates with thrombocytopenia, in general, have a significantly higher mortality and risk of IVH compared with nonthrombocytopenic neonates. However, there was no association between the severity of the thrombocytopenia and these risks.
    • (2011) BMC Pediatrics , vol.11 , pp. 16
    • Von Lindern, J.S.1    Van Den Bruele, T.2    Lopriore, E.3
  • 24
    • 33845971313 scopus 로고    scopus 로고
    • Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants
    • Ohlsson A, Aher SM. Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2006; 3:CD004863.
    • (2006) Cochrane Database Syst. Rev. , vol.3
    • Ohlsson, A.1    Aher, S.M.2
  • 25
    • 78149469551 scopus 로고    scopus 로고
    • Anaemia of prematurity: Pathophysiology and treatment
    • This review provides a contemporary overview of the pathophysiology and management of neonatal anemia including transfusion therapy and the use of Epo
    • Strauss RG. Anaemia of prematurity: pathophysiology and treatment. Blood Rev 2011; 24:221-225. This review provides a contemporary overview of the pathophysiology and management of neonatal anemia, including transfusion therapy and the use of Epo.
    • (2011) Blood Rev. , vol.24 , pp. 221-225
    • Strauss, R.G.1
  • 26
    • 33845971313 scopus 로고    scopus 로고
    • Late erythropoietin for preventing red blood cell transfusion in preterm and or low birth weight infants
    • Aher S, Ohlsson A. Late erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants. Cochrane Database Syst Rev 2006; 3:CD004868.
    • (2006) Cochrane Database Syst. Rev. , vol.3
    • Aher, S.1    Ohlsson, A.2
  • 27
    • 45449114982 scopus 로고    scopus 로고
    • Human recombinant erythropoietin and the incidence of retinopathy of prematurity: A multiple regression model
    • DOI 10.1016/j.jaapos.2007.08.009, PII S1091853107004491
    • Suk KK, Dunbar JA, Liu A, et al. Human recombinant erythropoietin and the incidence of retinopathy of prematurity: a multiple regression model. J AAPOS 2008; 12:233-238. (Pubitemid 351853461)
    • (2008) Journal of AAPOS , vol.12 , Issue.3 , pp. 233-238
    • Suk, K.K.1    Dunbar, J.A.2    Liu, A.3    Daher, N.S.4    Leng, C.K.5    Leng, J.K.6    Lim, P.7    Weller, S.8    Fayard, E.9
  • 29
    • 49849104424 scopus 로고    scopus 로고
    • A phase I II trial of high-dose erythropoietin in extremely low birth weight infants: Pharmacokinetics and safety
    • Juul SE, McPherson RJ, Bauer LA, et al. A phase I/II trial of high-dose erythropoietin in extremely low birth weight infants: pharmacokinetics and safety. Pediatrics 2008; 122:383-391.
    • (2008) Pediatrics , vol.122 , pp. 383-391
    • Juul, S.E.1    McPherson, R.J.2    Bauer, L.A.3
  • 30
    • 49849096888 scopus 로고    scopus 로고
    • An approach to using recombinant erythropoietin for neuroprotection in very preterm infants
    • Fauchere JC, Dame C, Vonthein R, et al. An approach to using recombinant erythropoietin for neuroprotection in very preterm infants. Pediatrics 2008; 122:375-382.
    • (2008) Pediatrics , vol.122 , pp. 375-382
    • Fauchere, J.C.1    Dame, C.2    Vonthein, R.3
  • 31
    • 67749137294 scopus 로고    scopus 로고
    • Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy
    • Zhu C, Kang W, Xu F, et al. Erythropoietin improved neurologic outcomes in newborns with hypoxic-ischemic encephalopathy. Pediatrics 2009; 124:e218-e226.
    • (2009) Pediatrics , vol.124
    • Zhu, C.1    Kang, W.2    Xu, F.3
  • 32
    • 0036530040 scopus 로고    scopus 로고
    • Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
    • DOI 10.1182/blood.V99.7.2599
    • Basser RL, O'Flaherty E, Green M, et al. Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood 2002; 99:2599-2602. (Pubitemid 34525451)
    • (2002) Blood , vol.99 , Issue.7 , pp. 2599-2602
    • Basser, R.L.1    O'Flaherty, E.2    Green, M.3    Edmonds, M.4    Nichol, J.5    Menchaca, D.M.6    Cohen, B.7    Begley, C.G.8
  • 33
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • Li J, Yang C, Xia Y, et al. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood 2001; 98:3241-3248.
    • (2001) Blood , vol.98 , pp. 3241-3248
    • Li, J.1    Yang, C.2    Xia, Y.3
  • 36
    • 79960114674 scopus 로고    scopus 로고
    • A randomized double-blind study of romiplostim to determine its safety and efficacy in children with immune thrombocytopenia
    • This is the first study on the use of thrombopoietic growth factors in pediatric patients It showed that the use of romiplostim in children aged 1-18 years with chronic ITP is effective and well tolerated However no patients younger than a year were enrolled
    • Bussel JB, Buchanan GR, Nugent DJ, et al. A randomized, double-blind study of romiplostim to determine its safety and efficacy in children with immune thrombocytopenia. Blood 2011; 118:28-36. This is the first study on the use of thrombopoietic growth factors in pediatric patients. It showed that the use of romiplostim in children aged 1-18 years with chronic ITP is effective and well tolerated. However, no patients younger than a year were enrolled.
    • (2011) Blood , vol.118 , pp. 28-36
    • Bussel, J.B.1    Buchanan, G.R.2    Nugent, D.J.3
  • 37
    • 78649666559 scopus 로고    scopus 로고
    • Increasing platelets without transfusion: Is it time to introduce novel thrombopoietic agents in neonatal care
    • This review discusses in detail the potential limitations and concerns associated with the use of thrombopoietic growth factors in neonates
    • Sallmon H, Gutti RK, Ferrer-Marin F, et al. Increasing platelets without transfusion: is it time to introduce novel thrombopoietic agents in neonatal care? J Perinatol 2010; 30:765-769. This review discusses in detail the potential, limitations, and concerns associated with the use of thrombopoietic growth factors in neonates.
    • (2010) J. Perinatol. , vol.30 , pp. 765-769
    • Sallmon, H.1    Gutti, R.K.2    Ferrer-Marin, F.3
  • 38
    • 58549114853 scopus 로고    scopus 로고
    • Immature platelet fraction as novel laboratory parameter predicting the course of neonatal thrombocytopenia
    • Cremer M, Paetzold J, Schmalisch G, et al. Immature platelet fraction as novel laboratory parameter predicting the course of neonatal thrombocytopenia. Br J Haematol 2009; 144:619-621.
    • (2009) Br. J. Haematol. , vol.144 , pp. 619-621
    • Cremer, M.1    Paetzold, J.2    Schmalisch, G.3
  • 39
    • 78650669297 scopus 로고    scopus 로고
    • Eltrombopag for the treatment of the inherited thrombocytopenia deriving from MYH9 mutations
    • Pecci A, Gresele P, Klersy C, et al. Eltrombopag for the treatment of the inherited thrombocytopenia deriving from MYH9 mutations. Blood 2011; 116:5832-5837.
    • (2011) Blood , vol.116 , pp. 5832-5837
    • Pecci, A.1    Gresele, P.2    Klersy, C.3
  • 40
    • 79954584820 scopus 로고    scopus 로고
    • Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes
    • This study demonstrated that neonatal megakaryocytes exhibit a different pattern of maturation compared with adultmegakaryocytes characterized by rapid proliferation and full terminal maturation without polyploidization These findings challenged the widely accepted notion that neonatal megakaryocytes are immature
    • Liu ZJ, Italiano J Jr, Ferrer-Marin F, et al. Developmental differences in megakaryocytopoiesis are associated with up-regulated TPO signaling through mTOR and elevated GATA-1 levels in neonatal megakaryocytes. Blood 2011; 117:4106-4117. This study demonstrated that neonatal megakaryocytes exhibit a different pattern of maturation compared with adultmegakaryocytes, characterized by rapid proliferation and full terminal maturation without polyploidization. These findings challenged the widely accepted notion that neonatal megakaryocytes are 'immature'.
    • (2011) Blood , vol.117 , pp. 4106-4117
    • Liu, Z.J.1    Italiano Jr., J.2    Ferrer-Marin, F.3
  • 41
    • 33751170220 scopus 로고    scopus 로고
    • Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes
    • Pastos KM, Slayton WB, Rimsza LM, et al. Differential effects of recombinant thrombopoietin and bone marrow stromal-conditioned media on neonatal versus adult megakaryocytes. Blood 2006; 108:3360-3362.
    • (2006) Blood , vol.108 , pp. 3360-3362
    • Pastos, K.M.1    Slayton, W.B.2    Rimsza, L.M.3
  • 42
    • 0033840342 scopus 로고    scopus 로고
    • Dose-response relationship of megakaryocyte progenitors from the bone marrow of thrombocytopenic and non-thrombocytopenic neonates to recombinant thrombopoietin
    • DOI 10.1046/j.1365-2141.2000.02163.x
    • Sola MC, Du Y, Hutson AD, et al. Dose-response relationship of megakaryocyte progenitors from the bone marrow of thrombocytopenic and nonthrombocytopenic neonates to recombinant thrombopoietin. Br J Haematol 2000; 110:449-453. (Pubitemid 30646876)
    • (2000) British Journal of Haematology , vol.110 , Issue.2 , pp. 449-453
    • Sola, M.C.1    Du, Y.2    Hutson, A.D.3    Christensen, R.D.4
  • 43
    • 77954940511 scopus 로고    scopus 로고
    • Expression pattern of the thrombopoietin receptor Mpl in the murine central nervous system
    • This study demonstrated that the Tpo receptor c-mpl is present in the brain and that its distribution changes throughout development
    • Ivanova A, Wuerfel J, Zhang J, et al. Expression pattern of the thrombopoietin receptor (Mpl) in the murine central nervous system. BMC Dev Biol 2010; 10:77. This study demonstrated that the Tpo receptor (c-mpl) is present in the brain, and that its distribution changes throughout development.
    • (2010) BMC Dev. Biol. , vol.10 , pp. 77
    • Ivanova, A.1    Wuerfel, J.2    Zhang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.