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Kirpalani H, Whyte RK, Andersen C, et al. The Premature Infants in Need of Transfusion (PINT) study: a randomized, controlled trial of a restrictive (low) versus liberal (high) transfusion threshold for extremely low birth weight infants. J Pediatr 2006; 149:301-307.
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Whyte, R.K.1
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Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion
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In this study investigators evaluated neurocognitive and academic functioning in 56 school-age children who were originally enrolled in the Iowa RBC transfusion trial This study found that infants randomized as neonates to the liberal transfusion arm performed significantly worse in tests of associative verbal fluency visual memory and reading compared with infants randomized to the restrictive arm
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McCoy TE, Conrad AL, Richman LC, et al. Neurocognitive profiles of preterm infants randomly assigned to lower or higher hematocrit thresholds for transfusion. Child Neuropsychol 2011; 17:347-367. In this study, investigators evaluated neurocognitive and academic functioning in 56 school-age children who were originally enrolled in the Iowa RBC transfusion trial. This study found that infants randomized as neonates to the liberal transfusion arm performed significantly worse in tests of associative verbal fluency, visual memory, and reading compared with infants randomized to the restrictive arm.
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McCoy, T.E.1
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Long-term outcome of brain structure in premature infants: Effects of liberal vs restricted red blood cell transfusions
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This study evaluated brain volume measurements in MRI scans performed at 12 years of age in former preterm infants randomized to the liberal vs restrictive RBC transfusion arm in the Iowa trial Brain volumes were significantly smaller in infants in the liberal group particularly in girls compared with those in the restrictive group
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Nopoulos PC, Conrad AL, Bell EF, et al. Long-term outcome of brain structure in premature infants: effects of liberal vs restricted red blood cell transfusions. Arch Pediatr Adolesc Med 2011; 165:443-450. This study evaluated brain volume measurements in MRI scans performed at 12 years of age in former preterm infants randomized to the liberal vs. restrictive RBC transfusion arm in the Iowa trial. Brain volumes were significantly smaller in infants in the liberal group, particularly in girls, compared with those in the restrictive group.
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Nopoulos, P.C.1
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Mally P, Golombek SG, Mishra R, et al. Association of necrotizing enterocolitis with elective packed red blood cell transfusions in stable, growing, premature neonates. Am J Perinatol 2006; 23:451-458. (Pubitemid 46535109)
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77951690244
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This is one of the largest studies describing the development of necrotizing enterocolitis within 48 h of a RBC transfusion
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Christensen RD, Lambert DK, Henry E, et al. Is 'transfusion-associated necrotizing enterocolitis' an authentic pathogenic entity? Transfusion 2010; 50:1106-1112. This is one of the largest studies describing the development of necrotizing enterocolitis within 48 h of a RBC transfusion.
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This study proposed the hypothesis that transfusion-associated NEC could have similar pathogenesis to transfusion-associated lung injury and coined the now popular term transfusion-associated gut Injury TRAGI
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Blau J, Calo JM, Dozor D, et al. Transfusion-related acute gut injury: necrotizing enterocolitis in very low birth weight neonates after packed red blood cell transfusion. J Pediatr 2011; 158:403-409. This study proposed the hypothesis that transfusion-associated NEC could have similar pathogenesis to transfusion-associated lung injury, and coined the now popular term 'Transfusion-Associated Gut Injury' (TRAGI).
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J. Pediatr.
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Blau, J.1
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Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants
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This is one of the largest studies describing the development of necrotizing enterocolitis within 48 h of a RBC transfusion.
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Paul DA, Mackley A, Novitsky A, et al. Increased odds of necrotizing enterocolitis after transfusion of red blood cells in premature infants. Pediatrics 2011; 127:635-641. This is one of the largest studies describing the development of necrotizing enterocolitis within 48 h of a RBC transfusion.
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Pediatrics
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Paul, D.A.1
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Singh R, Visintainer PF, Frantz ID 3rd, et al. Association of necrotizing enterocolitis with anemia and packed red blood cell transfusions in preterm infants. J Perinatol 2011; 31:176-182.
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Dani C, Pratesi S, Fontanelli G, et al. Blood transfusions increase cerebral, splanchnic, and renal oxygenation in anemic preterm infants. Transfusion 2010; 50:1220-1226.
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Epub ahead of print this study is of importance because it exposed marked differences in platelet transfusion practices between US and European neonatologists and suggested that a significantly higher number of infants receive platelet transfusions in the United States compared with some European countries only on the basis of practice differences
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Cremer M, Sola-Visner M, Roll S, et al. Platelet transfusions in neonates: practices in the United States vary significantly from those in Austria, Germany, and Switzerland. Transfusion 2011. [Epub ahead of print] This study is of importance because it exposed marked differences in platelet transfusion practices between US and European neonatologists, and suggested that a significantly higher number of infants receive platelet transfusions in the United States compared with some European countries, only on the basis of practice differences.
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This study found that neonates with thrombocytopenia in general have a significantly higher mortality and risk of IVH compared with nonthrombocytopenic neonates However there was no association between the severity of the thrombocytopenia and these risks
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von Lindern JS, van den Bruele T, Lopriore E, et al. Thrombocytopenia in neonates and the risk of intraventricular hemorrhage: a retrospective cohort study. BMC Pediatrics 2011; 11:16. This study found that neonates with thrombocytopenia, in general, have a significantly higher mortality and risk of IVH compared with nonthrombocytopenic neonates. However, there was no association between the severity of the thrombocytopenia and these risks.
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