RINL, guanine nucleotide exchange factor Rab5-subfamily, is involved in the EphA8-degradation pathway with odin

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Kajiho, Hiroaki ^a   Fukushima, Shinichi ^a   Kontani, Kenji ^a   Katada, Toshiaki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; EPHRIN RECEPTOR A8; GUANINE NUCLEOTIDE EXCHANGE FACTOR; ODIN PROTEIN; RAB PROTEIN; RAS INTERACTION LIKE PROTEIN; UNCLASSIFIED DRUG; ODIN PROTEIN, HUMAN; RINL PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ALPHA CHAIN; AMINO ACID SEQUENCE; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; GENE SILENCING; HELA CELL; MOLECULAR DYNAMICS; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN QUATERNARY STRUCTURE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; ANIMAL; ARMYWORM; BIOLOGICAL MODEL; CELL CULTURE; CELL STRAIN HEK293; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MULTIGENE FAMILY; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELLS, CULTURED; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HEK293 CELLS; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; MULTIGENE FAMILY; PROTEOLYSIS; RAB GTP-BINDING PROTEINS; RAB5 GTP-BINDING PROTEINS; RECEPTOR, EPHA8; SIGNAL TRANSDUCTION; SPODOPTERA; TRANSFECTION;

EID: 84856091903     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030575     Document Type: Article

References (29)

1. Pfeffer SR, (2001) Rab GTPases: specifying and deciphering organelle identity and function. Trends Cell Biol 11: 487-491.
2. Zerial M, McBride H, (2001) Rab proteins as membrane organizers. Nat Rev Mol Cell Biol 2: 107-117.
3. Stenmark H, (2009) Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10: 513-525.
4. Carney DS, Davies BA, Horazdovsky BF, (2006) Vps9 domain-containing proteins: activators of Rab5 GTPases from yeast to neurons. Trends Cell Biol 16: 27-35.
5. Delprato A, Merithew E, Lambright DG, (2004) Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5. Cell 118: 607-617.
6. Kajiho H, Saito K, Tsujita K, Kontani K, Araki Y, et al. (2003) RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. J Cell Sci 116: 4159-4168.
7. Saito K, Murai J, Kajiho H, Kontani K, Kurosu H, et al. (2002) A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. J Biol Chem 277: 3412-3418.
8. Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF, (2001) Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. Dev Cell 1: 73-82.
9. Barbieri MA, Kong C, Chen PI, Horazdovsky BF, Stahl PD, (2003) The SRC homology 2 domain of Rin1 mediates its binding to the epidermal growth factor receptor and regulates receptor endocytosis. J Biol Chem 278: 32027-32036.
10. Deininger K, Eder M, Kramer ER, Zieglgansberger W, Dodt HU, et al. (2008) The Rab5 guanylate exchange factor Rin1 regulates endocytosis of the EphA4 receptor in mature excitatory neurons. Proc Natl Acad Sci U S A 105: 12539-12544.
11. Kimura T, Sakisaka T, Baba T, Yamada T, Takai Y, (2006) Involvement of the Ras-Ras-activated Rab5 guanine nucleotide exchange factor RIN2-Rab5 pathway in the hepatocyte growth factor-induced endocytosis of E-cadherin. J Biol Chem 281: 10598-10609.
12. Yoshikawa M, Kajiho H, Sakurai K, Minoda T, Nakagawa S, et al. (2008) Tyr-phosphorylation signals translocate RIN3, the small GTPase Rab5-GEF, to early endocytic vesicles. Biochem Biophys Res Commun 372: 168-172.
13. Kajiho H, Sakurai K, Minoda T, Yoshikawa M, Nakagawa S, et al. Characterization of RIN3 as a guanine-nucleotide exchange factor for the Rab5-subfamily GTPase Rab31. J Biol Chem.
14. Woller B, Luiskandl S, Popovic M, Prieler BE, Ikonge G, et al. (2011) Rin-like, a novel regulator of endocytosis, acts as guanine nucleotide exchange factor for Rab5a and Rab22. Biochim Biophys Acta 1813: 1198-1210.
15. Uhlik MT, Temple B, Bencharit S, Kimple AJ, Siderovski DP, et al. (2005) Structural and evolutionary division of phosphotyrosine binding (PTB) domains. J Mol Biol 345: 1-20.
16. Emaduddin M, Edelmann MJ, Kessler BM, Feller SM, (2008) Odin (ANKS1A) is a Src family kinase target in colorectal cancer cells. Cell Commun Signal 6: 7.
17. Shin J, Gu C, Park E, Park S, (2007) Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function. Mol Cell Biol 27: 8113-8126.
18. Kim J, Lee H, Kim Y, Yoo S, Park E, et al. (2010) The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptors. Mol Cell Biol 30: 1582-1592.
19. Hama H, Tall GG, Horazdovsky BF, (1999) Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. J Biol Chem 274: 15284-15291.
20. Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, et al. (1997) A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 90: 1149-1159.
21. Otomo A, Hadano S, Okada T, Mizumura H, Kunita R, et al. (2003) ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics. Hum Mol Genet 12: 1671-1687.
22. Sato M, Sato K, Fonarev P, Huang CJ, Liou W, et al. (2005) Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit. Nat Cell Biol 7: 559-569.
23. Zhang X, He X, Fu XY, Chang Z, (2006) Varp is a Rab21 guanine nucleotide exchange factor and regulates endosome dynamics. J Cell Sci 119: 1053-1062.
24. Barbieri MA, Roberts RL, Gumusboga A, Highfield H, Alvarez-Dominguez C, et al. (2000) Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a. J Cell Biol 151: 539-550.
25. Mesa R, Magadan J, Barbieri A, Lopez C, Stahl PD, et al. (2005) Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus. Exp Cell Res 304: 339-353.
26. Weigert R, Yeung AC, Li J, Donaldson JG, (2004) Rab22a regulates the recycling of membrane proteins internalized independently of clathrin. Mol Biol Cell 15: 3758-3770.
27. Kauppi M, Simonsen A, Bremnes B, Vieira A, Callaghan J, et al. (2002) The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking. J Cell Sci 115: 899-911.
28. Simonsen A, Lippe R, Christoforidis S, Gaullier JM, Brech A, et al. (1998) EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394: 494-498.
29. Saito K, Kajiho H, Araki Y, Kurosu H, Kontani K, et al. (2005) Purification and analysis of RIN family-novel Rab5 GEFs. Methods Enzymol 403: 276-283.