Identification of phosphotyrosine binding domain-containing proteins as novel downstream targets of the EphA8 signaling function

Molecular and Cellular Biology

Volumn 27, Issue 23, 2007, Pages 8113-8126

  Shin, Jongdae ^a   Gu, Changkyu ^a   Park, Eunjeong ^a   Park, Soochul ^a  

^a Sookmyung Women's University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; COMPLEMENTARY DNA; EPHRIN RECEPTOR A8; PHOSPHOTYROSINE; PROTEIN ANKS; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BRAIN TISSUE; CELL MEMBRANE; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN; CARRIER PROTEINS; CELL LINE; CELL MOVEMENT; EPHRIN-A5; FETUS; GENE LIBRARY; HUMANS; LIGANDS; MICE; NEURITES; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTOR, EPHA8; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES;

MAMMALIA;

EID: 36849014759     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.00794-07     Document Type: Article

References (45)

1. Carter, N., T. Nakamoto, H. Hirai, and T. Hunter. 2002. EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas). Nat. Cell Biol. 4:565-573.
2. Chen, Z. Y., C. Sun, K. Reuhl, A. Bergemann, M. Henkemeyer, and R. Zhou. 2004. Abnormal hippocampal axon bundling in EphB receptor mutant mice. J. Neurosci. 24:2366-2374.
3. Choi, S., and S. Park. 1999. Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. Oncogene 18:5413-5422.
4. Dail, M., M. Richter, P. Godement, and E. B. Pasquale. 2006. Eph receptors inactivate R-Ras through different mechanisms to achieve cell repulsion. J. Cell Sci. 119:1244-1254.
5. Elowe, S., S. J. Holland, S. Kulkarni, and T. Pawson. 2001. Downregulation of the Ras-mitogen-activated protein kinase pathway by the EphB2 receptor tyrosine kinase is required for ephrin-induced neurite retraction. Mol. Cell. Biol. 21:7429-7441.
6. Foo, S. S., C. J. Turner, S. Adams, A. Compagni, D. Aubyn, N. Kogata, P. Lindblom, M. Shani, D. Zicha, and R. H. Adams. 2006. Ephrin-B2 controls cell motility and adhesion during blood-vessel-wall assembly. Cell 124:161-173.
7. Ghersi, E., C. Noviello, and L. D'Adamio. 2004. Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner. J. Biol. Chem. 279:49105-49112.
8. Gu, C., and S. Park. 2001. The EphA8 receptor regulates integrin activity through p110gamma phosphatidylinositol-3 kinase in a tyrosine kinase activity-independent manner. Mol. Cell. Biol. 21:4579-4597.
9. Gu, C., and S. Park. 2003. The p110 gamma PI-3 kinase is required for EphA8-stimulated cell migration. FEBS Lett. 540:65-70.
10. Gu, C., S. Shim, J. Shin, J. Kim, J. Park, K. Han, and S. Park. 2005. The EphA8 receptor induces sustained MAP kinase activation to promote neurite outgrowth in neuronal cells. Oncogene 24:4243-4256.
11. Hattori, M., M. Osterfield, and J. G. Flanagan. 2000. Regulated cleavage of a contact-mediated axon repellent. Science 289:1360-1365.
12. Holmberg, J., D. L. Clarke, and J. Frisen. 2000. Regulation of repulsion versus adhesion by different splice forms of an Eph receptor. Nature 408:203-206.
13. Hunter, S. G., G. Zhuang, D. Brantley-Sieders, W. Swat, C. W. Cowan, and J. Chen. 2006. Essential role of Vav family guanine nucleotide exchange factors in EphA receptor-mediated angiogenesis. Mol. Cell. Biol. 26:4830-4842.
14. Huynh-Do, U., E. Stein, A. A. Lane, H. Liu, D. P. Cerretti, and T. O. Daniel. 1999. Surface densities of ephrin-B1 determine EphB1-coupled activation of cell attachment through alphavbeta3 and alpha5beta1 integrins. EMBO J. 18:2165-2173.
15. Irie, F., and Y. Yamaguchi. 2002. EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP. Nat. Neurosci. 5:1117-1128.
16. Janes, P. W., N. Saha, W. A. Barton, M. W. Kolev, S. H. Wimmer-Kleikamp, E. Nievergall, C. P. Blobel, J. P. Himanen, M. Lackmann, and D. B. Nikolov. 2005. Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in trans. Cell 123:291-304.
17. Klein, R. 2004. Eph/ephrin signaling in morphogenesis, neural development and plasticity. Curr. Opin. Cell Biol. 16:580-589.
18. Knoll, B., K. Zarbalis, W. Wurst, and U. Drescher. 2001. A role for the EphA family in the topographic targeting of vomeronasal axons. Development 128:895-906.
19. Knoll, B., and U. Drescher. 2004. Src family kinases are involved in EphA receptor-mediated retinal axon guidance. J. Neurosci. 24:6248-6257.
20. Marston, D. J., S. Dickinson, and C. D. Nobes. 2003. Rac-dependent transendocytosis of ephrinBs regulates Eph-ephrin contact repulsion. Nat. Cell Biol. 5:879-888.
21. Matsuoka, H., H. Obama, M. L. Kelly, T. Matsui, and M. Nakamoto. 2005. Biphasic functions of the kinase-defective Ephb6 receptor in cell adhesion and migration. J. Biol. Chem. 280:29355-29363.
22. McLaughlin, T., and D. O'Leary. 2005. Molecular gradients and development of retinotopic maps. Annu. Rev. Neurosci. 28:327-355.
23. Miao, H., E. Burnett, M. Kinch, E. Simon, and B. Wang. 2000. Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation. Nat. Cell Biol. 2:62-69.
24. Miao, H., B. Wei, D. M. Peehl, Q. Li, T. Alexandrou, J. Schelling, J. Rhim, J. Sedor, E. Burnett, and B. Wang. 2001. Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathway. Nat. Cell Biol. 3:527-530.
25. Miao, H., K. Strebhardt, E. B. Pasquale, T. Shen, J. Guan, and B. Wang. 2005. Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase: role of Rho family small GTPases. J. Biol. Chem. 280:923-932.
26. Murai, K., and E. B. Pasquale. 2005. New exchanges in Eph-dependent growth cone dynamics. Neuron 46:161-163.
27. Niethammer, M., E. Kim, and M. Sheng. 1996. Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J. Neurosci. 16:2157-2163.
28. Pandey, A., B. Blagoev, I. Kratchmarova, M. Fernandez, M. Nielsen, T. Z. Kristiansen, O. Ohara, A. V. Podtelejnikov, S. Roche, H. F. Lodish, and M. Mann. 2002. Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases. Oncogene 21:8029-8036.
29. Park, S., J. Frisen, and M. Barbacid. 1997. Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. EMBO J. 16:3106-3114.
30. Parri, M., F. Buricchi, M. L. Taddei, E. Giannoni, G. Raugei, G. Ramponi, and P. Chiarugi. 2005. EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase. J. Biol. Chem. 280:34008-34018.
31. Pasquale, E. B. 2005. Eph receptor signalling casts a wide net on cell behaviour. Nat. Rev. Mol. Cell. Biol. 6:462-475.
32. Penzes, P., A. Beeser, J. Chernoff, M. R. Schiller, B. A. Eipper, R. E. Mains, and R. L. Huganir. 2003. Rapid induction of dendritic spine morphogenesis by trans-synaptic ephrinB-EphB receptor activation of the Rho-GEF kalirin. Neuron 37:263-274.
33. Poliakov, A., M. Cotrina, and D. G. Wilkinson. 2004. Diverse roles of Eph receptors and ephrins in the regulation of cell migration and tissue assembly. Dev. Cell 7:465-480.
34. Pratt, R. L., and M. S. Kinch. 2002. Activation of the EphA2 tyrosine kinase stimulates the MAP/ERK kinase signaling cascade. Oncogene 21:7690-7699.
35. Sahin, M., P. L. Greer, M. Z. Lin, H. Poucher, J. Eberhart, S. Schmidt, T. M. Wright, S. M. Shamah, S. O'Connell, C. W. Cowan, L. Hu, J. L. Goldberg, A. Debant, G. Corfas, C. E. Krull, and M. E. Greenberg. 2005. Eph-dependent tyrosine phosphorylation of ephexin1 modulates growth cone collapse. Neuron 46:191-204.
36. Schmidt, A., and A. Hall. 2007. Guanine nucleotide exchange factors for Rho GTPases: turning on the switch. Genes Dev. 16:1587-1609.
37. Shamah, S. M., M. Z. Lin, J. L. Goldberg, S. Estrach, M. Sahin, L. Hu, M. Bazalakova, R. L. Neve, G. Corfas, A. Debant, and M. E. Greenberg. 2001. EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. Cell 105:233-244.
38. Shintani, T., M. Ihara, H. Sakuta, H. Takahashi, I. Watakabe, and M. Noda. 2006. Eph receptors are negatively controlled by protein tyrosine phosphatase receptor type O. Nat. Neurosci. 9:761-769.
39. Stein, E., A. A. Lane, D. P. Cerretti, H. O. Schoecklmann, A. D. Schroff, R. L. Van Etten, and T. O. Daniel. 1998. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes Dev. 12:667-678.
40. Tanaka, M., R. Ohashi, R. Nakamura, K. Shinmura, T. Kamo, R. Sakai, and H. Sugimura. 2004. Tiam1 mediates neurite outgrowth induced by ephrin-B1 and EphA2. EMBO J. 23:1075-1088.
41. Uhlik, M. T., B. Temple, S. Bencharit, A. J. Kimple, D. P. Siderovski, and G. L. Johnson. 2005. Structural and evolutionary division of phosphotyrosine binding (PTB) domains. J. Mol. Biol. 345:1-20.
42. Vindis, C., D. P. Cerretti, T. O. Daniel, and U. Huynh-Do. 2003. EphB1 recruits c-Src and p52Shc to activate MAPK/ERK and promote chemotaxis. J. Cell Biol. 162:661-671.
43. Wang, H. U., and D. J. Anderson. 1997. Eph family transmembrane ligands can mediate repulsive guidance of trunk neural crest migration and motor axon outgrowth. Neuron 18:383-396.
44. Zimmer, M., A. Palmer, J. Kohler, and R. Klein. 2003. EphB-ephrinB bidirectional endocytosis terminates adhesion allowing contact mediated repulsion. Nat. Cell Biol. 5:869-878.
45. Zou, J. X., B. Wang, M. S. Kalo, A. H. Zisch, E. Pasquale, and E. Ruoslahti. 1999. An Eph receptor regulates integrin activity through R-Ras. Proc. Natl. Acad. Sci. USA 96:13813-13818.