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Volumn 30, Issue 2, 2012, Pages 95-99

Concise review: Cancer stem cells: In vitro models

Author keywords

Cancer stem cells; In vitro culture; Models; Stem cell plasticity

Indexed keywords

CELL MARKER; CELL SURFACE PROTEIN; TUMOR MARKER;

EID: 84856089677     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.774     Document Type: Review
Times cited : (30)

References (59)
  • 1
    • 79952370202 scopus 로고    scopus 로고
    • The cancer stem cell: Premises, promises and challenges
    • Clevers H. The cancer stem cell: Premises, promises and challenges. Nat Med 2011;17:313-319.
    • (2011) Nat Med , vol.17 , pp. 313-319
    • Clevers, H.1
  • 2
    • 58149380742 scopus 로고    scopus 로고
    • Stem cell concepts renew cancer research
    • Dick JE. Stem cell concepts renew cancer research. Blood 2008;112: 4793-4807.
    • (2008) Blood , vol.112 , pp. 4793-4807
    • Dick, J.E.1
  • 3
    • 79953872172 scopus 로고    scopus 로고
    • Prostate cancer stem cells and their potential roles in metastasis
    • Li H, Tang DG. Prostate cancer stem cells and their potential roles in metastasis. J Surg Oncol 2011;103:558-562.
    • (2011) J Surg Oncol , vol.103 , pp. 558-562
    • Li, H.1    Tang, D.G.2
  • 4
    • 79955681163 scopus 로고    scopus 로고
    • The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse
    • Merlos-Suárez A, Barriga FM, Jung P et al. The intestinal stem cell signature identifies colorectal cancer stem cells and predicts disease relapse. Cell Stem Cell 2011;8:511-524.
    • (2011) Cell Stem Cell , vol.8 , pp. 511-524
    • Merlos-Suárez, A.1    Barriga, F.M.2    Jung, P.3
  • 5
    • 79959238013 scopus 로고    scopus 로고
    • Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
    • Medema JP, Vermeulen L. Microenvironmental regulation of stem cells in intestinal homeostasis and cancer. Nature 2011;474:318-326.
    • (2011) Nature , vol.474 , pp. 318-326
    • Medema, J.P.1    Vermeulen, L.2
  • 6
    • 79952392467 scopus 로고    scopus 로고
    • Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression
    • Bissell MJ, Hines WC. Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med 2011;17:320-329.
    • (2011) Nat Med , vol.17 , pp. 320-329
    • Bissell, M.J.1    Hines, W.C.2
  • 7
    • 12344318372 scopus 로고    scopus 로고
    • Context, tissue plasticity, and cancer: Are tumor stem cells also regulated by the microenvironment?
    • DOI 10.1016/j.ccr.2004.12.013, PII S1535610804003757
    • Bissell MJ, Labarge MA. Context, tissue plasticity, and cancer: Are tumor stem cells also regulated by the microenvironment?Cancer Cell 2005;7:17-23. (Pubitemid 40126379)
    • (2005) Cancer Cell , vol.7 , Issue.1 , pp. 17-23
    • Bissell, M.J.1    Labarge, M.A.2
  • 8
    • 78751522709 scopus 로고    scopus 로고
    • Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks
    • Liu S, Ginestier C, Ou SJ et al. Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res 2011;71:614-624.
    • (2011) Cancer Res , vol.71 , pp. 614-624
    • Liu, S.1    Ginestier, C.2    Ou, S.J.3
  • 9
    • 33750313208 scopus 로고    scopus 로고
    • Cancer stem cells - Perspectives on current status and future directions: AACR Workshop on cancer stem cells
    • Clarke MF, Dick JE, Dirks PB et al. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006;66:9339-9344.
    • (2006) Cancer Res , vol.66 , pp. 9339-9344
    • Clarke, M.F.1    Dick, J.E.2    Dirks, P.B.3
  • 10
    • 78650950098 scopus 로고    scopus 로고
    • Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/ SCID/IL2Rcc-deficient mice
    • Sarry J-E, Murphy K, Perry R et al. Human acute myelogenous leukemia stem cells are rare and heterogeneous when assayed in NOD/ SCID/IL2Rcc-deficient mice. J Clin Invest 2011;121:384-395.
    • (2011) J Clin Invest , vol.121 , pp. 384-395
    • Sarry, J.-E.1    Murphy, K.2    Perry, R.3
  • 11
    • 33847052127 scopus 로고    scopus 로고
    • Identification of pancreatic cancer stem cells
    • Li C, Heidt DG, Dalerba P et al. Identification of pancreatic cancer stem cells. Cancer Res 2007;67:1030-1037.
    • (2007) Cancer Res , vol.67 , pp. 1030-1037
    • Li, C.1    Heidt, D.G.2    Dalerba, P.3
  • 13
    • 51649111430 scopus 로고    scopus 로고
    • Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
    • Vermeulen L, Todaro M, de Sousa Mello F et al. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proc Natl Acad Sci USA 2008;105:13427-13432.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 13427-13432
    • Vermeulen, L.1    Todaro, M.2    De Sousa Mello, F.3
  • 14
    • 60549111070 scopus 로고    scopus 로고
    • Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature
    • Charafe-Jauffret E, Ginestier C, Iovino F et al. Breast cancer cell lines contain functional cancer stem cells with metastatic capacity and a distinct molecular signature. Cancer Res 2009;69:1302-1313.
    • (2009) Cancer Res , vol.69 , pp. 1302-1313
    • Charafe-Jauffret, E.1    Ginestier, C.2    Iovino, F.3
  • 16
    • 38349075007 scopus 로고    scopus 로고
    • CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells
    • Wang J, Sakariassen PÄ, Tsinkalovsky O et al. CD133 negative glioma cells form tumors in nude rats and give rise to CD133 positive cells. Int J Cancer 2008;122:761-768.
    • (2008) Int J Cancer , vol.122 , pp. 761-768
    • Wang, J.1    Sakariassen, P.Ä.2    Tsinkalovsky, O.3
  • 17
    • 66049085403 scopus 로고    scopus 로고
    • Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens
    • Pollard SM, Yoshikawa K, Clarke ID et al. Glioma stem cell lines expanded in adherent culture have tumor-specific phenotypes and are suitable for chemical and genetic screens. Cell Stem Cell 2009;4: 568-580.
    • (2009) Cell Stem Cell , vol.4 , pp. 568-580
    • Pollard, S.M.1    Yoshikawa, K.2    Clarke, I.D.3
  • 18
    • 78249250559 scopus 로고    scopus 로고
    • Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    • Quintana E, Shackleton M, Foster HR et al. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 2010;18:510-523.
    • (2010) Cancer Cell , vol.18 , pp. 510-523
    • Quintana, E.1    Shackleton, M.2    Foster, H.R.3
  • 19
    • 79955543814 scopus 로고    scopus 로고
    • Melanoma stem cells: Not rare, but well done
    • Girouard SD, Murphy GF. Melanoma stem cells: Not rare, but well done. Lab Invest 2011;91:647-664.
    • (2011) Lab Invest , vol.91 , pp. 647-664
    • Girouard, S.D.1    Murphy, G.F.2
  • 20
    • 79956351015 scopus 로고    scopus 로고
    • Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state
    • Chaffer C, Brueckmann I, Scheel C. Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci USA 2011;108:7950-7955.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 7950-7955
    • Chaffer, C.1    Brueckmann, I.2    Scheel, C.3
  • 21
    • 79952121979 scopus 로고    scopus 로고
    • Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion
    • Iliopoulos D, Hirsch H, Wang G. Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion. Proc Natl Acad Sci USA 2011;108:1397-1402.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 1397-1402
    • Iliopoulos, D.1    Hirsch, H.2    Wang, G.3
  • 22
    • 70349419698 scopus 로고    scopus 로고
    • The 'stem cell' concept: Is it holding us back?
    • Lander AD. The 'stem cell' concept: Is it holding us back?J Biol 2009;8:70.
    • (2009) J Biol , vol.8 , pp. 70
    • Lander, A.D.1
  • 23
    • 38449091379 scopus 로고    scopus 로고
    • Markers in normal and cancer stem cells
    • Stem Cells and Cancer
    • Natarajan TG, FitzGerald KT. Markers in normal and cancer stem cells. Cancer Biomark 2007;3:211-231. (Pubitemid 351492646)
    • (2007) Cancer Biomarkers , vol.3 , Issue.4-5 , pp. 211-231
    • Natarajan, T.G.1    FitzGerald, K.T.2
  • 24
    • 49749144107 scopus 로고    scopus 로고
    • The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells
    • Bidlingmaier S, Zhu X, Liu B. The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells. J Mol Med 2008;86:1025-1032.
    • (2008) J Mol Med , vol.86 , pp. 1025-1032
    • Bidlingmaier, S.1    Zhu, X.2    Liu, B.3
  • 25
    • 67349191354 scopus 로고    scopus 로고
    • Aldehyde dehydrogenase as a marker for stem cells
    • Moreb JS. Aldehyde dehydrogenase as a marker for stem cells. Curr Stem Cell Res Ther 2008;3:237-246.
    • (2008) Curr Stem Cell Res Ther , vol.3 , pp. 237-246
    • Moreb, J.S.1
  • 26
    • 60149101077 scopus 로고    scopus 로고
    • ALDH1 as a functional marker of cancer stem and progenitor cells
    • Douville J, Beaulieu R, Balicki D. ALDH1 as a functional marker of cancer stem and progenitor cells. Stem Cells Dev 2009;18:17-26.
    • (2009) Stem Cells Dev , vol.18 , pp. 17-26
    • Douville, J.1    Beaulieu, R.2    Balicki, D.3
  • 27
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of- Origin of intestinal cancer
    • Barker N, Ridgway RA, van Es JH et al. Crypt stem cells as the cells-of- origin of intestinal cancer. Nature 2009;457:608-612.
    • (2009) Nature , vol.457 , pp. 608-612
    • Barker, N.1    Ridgway, R.A.2    Van Es, J.H.3
  • 28
    • 58749114163 scopus 로고    scopus 로고
    • Normal stem cells in cancer prone epithelial tissues
    • Phesse TJ, Clarke AR. Normal stem cells in cancer prone epithelial tissues. Br J Cancer 2009;100:221-227.
    • (2009) Br J Cancer , vol.100 , pp. 221-227
    • Phesse, T.J.1    Clarke, A.R.2
  • 29
    • 33745600820 scopus 로고    scopus 로고
    • Asymmetric and symmetric stem-cell divisions in development and cancer
    • DOI 10.1038/nature04956, PII N04956
    • Morrison SJ, Kimble J. Asymmetric and symmetric stem-cell divisions in development and cancer. Nature 2006;441:1068-1074. (Pubitemid 43990718)
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1068-1074
    • Morrison, S.J.1    Kimble, J.2
  • 30
    • 72549092813 scopus 로고    scopus 로고
    • Dividing cellular asymmetry: Asymmetric cell division and its implications for stem cells and cancer
    • Neumuller RA, Knoblich JA. Dividing cellular asymmetry: Asymmetric cell division and its implications for stem cells and cancer. Genes Dev 2009;23:2675-2699.
    • (2009) Genes Dev , vol.23 , pp. 2675-2699
    • Neumuller, R.A.1    Knoblich, J.A.2
  • 31
    • 78650448449 scopus 로고    scopus 로고
    • Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice
    • Lombardo Y, Scopelliti A, Cammareri P et al. Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice. Gastroenterology 2011;140:297-309.
    • (2011) Gastroenterology , vol.140 , pp. 297-309
    • Lombardo, Y.1    Scopelliti, A.2    Cammareri, P.3
  • 32
    • 70350244836 scopus 로고    scopus 로고
    • Retinoid signaling regulates breast cancer stem cell differentiation
    • Ginestier C, Wicinski J, Cervera N et al. Retinoid signaling regulates breast cancer stem cell differentiation. Cell Cycle 2009;8:3297-3302.
    • (2009) Cell Cycle , vol.8 , pp. 3297-3302
    • Ginestier, C.1    Wicinski, J.2    Cervera, N.3
  • 33
    • 35148900228 scopus 로고    scopus 로고
    • The fuzzy math of solid tumor stem cells: A perspective
    • DOI 10.1158/0008-5472.CAN-07-1971
    • Kern SE, Shibata D. The fuzzy math of solid tumor stem cells: A perspective. Cancer Res 2007;67:8985-8988. (Pubitemid 47535878)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 8985-8988
    • Kern, S.E.1    Shibata, D.2
  • 34
    • 48949119465 scopus 로고    scopus 로고
    • Cancer stem cell heterogeneity in hereditary breast cancer
    • Wicha MS. Cancer stem cell heterogeneity in hereditary breast cancer. Breast Cancer Res 2008;10:105.
    • (2008) Breast Cancer Res , vol.10 , pp. 105
    • Wicha, M.S.1
  • 35
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodríguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nature 2011;17:330-339.
    • (2011) Nature , vol.17 , pp. 330-339
    • Rodríguez-Paredes, M.1    Esteller, M.2
  • 36
    • 78650731409 scopus 로고    scopus 로고
    • The therapeutic implications of plasticity of the cancer stem cell phenotype
    • Leder K, Holland EC, Michor F. The therapeutic implications of plasticity of the cancer stem cell phenotype. PLoS ONE 2010;5:e14366.
    • (2010) PLoS ONE , vol.5
    • Leder, K.1    Holland, E.C.2    Michor, F.3
  • 37
    • 77950863856 scopus 로고    scopus 로고
    • Expansion of CD133+ colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery
    • Fang DD, Kim YJ, Lee CN et al. Expansion of CD133+ colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery. Br J Cancer 2010;102:1265-1275.
    • (2010) Br J Cancer , vol.102 , pp. 1265-1275
    • Fang, D.D.1    Kim, Y.J.2    Lee, C.N.3
  • 38
    • 77649257052 scopus 로고    scopus 로고
    • Cancer stem cells from colorectal cancer-derived cell lines
    • Yeung TM, Gandhi SC, Wilding JL et al. Cancer stem cells from colorectal cancer-derived cell lines. Proc Natl Acad Sci USA 2010;107:3722-3727.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 3722-3727
    • Yeung, T.M.1    Gandhi, S.C.2    Wilding, J.L.3
  • 39
    • 40949088678 scopus 로고    scopus 로고
    • PC3 human prostate carcinoma cell holoclones contain self-renewing tumor-initiating cells
    • DOI 10.1158/0008-5472.CAN-07-5878
    • Li H, Chen X, Calhoun-Davis T et al. PC3 human prostate carcinoma cell holoclones contain self-renewing tumor-initiating cells. Cancer Res 2008;68:1820-1825. (Pubitemid 351416567)
    • (2008) Cancer Research , vol.68 , Issue.6 , pp. 1820-1825
    • Li, H.1    Chen, X.2    Calhoun-Davis, T.3    Claypool, K.4    Tang, D.G.5
  • 42
    • 42949156163 scopus 로고    scopus 로고
    • Isolation and establishment of human tumor stem cells
    • Roberts PE. Isolation and establishment of human tumor stem cells. Methods Cell Biol 2008;86:325-342.
    • (2008) Methods Cell Biol , vol.86 , pp. 325-342
    • Roberts, P.E.1
  • 45
    • 0023213621 scopus 로고
    • Extended culture of mouse embryo cells without senescence: Inhibition by serum
    • Loo DT, Fuquay JI, Rawson CL, Barnes DW. Extended culture of mouse embryo cells without senescence: Inhibition by serum. Science 1987;236:200-202. (Pubitemid 17061040)
    • (1987) Science , vol.236 , Issue.4798 , pp. 200-202
    • Loo, D.T.1    Fuquay, J.I.2    Rawson, C.L.3    Barnes, D.W.4
  • 47
    • 34248140257 scopus 로고    scopus 로고
    • Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens
    • DOI 10.1158/0008-5472.CAN-06-4429
    • Miki J, Furusato B, Li H et al. Identification of putative stem cell markers, CD133 And CXCR4, in hTERT-immortalized primary nonmalignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens. Cancer Res 2007; 67:3153-3161. (Pubitemid 46724852)
    • (2007) Cancer Research , vol.67 , Issue.7 , pp. 3153-3161
    • Miki, J.1    Furusato, B.2    Li, H.3    Gu, Y.4    Takahashi, H.5    Egawa, S.6    Sesterhenn, I.A.7    McLeod, D.G.8    Srivastava, S.9    Rhim, J.S.10
  • 48
    • 79959735149 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition by TGFβ-1 induction increases stemness characteristics in primary non small cell lung cancer cell line
    • Pirozzi G, Tirino V, Camerlingo R et al. Epithelial to mesenchymal transition by TGFβ-1 induction increases stemness characteristics in primary non small cell lung cancer cell line. PLoS ONE 2011;6: e21548.
    • (2011) PLoS ONE , vol.6
    • Pirozzi, G.1    Tirino, V.2    Camerlingo, R.3
  • 49
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits. Nat Rev Cancer 2009;9:265-273.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 50
    • 42949084145 scopus 로고    scopus 로고
    • Culture of pluripotent neural epithelial progenitor cells from e9 rat embryo
    • Li R, Mather JP. Culture of pluripotent neural epithelial progenitor cells from e9 rat embryo. Methods Cell Biol 2008;86:227-240.
    • (2008) Methods Cell Biol , vol.86 , pp. 227-240
    • Li, R.1    Mather, J.P.2
  • 51
    • 33749182067 scopus 로고    scopus 로고
    • The phenotypes of pluripotent human hepatic progenitors
    • DOI 10.1634/stemcells.2006-0036
    • Schmelzer E, Wauthier E, Reid LM. The phenotypes of pluripotent human hepatic progenitors. Stem Cells 2006;24:1852-1858. (Pubitemid 44474161)
    • (2006) Stem Cells , vol.24 , Issue.8 , pp. 1852-1858
    • Schmelzer, E.1    Wauthier, E.2    Reid, L.M.3
  • 52
    • 77955268969 scopus 로고    scopus 로고
    • New models for cancer research: Human cancer stem cell xenografts
    • Baiocchi M, Biffoni M, Ricci-Vitiani L et al. New models for cancer research: Human cancer stem cell xenografts. Curr Opin Pharmacol 2010;10:380-384.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 380-384
    • Baiocchi, M.1    Biffoni, M.2    Ricci-Vitiani, L.3
  • 53
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • Gupta PB, Onder TT, Jiang G et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 2009;138:1-15.
    • (2009) Cell , vol.138 , pp. 1-15
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3
  • 54
    • 84856113427 scopus 로고    scopus 로고
    • A stem cell-based platform for the discovery and development of anti-tumor therapeutic antibodies to novel targets
    • Little M, ed. Cambridge University Press: NY, NY
    • Mather JP, Fieger C, Liang T et al. A stem cell-based platform for the discovery and development of anti-tumor therapeutic antibodies to novel targets. In: Little M, ed. Recombinant Antibodies for Immunotherapy, Cambridge University Press: NY, NY, 2009;313-335.
    • (2009) Recombinant Antibodies for Immunotherapy , pp. 313-335
    • Mather, J.P.1    Fieger, C.2    Liang, T.3
  • 55
    • 80051967505 scopus 로고    scopus 로고
    • Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells
    • Gupta PB, Fillmore CM, Jiang G et al. Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. Cell 2011;146:633-644.
    • (2011) Cell , vol.146 , pp. 633-644
    • Gupta, P.B.1    Fillmore, C.M.2    Jiang, G.3
  • 56
    • 33846239456 scopus 로고    scopus 로고
    • Beyond tumorigenesis: Cancer stem cells in metastasis
    • DOI 10.1038/sj.cr.7310118, PII 7310118
    • Li F, Tiede B, Massagué J, Kang Y. Beyond tumorigenesis: Cancer stem cells in metastasis. Cell Res 2007;17:3-14. (Pubitemid 46096419)
    • (2007) Cell Research , vol.17 , Issue.1 , pp. 3-14
    • Li, F.1    Tiede, B.2    Massague, J.3    Kang, Y.4
  • 57
    • 79953676315 scopus 로고    scopus 로고
    • The role of colorectal cancer stem cells in metastatic disease and therapeutic response
    • Anderson EC, Hessman C, Levin TG et al. The role of colorectal cancer stem cells in metastatic disease and therapeutic response. Cancers 2011;3:319-339.
    • (2011) Cancers , vol.3 , pp. 319-339
    • Anderson, E.C.1    Hessman, C.2    Levin, T.G.3
  • 58
    • 79959736408 scopus 로고    scopus 로고
    • Colon cancer stem cells: Bench-to-Bedside - New therapeutical approaches in clinical oncology for disease breakdown
    • Di Franco S, Mancuso P, Benfante A et al. Colon cancer stem cells: Bench-to-Bedside - New therapeutical approaches in clinical oncology for disease breakdown. Cancers 2011;3:1957-1974.
    • (2011) Cancers , vol.3 , pp. 1957-1974
    • Di Franco, S.1    Mancuso, P.2    Benfante, A.3
  • 59
    • 79958103914 scopus 로고    scopus 로고
    • Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors
    • Sottoriva A, Vermeulen L, Tavaré S. Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors. PLoS Comput Biol 2011;7:e1001132.
    • (2011) PLoS Comput Biol , vol.7
    • Sottoriva, A.1    Vermeulen, L.2    Tavaré, S.3


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