Analysis of clonality and HPV infection in benign, hyperplastic, premalignant, and malignant lesions of the vulvar mucosa

American Journal of Clinical Pathology

Volumn 122, Issue 2, 2004, Pages 266-274

  Ueda, Yutaka ^a   Enomoto, Takayuki ^a   Miyatake, Takashi ^a   Shroyer, Kenneth R ^b   Yoshizaki, Tatsuo ^a   Kanao, Hiroyuki ^a   Ueno, Yuko ^a   Sun, Hongbo ^a   Nakashima, Ryuichi ^a   Yoshino, Kiyoshi ^a   Kimura, Toshihiro ^a   Haba, Tomoko ^c   Wakasa, Kenichi ^c   Murata, Yuji ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b UNIVERSITY OF COLORADO   (United States)

^c OSAKA CITY UNIVERSITY HOSPITAL   (Japan)

Author keywords

Clonality; HPV; Human papillomavirus; Integration; Neoplastic; Nonneoplastic; Premalignant; Vulva

Indexed keywords

ARTICLE; BASAL CELL CARCINOMA; CARCINOGENESIS; CLONAL VARIATION; FEMALE; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; HYPERPLASIA; INVASIVE CARCINOMA; LICHEN SCLEROSUS ET ATROPHICUS; MALIGNANT NEOPLASTIC DISEASE; MELANOMA; NONHUMAN; PAGET SKIN DISEASE; PRECANCER; PRIORITY JOURNAL; RISK ASSESSMENT; SQUAMOUS CELL CARCINOMA; SQUAMOUS CELL HYPERPLASIA; VIRUS INFECTION; VULVA CANCER; VULVA CARCINOMA; VULVA DISEASE; VULVA MUCOSA HYPERPLASIA; VULVAR INTRAEPITHELIAL NEOPLASIA; WART VIRUS; X CHROMOSOME INACTIVATION;

EID: 3242759704     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1309/65MKPQT3E2BDM67E     Document Type: Article

References (46)

1. Hacker NF. Vulvar cancer. In: Berek JS, ed. Novak's Gynecology. 12th ed. Baltimore, MD: Williams & Wilkins; 1996:1231-1259.
2. Wilkinson EJ. Premalignant and malignant tumors of the vulva. In: Kurman RJ, ed. Blaustein's Pathology of the Female Genital Tract. 4th ed. New York, NY: Springer-Verlag; 1994:87-129.
3. Rouzier R, Morice P, Haie-Meder C, et al. Prognostic significance of epithelial disorders adjacent to invasive vulvar carcinomas. Gynecol Oncol. 2001;81:414-419.
4. Gompel C, Silverberg SG. The vulva. In: Pathology in Gynecology and Obstetrics. 4th ed. Philadelphia, PA: Lippincott; 1994:1-45.
5. Ridley CM, Frankman O, Jones ISC, et al. New nomenclature for vulvar disease: report of the Committee on Terminology of the International Society for the Study of Vulvar Disease. J Reprod Med. 1990;35:483-484.
6. Jones RW, Park JS, McLean MR, et al. Human papillomavirus in women with vulvar intraepithelial neoplasia 111. J Reprod Med. 1990;35:1124-1126.
7. Chafe W, Richards A, Morgan L, et al. Unrecognized invasive carcinoma in vulvar intraepithelial neoplasia (VIN). Gynecol Oncol. 1988;31:154-165.
8. Jones RW, McLean MR. Carcinoma in situ of the vulva: a review of 31 treated and 5 untreated cases. Obstet Gynecol. 1986;68:499-503.
9. Buscema J, Woodruff JD, Parmley TH, et al. Carcinoma in situ of the vulva. Obstet Gynecol. 1980;55:225-230.
10. Jones RW, Roman D. Vulvar intraepithelial neoplasia III: a clinical study of the outcome in 113 cases with relation to the later development of invasive vulvar carcinoma. Obstet Gynecol. 1994;84:741-745.
11. Curtin JP, Rubin SC, Jones WB, et al. Paget's disease of the vulva. Gynecol Oncol. 1990;39:374-377.
12. Wilkinson EJ. Benign diseases of the vulva. In: Kurman RJ, ed. Blaustein's Pathology of the Female Genital Tract. 4th ed. New York, NY: Springer-Verlag; 1994:1-86.
13. Micheletti L, Borgno G, Barbero M, et al. Cellular atypia in vulvar dystrophies. J Reprod Med. 1988;33:539-541
14. Hart WR, Norris HJ, Helwig EB, et al. Relation of lichen sclerosus et atrophicus of the vulva to development of carcinoma. Obstet Gynecol. 1976;45:369-377.
15. Wallace HJ. Lichen sclerosus et atrophicus. Trans St Johns Hosp Dermatol Soc. 1971;57:9-30.
16. Meffert JJ, Davis BM, Grimwood RE. Lichen sclerosus. J Am Acad Dermatol. 1995;32:393-416.
17. Lyon ME. X-chromosome inactivation as a system of gene dosage compensation to regulate gene expression. Prog Nucleic Acid Res Mol Biol. 1989;36:119-130.
18. Vogelstein B, Fearon ER, Hamilton SR, et al. Use of restriction fragment length polymorphism to determine the clonal origin of human tumors. Science. 1985;227:642-645.
19. Das BC, Sharma JK, Gopalakrishna V, et al. Analysis by polymerase chain reaction of the physical state of human papillomavirus type 16 DNA in cervical preneoplastic and neoplastic lesions. J Gen Virol. 1992;73:2327-2336.
20. Kalantari M, Karlsen F, Kristensen G, et al. Disruption of the El and E2 reading frames of HPV16 in cervical carcinoma is associated with poor prognosis. Int J Gynecol Pathol. 1998;17:146-153.
21. zur Hausen H. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology. 1991;184:9-13.
22. Nagao S, Yoshinouchi M, Miyagi Y, et al. Rapid and sensitive detection of physical status of human papillomavirus type 16 DNA by quantitative real-time PCR. J Clin Microbiol. 2002;40:863-867.
23. Peitsaro P, Johansson B, Syrjanen S. Integrated human papillomavirus type 16 is frequently found in cervical cancer precursors as demonstrated by a novel quantitative real-time PCR technique. J Clin Microbiol. 2002;40:886-891.
24. Ueda Y, Enomoto T, Miyatake T, et al. Monoclonal expansion with integration of high-risk type human papillomaviruses is an initial step for cervical carcinogenesis: association of clonal status and human papillomavirus infection with clinical outcome in cervical intraepithelial neoplasia. Lab Invest. 2003;83:1517-1527.
25. Enomoto T, Fujita M, Inoue M, et al. Analysis of clonality by amplification of short tandem repeats: carcinomas of the female reproductive tract. Diagn Mol Pathol. 1994;3:292-297.
26. Allen RC, Zoghbi HY, Moseley AB, et al. Methylation of Hpa11 and Hha1 sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am J Hum Genet. 1992;51:1229-1239.
27. Fujinaga Y, Shimada M, Okazawa K, et al. Simultaneous detection and typing of genital human papillomavirus DNA using the polymerase chain reaction. J Gen Virol. 1991;72:1039-1044.
28. Park JS, Hwang ES, Park SN, et al. Physical status and expression of HPV genes in cervical cancers. Gynecol Oncol. 1997;65:121-129.
29. Yutsudo M, Okamoto Y, Hakura A. Functional dissociation of transforming genes of human papillomavirus type 16. Virology. 1988;166:594-597.
30. Rodke G, Friedrich EG Jr, Wilkinson EJ. Malignant potential of mixed vulvar dystrophy. J Reprod Med. 1988;33:545-550.
31. Neill SM, Lessana-Leibowitch M, Pelisse M, et al. Lichen sclerosus, invasive squamous cell carcinoma, and human papillomavirus [letter]. Am J Obstet Gynecol. 1990;162:1633-1634.
32. Gomez Rueda N, Garcia A, Vighi S, et al. Epithelial alterations adjacent to invasive squamous carcinoma of the vulva. J Reprod Med. 1994;39:526-530.
33. Borgno G, Micheletti L, Barbero M, et al. Epithelial alterations adjacent to 111 vulvar carcinomas. J Reprod Med. 1988;33:500-502.
34. Barbero M, Micheletti L, Preti M, et al. Biologic behavior of vulvar intraepithelial neoplasia. J Reprod Med. 1993;38:108-112.
35. McNally OM, Mulvany NJ, Pagano R, et al. V1N 3: a clinicopathological review. Int J Gynecol Cancer. 2002;12:490-495.
36. Noda K, Yajima A, Higashiiwai H, et al. Histopathologic criterion of dysplasia of the uterine cervix and its biological nature. Acta Cytol. 1976;20:224-228.
37. Tate JE, Mutter GL, Boynton KA, et al. Monoclonal origin of vulvar intraepithelial neoplasia and some vulvar hyperplasia. Am J Pathol. 1997;150:315-322.
38. Goldblum JR, Hart WR. Vulvar Paget's disease: a clinicopathologic and immunohistochemical study of 19 cases. Am J Surg Pathol. 1997;21:1178-1187.
39. Gasco M, Sullivan A, Repellin C, et al. Coincident inactivation of 14-3-3sigma and p16INK4a is an early event in vulvar squamous neoplasia. Oncogene. 2002;21:1876-1881.
40. Oyama N, Chan I, Neil SM, et al. Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Lancet. 2003;362:118-123.
41. Scurry J, Whitehead J, Healey M. Histology of lichen sclerosus varies according to site and proximity to carcinoma. Am J Dermatopathol. 2001;23:413-418.
42. Crum CP, McLachlin CM, Tate JE, et al. Pathobiology of vulvar squamous neoplasia. Curr Opin Obstet Gynecol. 1997;9:63-69.
43. Rolfe KJ, Eva LJ, Maclean AB, et al. Cell cycle proteins as molecular markers of malignant change in vulvar lichen sclerosus. Int J Gynecol Cancer. 2001;11:113-118.
44. Lin MC, Mutter GL, Trivijisilp P, et al. Patterns of allelic loss (LOH) in vulvar squamous and adjacent noninvasive epithelia. Am J Pathol. 1998;152:1313-1318.
45. Pinto AP, Lin MC, Sheets EE, et al. Allelic imbalance in lichen sclerosus, hyperplasia, and intraepithelial neoplasia of the vulva. Gynecol Oncol. 2000;77:171-176.
46. Carlson JA, Ambros R, Malfetano J, et al. Vulvar lichen sclerosus and squamous cell carcinoma. Hum Pathol. 1998;29:932-948.