DNA demethylase is expressed in ovarian cancers and the expression correlates with demethylation of CpG sites in the promoter region of c-erbB-2 and survivin genes

Cancer Letters

Volumn 169, Issue 2, 2001, Pages 155-164

  Hattori, M ^a   Sakamoto, H ^a   Satoh, K ^a   Yamamoto, T ^a  

^a NIHON UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

C erbB 2; DNA demethylase; Ovarian cancer; Survivin

Indexed keywords

DNA;

ADOLESCENT; ADULT; AGED; ARTICLE; CANCER STAGING; CELL LINE; CONTROLLED STUDY; CPG ISLAND; DEMETHYLATION; EXON; FEMALE; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN TISSUE; ONCOGENE C ERB; OVARY CARCINOMA; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RECEPTOR UPREGULATION;

ADOLESCENT; ADULT; AGED; CPG ISLANDS; DNA; DNA METHYLATION; DNA, COMPLEMENTARY; EXONS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MICROTUBULE-ASSOCIATED PROTEINS; MIDDLE AGED; NEOPLASM PROTEINS; OVARIAN NEOPLASMS; OVARY; OXIDOREDUCTASES, O-DEMETHYLATING; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); PROTEINS; RECEPTOR, ERBB-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TEMPERATURE;

MARTES PENNANTI;

EID: 0035964487     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00499-2     Document Type: Article

References (19)

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4. Identification and characterization of a family of mammalian methyl-CpG binding proteins
5. Expression and localization of oxytocin receptor gene in human uterine endometrium in relation to the menstrual cycle
6. Identification of a novel promoter and exons of the c-ERBB-2 gene
7. Molecular cloning of effector cell protease receptor-1, a novel cell surface receptor for the protease factor Xa
8. DNA demethylase is a processive enzyme
9. Hypermethylation in the retinoblastoma gene is associated with unilateral, sporadic retinoblastoma
10. Cytosine methylation transforms an E2F site in the retinoblastoma gene promoter into a binding site for the general repressor methylcytosine-binding protein 2 (MeCP2)
11. Methylation of estrogen and progesterone receptor gene 5′ CpG islands correlates with lack of estrogen and progesterone receptor gene expression in breast tumors
12. Examination of the DNA methylation properties in nontumorigenic and tumorigenic breast epithelial cell lines
13. Methylation of the androgen receptor promoter CpG island is associated with loss of androgen receptor expression in prostate cancer cells
14. Characterization of the promoter region of the human c-erbB-2 protooncogene
15. Overexpression of HER-2/neu is associated with poor survival in advanced epithelial ovarian cancer
16. Gene expression in primary, metastatic and recurrent lesions of endometrial cancer
17. Expression of the antiapoptosis gene, survivin, predicts death from recurrent colorectal carcinoma
18. High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma
19. Transcriptional analysis of human survivin gene expression