A novel activity from an old compound: Manzamine A reduces the metastatic potential of AsPC-1 pancreatic cancer cells and sensitizes them to TRAIL-induced apoptosis

Investigational New Drugs

Volumn 29, Issue 5, 2011, Pages 777-785

  Guzmán, Esther A ^a   Johnson, Jacob D ^a   Linley, Patricia A ^a   Gunasekera, Sarath E ^a   Wright, Amy E ^a  

^a FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

Drug discovery; Mechanism of action; Natural products; Pancreatic cancer

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; GLYCOGEN SYNTHASE KINASE 3BETA; MANZAMINE A; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; CARBAZOLE DERIVATIVE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE INHIBITOR;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER SUSCEPTIBILITY; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; HUMAN; HUMAN CELL; IC 50; IMMUNOPRECIPITATION; IN VITRO STUDY; METASTASIS POTENTIAL; MORPHOLOGY; PANCREAS CANCER; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; CELL MOTION; CELL PROLIFERATION; DRUG ANTAGONISM; DRUG EFFECT; DRUG SCREENING; ENZYMOLOGY; METABOLISM; METASTASIS; PANCREAS TUMOR; PATHOLOGY; TUMOR CELL LINE;

APOPTOSIS; CARBAZOLES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEOPLASM METASTASIS; PANCREATIC NEOPLASMS; PROTEIN KINASE INHIBITORS; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 84856071689     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-010-9422-6     Document Type: Article

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