Affinity maturation of antibodies requires integrity of the adult thymus

European Journal of Immunology

Volumn 42, Issue 2, 2012, Pages 500-510

  Abuattieh, Mouhammed ^a,b   Bender, Diane ^a   Liu, Esther ^a   Wettstein, Peter ^c   Platt, Jeffrey L ^a   Cascalho, Marilia ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b CHARLES UNIVERSITY   (Czech Republic)

^c Mayo Clinic College of Medicine   (United States)

Author keywords

Affinity maturation; Antibody secreting cells; Immunoglobulin; T cell repertoire; Thymus

Indexed keywords

ANTIBODY; IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY AFFINITY; ARTICLE; BINDING AFFINITY; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; EXON; FEMALE; MALE; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMECTOMY; THYMUS;

ANIMALS; ANTIBODY AFFINITY; ANTIBODY FORMATION; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELLS, CULTURED; CLONAL SELECTION, ANTIGEN-MEDIATED; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; THYMECTOMY; THYMUS GLAND;

EID: 84856060978     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201141889     Document Type: Article

References (32)

1. Manz, R. A., Arce, S., Cassese, G., Hauser, A. E., Hiepe, F. and Radbruch, A., Humoral immunity and long-lived plasma cells. Curr. Opin. Immunol. 2002. 14: 517-521.
2. Miller, J. F., Immunologic function of the thymus. Lancet 1961. 2: 748-749.
3. Miller, J. F., De Burgh, P. M. and Grant, G. A., Thymus and the production of antibody-plaque-forming cells. Nature 1965. 208: 1332-1334.
4. Miller, J. F., Effect of thymectomy in adult mice on immunological responsiveness. Nature 1965. 208: 1337-1338.
5. Metcalf, D., Delayed effect of thymectomy in adult life on immunological competence. Nature 1965. 208: 1336.
6. Taylor, R. B., Decay of immunological responsiveness after thymectomy in adult life. Nature 1965. 208: 1334-1335.
7. Kawabe, T., Naka, T., Yoshida, K., Tanaka, T., Fujiwara, H., Suematsu, S., Yoshida, N. et al., The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1994. 1: 167-178.
8. Korthauer, U., Graf, D., Mages, H. W., Briere, F., Padayachee, M., Malcolm, S., Ugazio, A. G. et al., Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature 1993. 361: 539-541.
9. Davies, E. G. and Thrasher, A. J., Update on the hyper immunoglobulin M syndromes. Br. J. Haematol. 2010. 149: 167-180.
10. Ogle, B. M., West, L. J., Driscoll, D. J., Strome, S. E., Razonable, R. R., Paya, C. V., Cascalho, M. and Platt, J. L., Effacing of the T cell compartment by cardiac transplantation in infancy. J. Immunol. 2006. 176: 1962-1967.
11. Gagnerault, M. C., Lanvin, O., Pasquier, V., Garcia, C., Damotte, D., Lucas, B. and Lepault, F., Autoimmunity during thymectomy-induced lymphopenia: role of thymus ablation and initial effector T cell activation timing in nonobese diabetic mice. J. Immunol. 2009. 183: 4913-4920.
12. Bourgeois, C., Hao, Z., Rajewsky, K., Potocnik, A. J. and Stockinger, B., Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen. Proc. Natl. Acad. Sci. USA 2008. 105: 8691-8696.
13. Alves, N. L., Richard-Le Goff, O., Huntington, N. D., Sousa, A. P., Ribeiro, V. S., Bordack, A., Vives, F. L. et al., Characterization of the thymic IL-7 niche in vivo. Proc. Natl. Acad. Sci. USA 2009. 106: 1512-1517.
14. Wettstein, P., Strausbauch, M., Therneau, T. and Borson, N., The application of real-time PCR to the analysis of T cell repertoires. Nucleic Acids Res. 2008. 36: e140.
15. Shannon, C., Warren, W., The Mathematical Theory of Communication. University of Illinois, Urbana 1949.
16. Elgueta, R., de Vries, V. C. and Noelle, R. J., The immortality of humoral immunity. Immunol. Rev. 2010. 236: 139-150.
17. Bothwell, A. L., Paskind, M., Reth, M., Imanishi-Kari, T., Rajewsky, K. and Baltimore, D., Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region. Cell 1981. 24: 625-637.
18. Takahashi, Y., Dutta, P. R., Cerasoli, D. M. and Kelsoe, G., In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J. Exp. Med. 1998. 187: 885-895.
19. Allen, D., Simon, T., Sablitzky, F., Rajewsky, K. and Cumano, A., Antibody engineering for the analysis of affinity maturation of an anti-hapten response. Embo J. 1988. 7: 1995-2001.
20. Paus, D., Phan, T. G., Chan, T. D., Gardam, S., Basten, A. and Brink, R., Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J. Exp. Med. 2006. 203: 1081-1091.
21. Phan, T. G., Paus, D., Chan, T. D., Turner, M. L., Nutt, S. L., Basten, A. and Brink, R., High affinity germinal center B cells are actively selected into the plasma cell compartment. J. Exp. Med. 2006. 203: 2419-2424.
22. O'Connor, B. P., Vogel, L. A., Zhang, W., Loo, W., Shnider, D., Lind, E. F., Ratliff, M. et al., Imprinting the fate of antigen-reactive B cells through the affinity of the B cell receptor. J. Immunol. 2006. 177: 7723-7732.
23. Lanzavecchia, A., Receptor-mediated antigen uptake and its effect on antigen presentation to class II-restricted T lymphocytes. Annu. Rev. Immunol. 1990. 8: 773-793.
24. Victora, G. D., Schwickert, T. A., Fooksman, D. R., Kamphorst, A. O., Meyer-Hermann, M., Dustin, M. L. and Nussenzweig, M. C., Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 2010. 143: 592-605.
25. Ahuja, A., Anderson, S. M., Khalil, A. and Shlomchik, M. J., Maintenance of the plasma cell pool is independent of memory B cells. Proc. Natl. Acad. Sci. USA 2008. 105: 4802-4807.
26. Mantchev, G. T., Cortesao, C., Rebrovich, M., Cascalho, M. and Bram, R. J., TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens. J. Immunol. 2007. 179: 2282-2288.
27. Giudicelli, V., Chaume, D. and Lefranc, M. P., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005. 33: D256-D261.
28. Kabat, E. A., Wu, T. T., Perry, H. M., Gottesman, K. S. and Foeller, C., Sequences of Proteins of Immunological Interest, 5th Edn, NIH, Bethesda, MD 1991.
29. Cascalho, M., Ma, A., Lee, S., Masat, L. and Wabl, M., A quasi-monoclonal mouse. Science 1996. 272: 1649-1652.
30. Billingham, R. E., Brent, L. and Medawar, P. B., Actively acquired tolerance of foreign cells. Nature 1953. 172: 603-606.
31. Sempowski, G. D. and Rhein, M. E., Measurement of mouse T cell receptor excision circles. Curr. Protoc. Immunol. 2004. Chapter 10: Unit 10 31.
32. Cascalho, M., Wong, J. and Wabl, M., VH gene replacement in hyperselected B cells of the quasimonoclonal mouse. J. Immunol. 1997. 159: 5795-5801.