Modeling partial Monosomy for human chromosome 21q11.2-q21.1 reveals haploinsufficient genes influencing behavior and fat deposition

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Migdalska, Anna M ^a   van der Weyden, Louise ^a   Ismail, Ozama ^a   White, Jacqueline K ^a   Project, Sanger Mouse Genetics ^a   Sánchez Andrade, Gabriela ^a   Logan, Darren W ^a   Arends, Mark J ^b   Adams, David J ^a  

^a WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BEHAVIOR; BODY FAT; CHROMOSOME 21Q; CONTROLLED STUDY; EMBRYO; FATTY LIVER; GENE; GENE DELETION; HAPLOINSUFFICIENCY; LIPI GENE; LIPID DIET; LIPID STORAGE; MALE; MEMORY CONSOLIDATION; MEMORY DISORDER; MOUSE; NONHUMAN; OPEN FIELD TEST; PARTIAL MONOSOMY; SOCIAL INTERACTION; SUBCUTANEOUS FAT; SYNTENY; USP25 GENE; ANIMAL; ANIMAL BEHAVIOR; CELL LINE; CHROMOSOME 21; CHROMOSOME DELETION; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; MAZE TEST; METABOLISM; MONOSOMY; PHOTON ABSORPTIOMETRY; PHYSIOLOGY; RECOGNITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING;

ANIMALIA; MUS;

ABSORPTIOMETRY, PHOTON; ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, SOUTHERN; CELL LINE; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 21; DIET, HIGH-FAT; FEMALE; HAPLOINSUFFICIENCY; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MAZE LEARNING; MICE; MONOSOMY; RECOGNITION (PSYCHOLOGY); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84856051379     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029681     Document Type: Article

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