A rat model for studying the biological effects of circulating LDL in the choriocapillaris-BrM-RPE complex

American Journal of Pathology

Volumn 180, Issue 2, 2012, Pages 541-549

  Yin, Lili ^a   Shi, Yuhua ^b   Liu, Xiaojuan ^a   Zhang, Hongmei ^a   Gong, Yuanyuan ^a   Gu, Qing ^a   Wu, Xingwei ^a   Xu, Xun ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b JINLING HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B100; GELATINASE A; LIPID; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRUCH MEMBRANE; CELL INFILTRATION; CELL VIABILITY; CHOROID CAPILLARY LAYER; CONTROLLED STUDY; ELECTRON MICROSCOPY; ELECTRORETINOGRAM; EXPERIMENTAL MODEL; EXTRACELLULAR MATRIX; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; LIPID BLOOD LEVEL; MALE; MOUSE; NICK END LABELING; NONHUMAN; PHOTORECEPTOR CELL; PIGMENT EPITHELIUM; PRIORITY JOURNAL; RAT; RETINA; RETINA MACULA AGE RELATED DEGENERATION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; ANTIGENS, CD; APOLIPOPROTEIN B-100; BRUCH MEMBRANE; CAPILLARIES; ELECTRORETINOGRAPHY; IMMUNITY, CELLULAR; INTERLEUKIN-2; LIPIDS; LIPOPROTEINS, LDL; MACULAR DEGENERATION; MALE; MATRIX METALLOPROTEINASE 2; MICROSCOPY, ELECTRON; RATS; RATS, SPRAGUE-DAWLEY; RETINA; RETINAL PIGMENT EPITHELIUM; TISSUE INHIBITOR OF METALLOPROTEINASE-3;

EID: 84856023717     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2011.10.015     Document Type: Article

References (43)

1. N. Congdon, B. O'Colmain, C.C. Klaver, R. Klein, B. Munoz, D.S. Friedman, J. Kempen, H.R. Taylor, P. Mitchell Causes and prevalence of visual impairment among adults in the United States Arch Ophthalmol 122 2004 477 485
2. H.R. Taylor, G. Tikellis, L.D. Robman, C.A. McCarty, J.J. McNeil Vitamin E supplementation and macular degeneration: randomised controlled trial BMJ 325 2002 11
3. R.J. Klein, C. Zeiss, E.Y. Chew, J.Y. Tsai, R.S. Sackler, C. Haynes, A.K. Henning, J.P. SanGiovanni, S.M. Mane, S.T. Mayne, M.B. Bracken, F.L. Ferris, J. Ott, C. Barnstable, J. Hoh Complement factor H polymorphism in age-related macular degeneration Science 308 2005 385 389
4. I. Kaur, A. Hussain, N. Hussain, T. Das, A. Pathangay, A. Mathai, R. Nutheti, P.K. Nirmalan, S. Chakrabarti Analysis of CFH, TLR4, and APOE polymorphism in India suggests the Tyr402His variant of CFH to be a global marker for age-related macular degeneration Invest Ophthalmol Vis Sci 47 2006 3729 3735
5. V. Flood, W. Smith, J.J. Wang, F. Manzi, K. Webb, P. Mitchell Dietary antioxidant intake and incidence of early age-related maculopathy: the Blue Mountains Eye Study Ophthalmology 109 2002 2272 2278
6. U.M. Schmidt-Erfurth, C. Pruente Management of neovascular age-related macular degeneration Prog Retin Eye Res 26 2007 437 451
7. Eyetech Study Group Anti-vascular endothelial growth factor therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration: phase II study results Ophthalmology 110 2003 979 986
8. C.A. Curcio, M. Johnson, J.D. Huang, M. Rudolf Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration J Lipid Res 51 2010 451 467
9. J.D. Huang, J.B. Presley, M.F. Chimento, C.A. Curcio, M. Johnson Age-related changes in human macular Bruch's membrane as seen by quick-freeze/deep-etch Exp Eye Res 85 2007 202 218
10. L. Wang, C.M. Li, M. Rudolf, O.V. Belyaeva, B.H. Chung, J.D. Messinger, N.Y. Kedishvili, C.A. Curcio Lipoprotein particles of intraocular origin in human Bruch membrane: an unusual lipid profile Invest Ophthalmol Vis Sci 50 2009 870 877
11. G. Malek, C.M. Li, C. Guidry, N.E. Medeiros, C.A. Curcio Apolipoprotein B in cholesterol-containing drusen and basal deposits of human eyes with age-related maculopathy Am J Pathol 162 2003 413 425
12. C.A. Curcio, J.B. Presley, C.L. Millican, N.E. Medeiros Basal deposits and drusen in eyes with age-related maculopathy: evidence for solid lipid particles Exp Eye Res 80 2005 761 775
13. C.A. McCarty, A. Dowrick, J. Cameron, B. McGrath, L.D. Robman, P. Dimitrov, G. Tikellis, C. Nicolas, J. McNeil, R. Guymer Novel measures of cardiovascular health and its association with prevalence and progression of age-related macular degeneration: the CHARM Study BMC Ophthalmol 8 2008 25
14. N. Dashti, G. McGwin, C. Owsley, C.A. Curcio Plasma apolipoproteins and risk for age related maculopathy Br J Ophthalmol 90 2006 1028 1033
15. C.M. Li, J.B. Presley, X. Zhang, N. Dashti, B.H. Chung, N.E. Medeiros, C. Guidry, C.A. Curcio Retina expresses microsomal triglyceride transfer protein: implications for age-related maculopathy J Lipid Res 46 2005 628 640
16. C.A. Curcio, C.L. Millican, T. Bailey, H.S. Kruth Accumulation of cholesterol with age in human Bruch's membrane Invest Ophthalmol Vis Sci 42 2001 265 274
17. C.A. Curcio, J.B. Presley, G. Malek, N.E. Medeiros, D.V. Avery, H.S. Kruth Esterified and unesterified cholesterol in drusen and basal deposits of eyes with age-related maculopathy Exp Eye Res 81 2005 731 741
18. K.C. Hayes, S. Lindsey, Z.F. Stephan, D. Brecker Retinal pigment epithelium possesses both LDL and scavenger receptor activity Invest Ophthalmol Vis Sci 30 1989 225 232
19. S.W. Ryeom, R.L. Silverstein, A. Scotto, J.R. Sparrow Binding of anionic phospholipids to retinal pigment epithelium may be mediated by the scavenger receptor CD36 J Biol Chem 271 1996 20536 20539
20. N. Gordiyenko, M. Campos, J.W. Lee, R.N. Fariss, J. Sztein, I.R. Rodriguez RPE cells internalize low-density lipoprotein (LDL) and oxidized LDL (oxLDL) in large quantities in vitro and in vivo Invest Ophthalmol Vis Sci 45 2004 2822 2829
21. A.L. Yu, R.L. Lorenz, C. Haritoglou, A. Kampik, U. Welge-Lussen Biological effects of native and oxidized low-density lipoproteins in cultured human retinal pigment epithelial cells Exp Eye Res 88 2009 495 503
22. Y. Yamada, J. Tian, Y. Yang, R.G. Cutler, T. Wu, R.S. Telljohann, M.P. Mattson, J.T. Handa Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells J Neurochem 105 2008 1187 1197
23. R.B. Bhisitkul, B.J. Winn, O.T. Lee, J. Wong, S. Pereira Dde, T.C. Porco, X. He, P. Hahn, J.L. Dunaief Neuroprotective effect of intravitreal triamcinolone acetonide against photoreceptor apoptosis in a rabbit model of subretinal hemorrhage Invest Ophthalmol Vis Sci 49 2008 4071 4077
24. P. Walter, R.A. Widder, C. Luke, P. Konigsfeld, R. Brunner Electrophysiological abnormalities in age-related macular degeneration Graefes Arch Clin Exp Ophthalmol 237 1999 962 968
25. B. Feigl, B. Brown, J. Lovie-Kitchin, P. Swann The rod-mediated multifocal electroretinogram in aging and in early age-related maculopathy Curr Eye Res 31 2006 635 644
26. B. Feigl, B. Brown, J. Lovie-Kitchin, P. Swann Cone- and rod-mediated multifocal electroretinogram in early age-related maculopathy Eye (Lond) 19 2005 431 441
27. L. Bretillon, N. Acar, M.W. Seeliger, M. Santos, M.A. Maire, P. Juaneda, L. Martine, S. Gregoire, C. Joffre, A.M. Bron, C. Creuzot-Garcher ApoB100,LDLR-/- mice exhibit reduced electroretinographic response and cholesteryl esters deposits in the retina Invest Ophthalmol Vis Sci 49 2008 1307 1314
28. G. Malek, L.V. Johnson, B.E. Mace, P. Saloupis, D.E. Schmechel, D.W. Rickman, C.A. Toth, P.M. Sullivan, C. Bowes Rickman Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration Proc Natl Acad Sci U S A 102 2005 11900 11905
29. U. Schmidt-Erfurth, M. Rudolf, M. Funk, C. Hofmann-Rummelt, N.S. Franz-Haas, Z. Aherrahrou, U. Schlotzer-Schrehardt Ultrastructural changes in a murine model of graded Bruch membrane lipoidal degeneration and corresponding VEGF164 detection Invest Ophthalmol Vis Sci 49 2008 390 398
30. F.B. Sallo, E. Bereczki, T. Csont, P.J. Luthert, P. Munro, P. Ferdinandy, M. Santha, I. Lengyel Bruch's membrane changes in transgenic mice overexpressing the human biglycan and apolipoprotein b-100 genes Exp Eye Res 89 2009 178 186
31. M. Fujihara, E. Bartels, L.B. Nielsen, J.T. Handa A human apoB100 transgenic mouse expresses human apoB100 in the RPE and develops features of early AMD Exp Eye Res 88 2009 1115 1123
32. A.C. Provost, L. Vede, K. Bigot, N. Keller, A. Tailleux, J.P. Jais, M. Savoldelli, I. Ameqrane, E. Lacassagne, J.M. Legeais, B. Staels, M. Menasche, Z. Mallat, F. Behar-Cohen, M. Abitbol Morphologic and electroretinographic phenotype of SR-BI knockout mice after a long-term atherogenic diet Invest Ophthalmol Vis Sci 50 2009 3931 3942
33. M. Aumailley, B. Gayraud Structure and biological activity of the extracellular matrix J Mol Med 76 1998 253 265
34. G. Fassina, N. Ferrari, C. Brigati, R. Benelli, L. Santi, D.M. Noonan, A. Albini Tissue inhibitors of metalloproteases: regulation and biological activities Clin Exp Metastasis 18 2000 111 120
35. T.S. Johnson, J.L. Haylor, G.L. Thomas, M. Fisher, A.M. El Nahas Matrix metalloproteinases and their inhibitions in experimental renal scarring Exp Nephrol 10 2002 182 195
36. S.J. George Therapeutic potential of matrix metalloproteinase inhibitors in atherosclerosis Expert Opin Investig Drugs 9 2000 993 1007
37. L.C. Padgett, G.M. Lui, Z. Werb, M.M. LaVail Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 in the retinal pigment epithelium and interphotoreceptor matrix: vectorial secretion and regulation Exp Eye Res 64 1997 927 938
38. M.E. Marin-Castano, S.J. Elliot, M. Potier, M. Karl, L.J. Striker, G.E. Striker, K.G. Csaky, S.W. Cousins Regulation of estrogen receptors and MMP-2 expression by estrogens in human retinal pigment epithelium Invest Ophthalmol Vis Sci 44 2003 50 59
39. K.M. Yeow, N.S. Kishnani, M. Hutton, S.P. Hawkes, G. Murphy, D.R. Edwards Sorsby's fundus dystrophy tissue inhibitor of metalloproteinases-3 (TIMP-3) mutants have unimpaired matrix metalloproteinase inhibitory activities, but affect cell adhesion to the extracellular matrix Matrix Biol 21 2002 75 88
40. E.I. Deryugina, M.A. Bourdon, R.A. Reisfeld, A. Strongin Remodeling of collagen matrix by human tumor cells requires activation and cell surface association of matrix metalloproteinase-2 Cancer Res 58 1998 3743 3750
41. M. Suzuki, M. Kamei, H. Itabe, K. Yoneda, H. Bando, N. Kume, Y. Tano Oxidized phospholipids in the macula increase with age and in eyes with age-related macular degeneration Mol Vis 13 2007 772 778
42. M. Kamei, K. Yoneda, N. Kume, M. Suzuki, H. Itabe, K. Matsuda, T. Shimaoka, M. Minami, S. Yonehara, T. Kita, S. Kinoshita Scavenger receptors for oxidized lipoprotein in age-related macular degeneration Invest Ophthalmol Vis Sci 48 2007 1801 1807
43. K. Dastgheib, W.R. Green Granulomatous reaction to Bruch's membrane in age-related macular degeneration Arch Ophthalmol 112 1994 813 818