Synthesis and evaluation of hexahydropyrrolo[3,4-d]isoxazole-4,6-diones as anti-stress agents

European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 81-91

  Badru, Rahul ^a   Anand, Preet ^a   Singh, Baldev ^a  

^a PUNJABI UNIVERSITY   (India)

Author keywords

Acute immobilization stress; Behavioral alterations; Cycloaddition; Pyrrolo isoxazoles; Stereoisomers

Indexed keywords

3 (2 CHLOROPHENYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (2 HYDROXYPHENYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (2 METHOXYPHENYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (2 TOLYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (3 CHLOROPHENYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (3 HYDROXYPHENYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (3 METHOXYPHENYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (3 TOLYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (4 CHLOROPHENYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (4 HYDROXYPHENYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (4 METHOXYPHENYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; 3 (4 TOLYL)DIHYDRO 5 (NAPHTHALEN 1 YL) 2 PHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; DIAZEPAM; DIHYDRO 5 (NAPHTHALEN 1 YL) 2,3 DIPHENYL 2H PYRROL[3,4 D]ISOXAZOLE 4,6(5H,6AH)DIONE; HEXAHYDROPYRROLO[3,4 D]ISOXAZOLE 4,6 DIONE DERIVATIVE; ISOXAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ACUTE STRESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CIS ISOMER; CONTROLLED STUDY; CYCLOADDITION; DRUG STRUCTURE; DRUG SYNTHESIS; IMMOBILIZATION; MALE; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; TRANS ISOMER;

ANIMALS; ANTI-ANXIETY AGENTS; BEHAVIOR, ANIMAL; IMMOBILIZATION; ISOXAZOLES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; MOLECULAR STRUCTURE; PYRROLES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRESS, PHYSIOLOGICAL;

EID: 84856019523     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.11.037     Document Type: Article

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