Effect of polymer molecular weight on the structural properties of non aqueous ethyl cellulose gels intended for topical drug delivery

Carbohydrate Polymers

Volumn 88, Issue 1, 2012, Pages 382-388

  Bruno, Lilia ^a   Kasapis, Stefan ^b   Heng, Paul W S ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b RMIT UNIVERSITY   (Australia)

Author keywords

Ethyl cellulose; Molecular weight; Propylene glycol dicaprylate; Rheology

Indexed keywords

ATR FTIR; ATTENUATED TOTAL REFLECTANCE FOURIER TRANSFORM INFRARED SPECTROSCOPY; CRITICAL GELATION TEMPERATURES; DYNAMIC OSCILLATIONS; ETHYL CELLULOSE; EXPERIMENTAL TECHNIQUES; NON-AQUEOUS; NON-AQUEOUS SOLVENTS; POLYMER CONCENTRATIONS; POLYMER MOLECULAR WEIGHT; PROPYLENE GLYCOL DICAPRYLATE; PROPYLENE GLYCOLS; TANGIBLE EVIDENCE; TIME AND TEMPERATURE DEPENDENCE; VISCOELASTIC FUNCTIONS; VISCOELASTIC RELAXATION; WEIGHT-AVERAGE MOLECULAR WEIGHT; WIDE-ANGLE X-RAY DIFFRACTION;

CELLULOSE; COAGULATION; DRUG DELIVERY; FOURIER TRANSFORM INFRARED SPECTROSCOPY; FRACTAL DIMENSION; GELATION; GLYCOLS; MOLECULAR WEIGHT; PROPYLENE; RHEOLOGY; X RAY DIFFRACTION;

POLYMERS;

EID: 84856018004     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2011.12.031     Document Type: Article

References (33)

1. M.A.V. Axelos, and M. Kolb Crosslinked biopolymers: Experimental evidence for scalar percolation theory Physical Review Letters 64 1990 1457 1460
2. G. Bonacucina, M. Cespi, M. Misici-Falzi, and G.F. Palmieri Rheological, adhesive and release characterization of semisolid carbopol/tetraglycol systems International Journal of Pharmaceutics 307 2006 129 140 (Pubitemid 41820405)
3. Bruno, L., Kasapis, S., & Heng, P. W. S. Effect of hydration on the structural properties of non-aqueous ethylcellulose gels intended for topical drug delivery. International Journal of Biological Macromolecules, in press.
4. L. Bruno, S. Kasapis, K.T. Chaudhary Chow, P.W.S. Heng, and L.P. Leong Temperature and time effects on the structural properties of a non-aqueous ethylcellulose topical drug delivery system Carbohydrate Polymers 86 2011 644 651
5. F. Chambon, and H.H. Winter Stopping of crosslinking reaction in a PDMS polymer at the gel point Polymer Bulletin 13 1985 499 503 (Pubitemid 15546294)
6. F. Chambon, and H.H. Winter Linear viscoelasticity at the gel point of a cross-linking PDMS with imbalanced stoichiometry Journal of Rheology 31 1987 683 697
7. +-κ-carrageenan as a weak gel Carbohydrate Polymers 50 2002 109 116
8. K.T. Chow, L.W. Chan, and P.W.S. Heng Formulation of hydrophilic non aqueous gel: Drug stability in different solvents and rheological behavior of gel matrices Pharmaceutical Research 25 2008 207 217
9. G. Cuvelier, C. Peigney-Nourry, and B. Launay Viscoelastic properties of physical gels: Critical behavior at the gel point G.O. Phillips, D.J. Wedlock, P.A. Williams, Gums and stabilisers for the food industry 5 1990 Oxford University Press Oxford/New York/Tokyo 549 552
10. T.-A.L. Do, J.R. Mitchell, B. Wolf, and J. Vieira Use of ethylcellulose polymers as stabilizer in fat-based food suspensions examined on the example of model reduced-fat chocolate Reactive and Functional Polymers 70 2010 856 862
11. J.K. Ferry Viscoelastic properties of polymers 3rd ed. 1980 Wiley New York
12. P.J. Flory Molecular theory of liquid crystal M. Gordon, Advances in polymer science #59: Liquid crystal polymers I 1984 Springer 1 36
13. H. Hara, T. Satoh, T. Toya, S. Iida, and S. Orii Cholesteric liquid crystalline polyesters. 1. Cholesteric liquid crystalline copolyesters based on poly(chloro-1,4-phenylene trans-1,4-cyclohexanedicarboxylate Macromolecules 21 1988 14 19 (Pubitemid 18606438)
14. P.W.S. Heng, L.W. Chan, and K.T. Chow Development of novel nonaqueous ethylcellulose gel matrices: Rheological and mechanical characterization Pharmaceutical Research 22 2005 676 684 (Pubitemid 40603266)
15. C.W. Hoogendam, A. de Keizer, M.A. Cohen Stuart, B.H. Bijsterbosch, J.A.M. Smit, and J.A.P.P. van Dijk Persistence length of carboxymethyl cellulose as evaluated from size exclusion chromatography and potentiometric titrations Macromolecules 31 1998 6297 6309 (Pubitemid 128563409)
16. S. Hsu, and A.M. Jamieson Viscoelastic behaviour at the thermal sol-gel transition of gelatin Polymer 34 1993 2602 2608
17. B. Huang, J.J. Ge, Y. Li, and H. Hou Aliphatic acid esters of (2 hydroxypropyl) cellulose - Effect of side chain length on properties of cholesteric liquid crystals Polymer 48 2007 264 269 (Pubitemid 44918052)
18. H. Itagaki, M. Tokai, and T. Kondo Physical gelation process for cellulose whose hydroxyl groups are regioselectively substituted by fluorescent groups Polymer 38 1997 4201 4205 (Pubitemid 127427261)
19. 2 liquid crystalline mesophases Polymer 39 1998 1123 1127 (Pubitemid 128397525)
20. L. Li, and Y. Aoki Rheological images of poly(vinyl chloride) gels. 3. Elasticity evolution and the scaling law beyond the sol-gel transition Macromolecules 31 1998 740 745 (Pubitemid 128557169)
21. Y.G. Lin, D.T. Mallin, J.C.W. Chien, and H.H. Winter Dynamic mechanical measurement of crystallization induced gelation in thermoplastic elastomeric poly(propylene) Macromolecules 24 1991 850 854
22. E. Lizaso, M.E. Munoz, and A. Santamaria Formation of gels in ethylcellulose solutions. An interpretation from dynamic viscoelastic results Macromolecules 32 1999 1883 1889
23. M. Muthukumar Screening effect on viscoelasticity near the gel point Macromolecules 22 1989 4656 4658
24. M. Muthukumar Dynamics of polymeric fractals Journal of Chemical Physics 83 1985 3161 3168
25. B. Nystrom, H. Walderhaug, and F.K. Hansen Rheological behavior during thermoreversible gelation of aqueous mixtures of ethyl(hydroxyethyl)cellulose and surfactants Langmuir 11 1995 750 757
26. R. Sanchez, J.M. Franco, M.A. Delgado, C. Valencia, and C. Gallegos Thermal and mechanical characterization of cellulosic derivatives-based oleogels potentially applicable as biolubricating greases: Influence of ethyl cellulose molecular weight Carbohydrate Polymers 83 2011 151 158
27. D. Shen, C. Wan, and S. Gao Molecular weight effects on gelation and rheological properties of konjac glucomannan-xanthan mixtures Journal of Polymer Science, Part B: Polymer Physics 48 2010 313 321
28. P. Sixou, J. Lematre, A. Ten Bosch, J.M. Gilli, and S. Dayan The circular dichroism of cholesteric cellulose acetate solutions: Dependence on molecular weight Molecular Crystals and Liquid Crystals 91 1983 277 283
29. S. Sun, T.J. Foster, W. MacNaughtan, J.R. Mitchell, D. Fenn, and A. Koschella Self-association of cellulose ethers with random and regioselective distribution of substitution Journal of Polymer Science, Part B: Polymer Physics 47 2009 1743 1752
30. L. Tan, D. Pan, and N. Pan Gelation behavior of polyacrylonitrile solution in relation to aging process and gel concentration Polymer 49 2008 5676 5682
31. K. Te Nijenhuis, and H.H. Winter Mechanical properties at the gel point of a crystallizing poly(vinylchloride) solution Macromolecules 22 1989 411 414
32. H.H. Winter, A. Izuka, and M.E. De Rosa Experimental observation of the molecular weight dependence of the critical exponents for the rheology near the gel point Polymer Gels and Networks 2 1994 239 245
33. Y. Zhang, X. Xu, J. Xu, and L. Zhang Dynamic viscoelastic behavior of triple helical lentinan in water: Effects of concentration and molecular weight Polymer 48 2007 6681 6690 (Pubitemid 47552516)