Centrosomal dysregulation in human metastatic melanoma cell lines

Cancer Genetics

Volumn 204, Issue 9, 2011, Pages 477-485

  Charters, Geoffrey A ^a   Stones, Clare J ^a   Shelling, Andrew N ^b   Baguley, Bruce C ^a   Finlay, Graeme J ^a,b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b THE UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Centrosome; Genomic instability; Melanoma; Pericentrin

Indexed keywords

ALPHA TUBULIN; DNA; PERICENTRIN;

ARTICLE; BRAF GENE; CANCER CELL CULTURE; CARCINOGENESIS; CDKN2A GENE; CDKN2B GENE; CELL CYCLE REGULATION; CENTROSOME; CONTROLLED STUDY; DISEASE ACTIVITY; DNA SEQUENCE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE IDENTIFICATION; GENE MUTATION; GENETIC ASSOCIATION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MELANOMA; MELANOMA CELL; METASTASIS; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NRAS GENE; NUCLEOTIDE SEQUENCE; ONCOGENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SCORING SYSTEM; SEQUENCE ANALYSIS; SUPERNUMERARY CHROMOSOME; TP53 GENE; CHROMOSOMAL INSTABILITY; GENETICS; PATHOLOGY; PHYSIOLOGY; PLOIDY; TUMOR CELL LINE; ULTRASTRUCTURE;

CELL LINE, TUMOR; CENTROSOME; CHROMOSOMAL INSTABILITY; FLOW CYTOMETRY; HUMANS; MELANOMA; PLOIDIES;

EID: 84856013412     PISSN: 22107762     EISSN: 22107770     Source Type: Journal    
DOI: 10.1016/j.cancergen.2011.07.001     Document Type: Article

References (24)

1. Doxsey S. Re-evaluating centrosome function. Nat Rev Mol Cell Biol 2001, 2:688-698.
2. Fukasawa K. Oncogenes and tumour suppressors take on centrosomes. Nat Rev Cancer 2007, 7:911-924.
3. Ganem N.J., Godinho S.A., Pellman D. A mechanism linking extra centrosomes to chromosomal instability. Nature 2009, 460:278-282.
4. Pihan G.A., Purohit A., Wallace J., et al. Centrosome defects and genetic instability in malignant tumors. Cancer Res 1998, 58:3974-3985.
5. Kawamura K., Moriyama M., Shiba N., et al. Centrosome hyperamplification and chromosomal instability in bladder cancer. Eur Urol 2003, 43:505-515.
6. Pihan G.A., Purohit A., Wallace J., et al. Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. Cancer Res 2001, 61:2212-2219.
7. Kuo K.K., Sato N., Mizumoto K., et al. Centrosome abnormalities in human carcinomas of the gallbladder and intrahepatic and extrahepatic bile ducts. Hepatology 2000, 31:59-64.
8. Sphyris N., Harrison D.J. p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells. Oncogene 2005, 24:2184-2194.
9. Wass J., Zbroja R.A., Young G.A., et al. Malignant melanoma: analysis by DNA flow cytometry. Pathology (Phila) 1985, 17:475-480.
10. Ehlers J.P., Worley L., Onken M.D., Harbour J.W. Integrative genomic analysis of aneuploidy in uveal melanoma. Clin Cancer Res 2008, 14:115-122.
11. 3H]thymidine incorporation and soft agar clonogenic assays. Eur J Cancer 1994, 30A:1370-1376.
12. Parmar J., Marshall E.S., Charters G.A., et al. Radiation-induced cell cycle delays and p53 status of early passage melanoma cell lines. Oncol Res 2000, 12:149-155.
13. Davies H., Bignell G.R., Cox C., et al. Mutations of the BRAF gene in human cancer. Nature 2002, 417:949-954.
14. Charters G.A. Human metastatic melanoma in vitro 2007, The University of Auckland.
15. Izumi H., Matsumoto Y., Ikeuchi T., et al. BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells. Oncogene 2009, 28:2806-2820.
16. Kneisel L., Strebhardt K., Bernd A., et al. Expression of polo-like kinase (PLK1) in thin melanomas: a novel marker of metastatic disease. J Cutan Pathol 2002, 29:354-358.
17. Bartkova J., Lukas J., Guldberg P., et al. The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis. Cancer Res 1996, 56:5475-5483.
18. McDermott K.M., Zhang J., Holst C.R., et al. p16(INK4a) prevents centrosome dysfunction and genomic instability in primary cells. PLoS Biol 2006, 4:e51.
19. Haluska F.G., Tsao H., Wu H., et al. Genetic alterations in signaling pathways in melanoma. Clin Cancer Res 2006, 12:2301s-2307s.
20. Cui Y., Guadagno T.M. B-Raf(V600E) signaling deregulates the mitotic spindle checkpoint through stabilizing Mps1 levels in melanoma cells. Oncogene 2008, 27:3122-3133.
21. Cui Y., Borysova M.K., Johnson J.O., et al. Oncogenic B-Raf(V600E) induces spindle abnormalities, supernumerary centrosomes, and aneuploidy in human melanocytic cells. Cancer Res 2010, 70:675-684.
22. Kawamura K., Izumi H., Ma Z., et al. Induction of centrosome amplification and chromosome instability in human bladder cancer cells by p53 mutation and cyclin E overexpression. Cancer Res 2004, 64:4800-4809.
23. Tarapore P., Fukasawa K. Loss of p53 and centrosome hyperamplification. Oncogene 2002, 21:6234-6240.
24. Chae S., Yun C., Um H., et al. Centrosome amplification and multinuclear phenotypes are induced by hydrogen peroxide. Exp Mol Med 2005, 37:482-487.