Ascorbate-dependent decrease of the mucosal immune inflammatory response to gliadin in coeliac disease patients

Allergologia et Immunopathologia

Volumn 40, Issue 1, 2012, Pages 3-8

  Bernardo, D ^a   Martinez Abad B ^a   Vallejo Diez, S ^a   Montalvillo, E ^a   Benito, V ^a   Anta, B ^a   Fernandez Salazar L ^b   Blanco Quiros A ^a   Garrote, J A ^a,b   Arranz, E ^a  

^a CSIC   (Spain)

^b HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

Author keywords

Ascorbate; Coeliac disease; IL 15; Inhibition; Therapy

Indexed keywords

ALPHA INTERFERON; ASCORBIC ACID; CYTOKINE; GAMMA INTERFERON; GLIADIN; INTERLEUKIN 13; INTERLEUKIN 15; INTERLEUKIN 17; INTERLEUKIN 6; NITRITE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIOXIDANT ACTIVITY; ARTICLE; CELIAC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DUODENUM BIOPSY; EXPLANT; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN TISSUE; IMMUNOASSAY; IN VITRO STUDY; MALE; MUCOSA INFLAMMATION; MUCOSAL IMMUNITY; PROTEIN EXPRESSION; PROTEIN SECRETION; RECEPTOR DOWN REGULATION; SEROLOGY; SUPERNATANT; TISSUE CULTURE; VITAMIN SUPPLEMENTATION; WESTERN BLOTTING;

ADULT; AGED; ASCORBIC ACID; BIOPSY; CELIAC DISEASE; CYTOKINES; FEMALE; GLIADIN; HUMANS; IMMUNITY, MUCOSAL; INFLAMMATION; INTERLEUKIN-15; MALE; MIDDLE AGED;

EID: 84856013383     PISSN: 03010546     EISSN: 15781267     Source Type: Journal    
DOI: 10.1016/j.aller.2010.11.003     Document Type: Article

References (38)

1. Maki M., Collin P. Coeliac disease. Lancet 1997, 349:1755-1759.
2. Sollid L.M. Coeliac disease: dissecting a complex inflammatory disorder. Nat Rev Immunol 2002, 2:647-655.
3. Brandtzaeg P. The changing immunological paradigm in coeliac disease. Immunol Lett 2006, 105:127-139.
4. Nilsen E.M., Lundin K.E., Krajci P., Scott H., Sollid L.M., Brandtzaeg P. Gluten specific, HLA-DQ restricted T cells from coeliac mucosa produce cytokines with Th1 or Th0 profile dominated by interferon gamma. Gut 1995, 37:766-776.
5. Maiuri L., Ciacci C., Auricchio S., Brown V., Quaratino S., Londei M. Interleukin 15 mediates epithelial changes in celiac disease. Gastroenterology 2000, 119:996-1006.
6. Maiuri L., Ciacci C., Ricciardelli I., Vacca L., Raia V., Auricchio S., et al. Association between innate response to gliadin and activation of pathogenic T cells in coeliac disease. Lancet 2003, 362:30-37.
7. Jabri B., Sollid L.M. Mechanisms of disease: immunopathogenesis of celiac disease. Nat Clin Pract Gastroenterol Hepatol 2006, 3:516-525.
8. Clemente M.G., De Virgiliis S., Kang J.S., Macatagney R., Musu M.P., Di Pierro M.R., et al. Early effects of gliadin on enterocyte intracellular signalling involved in intestinal barrier function. Gut 2003, 52:218-223.
9. Ebert E.C. IL-15 converts human intestinal intraepithelial lymphocytes to CD94 producers of IFN-gamma and IL-10, the latter promoting Fas ligand-mediated cytotoxicity. Immunology 2005, 115:118-126.
10. Hue S., Mention J.J., Monteiro R.C., Zhang S., Cellier C., Schmitz J., et al. A direct role for NKG2D/MICA interaction in villous atrophy during celiac disease. Immunity 2004, 21:367-377.
11. Matysiak-Budnik T., Candalh C., Dugave C., Namane A., Cellier C., Cerf-Bensussan N., et al. Alterations of the intestinal transport and processing of gliadin peptides in celiac disease. Gastroenterology 2003, 125:696-707.
12. Meresse B., Chen Z., Ciszewski C., Tretiakova M., Bhagat G., Krausz T.N., et al. Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 2004, 21:357-366.
13. Cinova J., Palová-Jelínková L., Smythies L.E., Cerná M., Pecharová B., Dvorák M., et al. Gliadin Peptides Activate Blood Monocytes from Patients with Celiac Disease. J Clin Immunol 2007, 27.
14. McDonald P.P., Russo M.P., Ferrini S., Cassatella M.A. Interleukin-15 (IL-15) induces NF-kappaB activation and IL-8 production in human neutrophils. Blood 1998, 92:4828-4835.
15. Rossi M., Young J.W. Human dendritic cells: potent antigen-presenting cells at the crossroads of innate and adaptive immunity. J Immunol 2005, 175:1373-1381.
16. Ouaaz F., Arron J., Zheng Y., Choi Y., Beg A.A. Dendritic cell development and survival require distinct NF-kappaB subunits. Immunity 2002, 16:257-270.
17. Speirs K., Lieberman L., Caamano J., Hunter C.A., Scott P. Cutting edge: NF-kappa B2 is a negative regulator of dendritic cell function. J Immunol 2004, 172:752-756.
18. Calder V.L., Bondeson J., Brennan F.M., Foxwell B.M., Feldmann M. Antigen-specific T-cell downregulation by human dendritic cells following blockade of NF-kappaB. Scand J Immunol 2003, 57:261-270.
19. Maiuri M.C., De Stefano D., Mele G., Fecarotta S., Greco L., Troncone R., et al. Nuclear factor kappa B is activated in small intestinal mucosa of celiac patients. J Mol Med 2003, 81:373-379.
20. Ali S., Mann D.A. Signal transduction via the NF-kappaB pathway: a targeted treatment modality for infection, inflammation and repair. Cell Biochem Funct 2004, 22:67-79.
21. Bonizzi G., Karin M. The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 2004, 25:280-288.
22. Whiteside S.T., Israel A. I kappa B proteins: structure, function and regulation. Semin Cancer Biol 1997, 8:75-82.
23. Zandi E., Karin M. Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex. Mol Cell Biol 1999, 19:4547-4551.
24. Bowie A.G., O'Neill L.A. Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase. J Immunol 2000, 165:7180-7188.
25. Maiuri M.C., De Stefano D., Mele G., Iovine B., Bevilacqua M.A., Greco L., et al. Gliadin increases iNOS gene expression in interferon-gamma-stimulated RAW 264.7 cells through a mechanism involving NF-kappa B. Naunyn Schmiedebergs Arch Pharmacol 2003, 368:63-71.
26. Fais S., Maiuri L., Pallone F., De Vincenzi M., De Ritis G., Troncone R., et al. Gliadin induced changes in the expression of MHC-class II antigens by human small intestinal epithelium. Organ culture studies with coeliac disease mucosa. Gut 1992, 33:472-475.
27. Beckett C.G., Dell'Olio D., Shidrawi R.G., Rosen-Bronson S., Ciclitira P.J. Gluten-induced nitric oxide and pro-inflammatory cytokine release by cultured coeliac small intestinal biopsies. Eur J Gastroenterol Hepatol 1999, 11:529-535.
28. Murray I.A., Daniels I., Coupland K., Smith J.A., Long R.G. Increased activity and expression of iNOS in human duodenal enterocytes from patients with celiac disease. Am J Physiol Gastrointest Liver Physiol 2002, 283. [G319-26].
29. Di Sabatino A., Ciccocioppo R., Cupelli F., Cinque B., Millimaggi D., Clarkson M.M., et al. Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease. Gut 2006, 55:469-477.
30. Bernardo D., Garrote J.A., Fernandez-Salazar L., Riestra S., Arranz E. Is gliadin really safe for non-coeliac individuals? Production of interleukin 15 in biopsy culture from non-coeliac individuals challenged with gliadin peptides. Gut 2007, 56:889-890.
31. De Stefano D., Maiuri M.C., Iovine B., Ialenti A., Bevilacqua M.A., Carnuccio R. The role of NF-kappaB, IRF-1, and STAT-1alpha transcription factors in the iNOS gene induction by gliadin and IFN-gamma in RAW 264.7 macrophages. J Mol Med 2006, 84:65-74.
32. Ohteki T., Tada H., Ishida K., Sato T., Maki C., Yamada T., et al. Essential roles of DC-derived IL-15 as a mediator of inflammatory responses in vivo. J Exp Med 2006, 203:2329-2338.
33. Tan P.H., Sagoo P., Chan C., Yates J.B., Campbell J., Beutelspacher S.C., et al. Inhibition of NF-kappa B and oxidative pathways in human dendritic cells by antioxidative vitamins generates regulatory T cells. J Immunol 2005, 174:7633-7644.
34. Sun P., Li D., Dong B., Qiao S., Maa X., Chen X. Vitamin C: an immunomodulator that attenuates anaphylactic to soybean glycinin hypersensitivity in a swine model. Food Chem 2009, 113:914-918.
35. Fang J.C., Kinlay S., Beltrame J., Hikiti H., Wainstein M., Behrendt D., et al. Effect of vitamins C and E on progression of transplant-associated arteriosclerosis: a randomised trial. Lancet 2002, 359:1108-1113.
36. Behrendt D., Beltrame J., Hikiti H., Wainstein M., Kinlay S., Selwyn A.P., et al. Impact of coronary endothelial function on the progression of cardiac transplant-associated arteriosclerosis: effect of anti-oxidant vitamins C and E. J Heart Lung Transplant 2006, 25:426-433.
37. Weeks B.S., Perez P.P. A novel vitamin C preparation enhances neurite formation and fibroblast adhesion and reduces xenobiotic-induced T-cell hyperactivation. Med Sci Monit 2007, 13:BR51-BR58.
38. Winkler C., Schroecksnadel K., Schennach H., Fuchs D. Vitamin C and E suppress mitogen-stimulated peripheral blood mononuclear cells in vitro. Int Arch Allergy Immunol 2007, 142:127-132.