Mitochondria as pharmacological targets

British Journal of Pharmacology

Volumn 160, Issue 2, 2010, Pages 217-219

  Moncada, S ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; Cancer; Metabolic disease; Nitric oxide; Reactive oxygen species; Respiration; Signalling

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ISOFLURANE; PIRACETAM; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID;

CENTRAL NERVOUS SYSTEM; DRUG MECHANISM; DRUG TARGETING; HEART; METABOLIC DISORDER; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NEOPLASM; NEUROTOXICITY; NONHUMAN; NOTE; OXIDATION REDUCTION STATE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; DRUG DELIVERY SYSTEMS; HUMANS; MITOCHONDRIA; MYOCARDIAL INFARCTION; NEOPLASMS; NEURODEGENERATIVE DISEASES; SIGNAL TRANSDUCTION;

EID: 77951685250     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00706.x     Document Type: Note

References (15)

1. Cadenas E, Davies KJA (2000). Mitochondrial free radical generation, oxidative stress, and aging. Free Radic Biol Med 29 : 222 230.
2. Calle EE, Kaaks R (2004). Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 4 : 579 591. (Pubitemid 39025053)
3. Chen XJ, Butow RA (2005). The organization and inheritance of the mitochondrial genome. Nat Rev Genet 6 : 815 825.
4. Dewson G, Kluck RM (2009). Mechanisms by which Bak and Bax permeabilise mitochondria during apoptosis. J Cell Sci 122 : 2801 2808.
5. Green DR, Reed JC (1998). Mitochondria and apoptosis. Science 281 : 1309 1312. (Pubitemid 28406816)
6. Guzy RD, Schumacher PT (2006). Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia. Exp Physiol 91 : 807 819.
7. Kurz C, Ungerer I, Lipka U, Kirr S, Schütt T, Eckert A et al 2010). The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by β-amyloid peptide. Br J Pharmacol 160 : 246 257.
8. Lane N (2005). Power, Sex, Suicide: Mitochondria and the Meaning of Life. OUP
9. Moncada S, Erusalimsky JD (2002). Does nitric oxide modulate mitochondrial energy generation and apoptosis? Nat Rev Mol Cell Biol 3 : 214 220. (Pubitemid 37237144)
10. Murphy MP (2009). How mitochondria produce reactive oxygen species. Biochem J 417 : 1 13.
11. Nisoli E, Clementi E, Carruba M, Moncada S (2007). Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome? Circ Res 100 : 795 806. (Pubitemid 46555684)
12. Pravdic D, Mio Y, Sedlic F, Pratt PF, Warltier DC, Bosnjak ZJ et al 2010). Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol-independent action at reperfusion. Br J Pharmacol 160 : 220 232.
13. Puerta E, Hervias I, Goñi-Allo B, Zhang SF, Jordán J, Starkov AA et al 2010). Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice: a possible mechanism underlying neurotoxicity. Br J Pharmacol 160 : 233 245.
14. Taylor C, Moncada S (2009). Nitric oxide, cytochrome c oxidase and the cellular response to hypoxia. Arterioscler Thromb Vasc Biol. Published online August 27, 2009, doi: 10.1161/ATVBAHA.108.181628.
15. Vander Heiden MG, Cantley LC, Thompson CB (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324 : 1029 1033.