Synthesis of novel 1,3-diaryl pyrazole derivatives bearing rhodanine-3-fatty acid moieties as potential antibacterial agents

European Journal of Medicinal Chemistry

Volumn 48, Issue , 2012, Pages 174-178

  Xu, Li Li ^a   Zheng, Chang Ji ^a   Sun, Liang Peng ^a   Miao, Jing ^a   Piao, Hu Ri ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

1,3 Diaryl pyrazole; Antibacterial activity; Rhodanine 3 fatty acid

Indexed keywords

1,3 DIARYL 4 FORMYLPYRAZOLE; 1,3 DIARYL PYRAZOLE DERIVATIVE; 2 [4 OXO 5 [[1 PHENYL 3 (4 TOLYL) 1H PYRAZOL 4 YL]METHYLENE] 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [(1,3 DIPHENYL 1H PYRAZOL 4 YL)METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (2 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (2 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (2 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (2,4 DICHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (2,4 DIMETHYLPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (3 BROMOPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (3 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (3 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (4 BROMOPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (4 FLUOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (4 METHOXYPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (4 NITROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 2 [5 [[3 (NAPHTHALEN 2 YL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]ACETIC ACID; 3 [5 [[3 (2,4 DICHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]PROPANOIC ACID; 3 [5 [[3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]PROPANOIC ACID; 4 [5 [[3 (2,4 DICHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2-THIOXOTHIAZOLIDIN 3 YL]BUTANOIC ACID; 4 [5 [[3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]BUTANOIC ACID; 5 [5 [[3 (2,4 DICHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]PENTANOIC ACID; 5 [5 [[3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]PENTANOIC ACID; 6 [5 [[3 (2,4 DICHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]HEXANOIC ACID; 6 [5 [[3 (4 CHLOROPHENYL) 1 PHENYL 1H PYRAZOL 4 YL]METHYLENE] 4 OXO 2 THIOXOTHIAZOLIDIN 3 YL]HEXANOIC ACID; ANTIINFECTIVE AGENT; NORFLOXACIN; OXACILLIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; FATTY ACID ANALYSIS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; VILSMEIER HAACK REACTION;

ANTI-BACTERIAL AGENTS; FATTY ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PYRAZOLES; RHODANINE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84855993241     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.12.011     Document Type: Article

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