Purinergic P2X 3 heteroreceptors enhance parasympathetic motor drive in isolated porcine detrusor, a reliable model for development of P2X selective blockers for detrusor hyperactivity

Pharmacological Research

Volumn 65, Issue 1, 2012, Pages 129-136

  D'Agostino, Gianluigi ^a   Condino, Anna Maria ^a   Calvi, Valentina ^a   Boschi, Federica ^a   Gioglio, Luciana ^a   Barbieri, Annalisa ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Detrusor hyperactivity; Parasympathetic; Porcine detrusor; Purinergic heteroreceptors

Indexed keywords

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; PURINERGIC P2X RECEPTOR; PURINERGIC P2X3 RECEPTOR; PURINERGIC P2X RECEPTOR ANTAGONIST;

ACETYLCHOLINE RELEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DETRUSOR MUSCLE; MALE; MOTOR CONTROL; NEUROMUSCULAR FUNCTION; NONHUMAN; PARASYMPATHETIC TONE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SMOOTH MUSCLE CONTRACTION; ANIMAL; BLADDER; CHOLINERGIC SYSTEM; DOSE RESPONSE; DRUG EFFECT; ELECTROSTIMULATION; HYDROLYSIS; IN VITRO STUDY; INNERVATION; METABOLISM; MOTONEURON; MUSCLE CONTRACTION; OVERACTIVE BLADDER; PATHOPHYSIOLOGY; SMOOTH MUSCLE; SWINE; SYNAPTIC TRANSMISSION; TIME;

ACETYLCHOLINE; ADENOSINE TRIPHOSPHATE; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; HYDROLYSIS; MOTOR NEURONS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PARASYMPATHETIC NERVOUS SYSTEM; PURINERGIC P2X RECEPTOR ANTAGONISTS; RECEPTORS, PURINERGIC P2X3; SWINE; SYNAPTIC TRANSMISSION; TIME FACTORS; URINARY BLADDER; URINARY BLADDER, OVERACTIVE;

EID: 84855986797     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2011.10.002     Document Type: Article

References (40)

1. G. Burnstock Cotransmission Curr Opin Pharmacol 4 2004 47 52 (Pubitemid 38145837)
2. G. Burnstock Purinergic cotransmission Exp Physiol 94 2008 20 24
3. R.A. North Molecular physiology of P2X receptors Physiol Rev 82 2002 1013 1067
4. G. Burnstock, and G.E. Knight Cellular distribution and functions of P2 receptor subtypes in different systems Int Rev Cytol 240 2004 31 304 (Pubitemid 39539202)
5. M.R. Ruggieri Mechanisms of disease: role of purinergic signaling in the pathophysiology of bladder dysfunction Nat Clin Pract Urol 3 2006 206 215
6. G. Burnstock Physiology and pathophysiology of purinergic neurotransmission Physiol Rev 87 2007 659 797 (Pubitemid 47084682)
7. K.E. Andersson, and A.J. Wein Pharmacology of the lower urinary tract: basis for current and future treatments of urinary incontinence Pharmacol Rev 56 2004 581 631 (Pubitemid 40003785)
8. V. Kumar, C. Chapple, and R. Chess-Williams Characteristics of adenosine triphosphatase release from porcine and human normal bladder J Urol 172 2004 744 747 (Pubitemid 38900253)
9. M. Wust, B. Averbeck, S. Reifa, M. Braterb, and U. Ravens Different responses to drugs against overactive bladder in detrusor muscle of pig, guinea pig and mouse Eur J Pharmacol 454 2002 59 69 (Pubitemid 35284367)
10. M. Bayliss, C. Wu, D. Newgreen, A.R. Mundy, and C.H. Fry A quantitative study of atropine-resistant contractile responses in human detrusor smooth muscle, from stable, unstable and obstructed bladders J Urol 162 1999 1833 1839 (Pubitemid 29474738)
11. D.E. Rapp, M.B. Lyon, G.T. Bales, and S.P. Cook A role for the P2X receptor in urinary tract physiology and in the pathophysiology of urinary dysfunction Eur Urol 48 2005 303 308 (Pubitemid 40957109)
12. M. Yoshida, Y. Homma, A. Inadome, M. Yono, H. Seshita, and Y. Miyamoto Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscles Exp Geron 36 2001 99 109 (Pubitemid 32012570)
13. R.A. Harvey, D.E. Skennerton, D. Newgreen, and C.H. Fry The contractile potency of adenosine triphosphate and ecto-adenosine triphosphatase activity in guinea pig detrusor and detrusor from patients with a stable, unstable or obstructed bladder J Urol 168 2002 1235 1239
14. S. Palea, W. Artibani, E. Ostardo, D.G. Trist, and C. Pietra Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis J Urol 150 1993 2007 2012 (Pubitemid 24350854)
15. B.A. O'Reilly, A.H. Kosaka, G.F. Knight, T.K. Chang, A.P. Ford, and J.M. Rymer P2X receptors and their role in female idiopathic detrusor instability J Urol 167 2002 157 164 (Pubitemid 34024522)
16. C.H. Fry, M. Bayliss, J.S. Young, and M. Hussain Influence of age and bladder dysfunction on the contractile properties of isolated human detrusor smooth muscle BJU 108 2b 2011 E91 E96
17. A.L. Smith, and A.J. Wein Recent advances in the development of antimuscarinic agents for overactive bladder Trends Pharmacol Sci 31 2010 470 475
18. C. Boselli, S. Govoni, A.M. Condino, and G. D'Agostino Bladder instability: a re-appraisal of classic experimental approaches and development of new therapeutic strategies J Auton Pharmacol 21 2001 219 229
19. G. D'Agostino, A. Condino, P. Gallinari, C. Boselli, A. Agazzi, and M. Tonini An appraisal of recently patented compounds for bladder overactivity and urinary incontinence Expert Opin Ther Patents 14 2004 1041 1060 (Pubitemid 39023092)
20. G. D'Agostino, A.M. Condino, P. Gallinari, G.P. Franceschetti, and M. Tonini Characterization of prejunctional serotonin receptors modulating [3H]Acetylcholine release in the human detrusor J Pharmacol Exp Ther 316 2006 129 135 (Pubitemid 41832589)
21. G. Burnstock Therapeutic potential of purinergic signaling for diseases of the urinary tract BJU Int 107 2011 192 204
22. C.M. Brady, A. Apostolidis, Y. Yiangou, P.A. Baecker, A.P. Ford, and A. Freeman P2X3-immunoreactive nerve fibres in neurogenic detrusor overactivity and the effect of intravesical resiniferatoxin Eur Urol 46 2004 247 253 (Pubitemid 38902749)
23. A.P. Ford, J.R. Gever, P.A. Nunn, Y. Zhong, J.S. Cefalu, and M.P. Dillon Purinoceptors as therapeutic targets for lower urinary tract dysfunction Br J Pharmacol 147 2006 132 143
24. N. Yoshimura, Y. Kaiho, M. Miyazato, T. Yunoki, C. Tai, and M.B. Chancellor Therapeutic receptor targets for lower urinary tract dysfunction Naunyn Schmiedebergs Arch Pharmacol 377 2008 437 448
25. H. Hashitani, and A.F. Brading Electrical properties of detrusor smooth muscles from the pig and human urinary bladder Br J Pharmacol 140 2003 146 158 (Pubitemid 37175840)
26. S. Kajioka, S. Nakayama, G. McMurray, K. Abe, and A.F. Brading Ca(2+) channel properties in smooth muscle cells of the urinary bladder from pig and human Eur J Pharmacol 443 2002 19 29 (Pubitemid 34603593)
27. S.A. Buckner, I. Milicic, A. Daza, R. Davis-Taber, V.E.S. Scott, and J.P. Sullivan Pharmacological and molecular analysis of ATP-sensitive Kq channels in the pig and human detrusor Eur J Pharmacol 400 2000 287 295 (Pubitemid 30438739)
28. D.J. Sellers, T. Yamanishi, C.R. Chapple, C. Couldwell, K. Yasuda, and R. Chess-Williams M3 muscarinic receptors but not M2 mediate contraction of the porcine detrusor muscle in vitro J Auton Pharmacol 20 2000 171 176 (Pubitemid 32050062)
29. T. Yamanishi, C.R. Chapple, K. Yasuda, and R. Chess-Williams The role of M2-muscarinic receptors in mediating contraction of the pig urinary bladder in vitro Br J Pharmacol 131 2000 1482 1488
30. T.P. Kenakin The Schild regression in the process of receptor classification Can J Physiol Pharmacol 60 1982 249 265 (Pubitemid 12144825)
31. M.F. Jarvis, B. Bianchi, J.T. Uchic, J. Cartmell, C.H. Lee, and M. Williams [3H]A-317491, a novel high-affinity non-nucleotide antagonist that specifically labels human P2X2/3 and P2X3 receptors J Pharmacol Exp Ther 310 2004 407 416 (Pubitemid 38812736)
32. T.D. Westfall, C. Kennedy, and P. Sneddon The ecto-ATPase inhibitor ARL 67156 enhances parasympathetic neurotransmission in the guinea-pig urinary bladder Eur J Pharmacol 329 1997 169 173 (Pubitemid 27270530)
33. B.S. Khakh, G. Burnstock, C. Kennedy, B.F. King, R.A. North, and P. Séguéla International Union of Pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits Pharmacol Rev 53 2001 107 118 (Pubitemid 32173110)
34. J. Rettinger, K. Braun, H. Hochmann, M.U. Kassack, H. Ullmann, and P. Nickel Profiling at recombinant homomeric and heteromeric rat P2X receptors identifies the suramin analogue NF449 as a highly potent P2X1 receptor antagonist Neuropharmacology 48 2005 461 468 (Pubitemid 40250009)
35. J.R. Gever, D.A. Cockayne, M.P. Dillon, G. Burnstock, and A.P. Ford Pharmacology of P2X channels Pflugers Arch 452 2006 513 537 (Pubitemid 44015088)
36. G.N. Sibley A comparison of spontaneous and nerve-mediated activity in bladder muscle from man, pig and rabbit J Physiol 354 1984 431 443 (Pubitemid 14066377)
37. K. Fuji Evidence for adenosine triphosphate as an excitatory transmitter in guinea-pig, rabbit and pig urinary bladder J Physiol 404 1988 39 52
38. V. Kumar, C.R. Chapple, D. Rosario, P.R. Tophill, and R. Chess-Williams In vitro release of adenosine triphosphate from the urothelium of human bladders with detrusor overactivity, both neurogenic and idiopathic Eur Urol 57 2010 1087 1092
39. Y. Sun, and T.C. Chai Up-regulation of P2X3 receptor during stretch of bladder urothelial cells from patients with interstitial cystitis J Urol 171 2004 448 452 (Pubitemid 37549209)
40. J.R. Gever, R. Soto, R.A. Henningsen, R.S. Martin, D.H. Hackos, and S. Panicker AF-353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist Br J Pharmacol 160 2010 1387 1398