Decreased axonal density and altered expression profiles of axonal guidance genes underlying lead (Pb) neurodevelopmental toxicity at early embryonic stages in the zebrafish

Neurotoxicology and Teratology

Volumn 33, Issue 6, 2011, Pages 715-720

  Zhang, Jun ^a,b   Peterson, Samuel M ^a   Weber, Gregory J ^a   Zhu, Xinqiang ^b   Zheng, Wei ^a   Freeman, Jennifer L ^a  

^a PURDUE UNIVERSITY   (United States)

^b ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Axon tract; Lead; Neurodevelopment; Neurotoxicity; Pb; Zebrafish

Indexed keywords

ALPHA TUBULIN; LEAD;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTERIOR COMMISSURE; ARTICLE; AXON DENSITY; AXON TRACT; AXONOGENESIS; BRAIN; BRAIN COMMISSURE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DIENCEPHALON; DOWN REGULATION; EMBRYO; EMBRYO DEVELOPMENT; EPHRIN TYPE A RECEPTOR 4B GENE; FERTILIZATION; FOREBRAIN; GENE; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; MESENCEPHALON; NERVE FIBER; NERVE FIBER GROWTH; NERVE TRACT; NETRIN1B GENE; NETRIN2 GENE; NEUROTOXICITY; NOIWAS GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; POST OPTIC COMMISSURE; POSTERIOR COMMISSURE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RHOMBENCEPHALON; SONIC HEDGEHOG A GENE; STAINING; SUPRAOPTIC NUCLEUS; TRACT OF POST OPTIC COMMISSURE; UPREGULATION; ZEBRA FISH;

ANIMALS; AXONAL TRANSPORT; AXONS; BRAIN; DISEASE MODELS, ANIMAL; EMBRYO, NONMAMMALIAN; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; LEAD POISONING, NERVOUS SYSTEM; REAL-TIME POLYMERASE CHAIN REACTION; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO;

EID: 84855957493     PISSN: 08920362     EISSN: 18729738     Source Type: Journal    
DOI: 10.1016/j.ntt.2011.07.010     Document Type: Article

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