Effects of orexin and glucose microinjected into the hypothalamic paraventricular nucleus on gastric acid secretion in conscious rats

Neurogastroenterology and Motility

Volumn 24, Issue 2, 2012, Pages

  Chaleek, N ^a   Kermani, M ^a   Eliassi, A ^a   Haghparast, A ^a  

^a SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Gastric acid secretion; Glucose; Hypothalamic paraventricular nucleus; Orexins; Pylorus ligation

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; GLUCOSE; OREXIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONSCIOUSNESS LEVEL; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; PYLORUS LIGATION; RAT; STOMACH ACID SECRETION;

ANIMALS; BENZOXAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC ACID; GASTRIC MUCOSA; GLUCOSE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICROINJECTIONS; NEUROPEPTIDES; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, WISTAR; UREA;

EID: 84855943206     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2011.01789.x     Document Type: Article

References (37)

1. Thorpe AJ, Kotz CM. Orexin A in the nucleus accumbens stimulates feeding and locomotor activity. Brain Res 2005; 1050: 156-62.
2. 2+ signaling in a reciprocal manner to leptin: orexigenic neuronal pathways in the mediobasal hypothalamus. Eur J Neurosci 2004; 19: 1524-34.
3. Sweet DC, Levine AS, Billington CJ, Kotz CM. Feeding response to central orexins. Brain Res 1999; 821: 535-8.
4. Dube MG, Kalra SP, Kalra PS. Food intake elicited by central administration of orexins/hypocretins: identification of hypothalamic sites of action. Brain Res 1999; 842: 473-7.
5. Takahashi N, Okumura T, Yamada H, Kohgo Y. Stimulation of gastric acid secretion by centrally administered orexin-A in conscious rats. Biochem Biophy Res Commun 1999; 254: 623-7.
6. Eliassi A, Nazari M, Naghdi N. Role of the ventromedial hypothalamic orexin-1 receptors in regulation of gastric acid secretion in conscious rats. J Neuroendocrinol 2009; 21: 177-82.
7. Backberg M, Hervieu G, Wilson S, Meister B. Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Eur J Neurosci 2002; 15: 315-28.
8. Edwards CM, Abusnana S, Sunter D, Murphy KG, Ghatei MA, Bloom SR. The effect of the orexins on food intake: comparison with neuropeptide Y, melanin-concentrating hormone and galanin. J Endocrinol 1999; 160: R7-12.
9. Shiraishi T. Hypothalamic control of gastric acid secretion. Brain Res Bull 1988; 20: 791-7.
10. Fioramonti X, Contie S, Song Z, Routh VH, Lorsignol A, Penicaud L. Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks? Diabetes 2007; 56: 1219-27.
11. Song Z, Levin BE, McArdle JJ, Bakhos N, Routh VH. Convergence of pre- and postsynaptic influences on glucosensing neurons in the ventromedial hypothalamic nucleus. Diabetes 2001; 50: 2673-81.
12. Wang R, Liu X, Hentges ST et al. The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides. Diabetes 2004; 53: 1959-65.
13. Shiraishi T. Effects of lateral hypothalamic stimulation on medulla oblongata and gastric vagal neural responses. Brain Res Bull 1980; 5: 245-50.
14. Marx J. Cellular warriors at the battle of the bulge. Science 2003; 299: 846-9.
15. Murphy BA, Fioramonti X, Jochnowitz N et al. Fasting enhances the response of arcuate neuropeptide Y-glucose-inhibited neurons to decreased extracellular glucose. Am J Physiol Cell Physiol 2009; 296: C746-56.
16. Mountjoy PD, Bailey SJ, Rutter GA. Inhibition by glucose or leptin of hypothalamic neurons expressing neuropeptide Y requires changes in AMP-activated protein kinase activity. Diabetologia 2007; 50: 168-77.
17. Liu XH, Morris R, Spiller D, White M, Williams G. Orexin A preferentially excites glucose-sensitive neurons in the lateral hypothalamus of the rat in vitro. Diabetes 2001; 50: 2431-7.
18. Cai XJ, Widdowson PS, Harrold J et al. Hypothalamic orexin expression: modulation by blood glucose and feeding. Diabetes 1999; 48: 2132-7.
19. Griffond B, Risold PY, Jacquemard C, Colard C, Fellmann D. Insulin-induced hypoglycemia increases preprohypocretin (orexin) mRNA in the rat lateral hypothalamic area. Neurosci Lett 1999; 262: 77-80.
20. Yamada H, Takahashi N, Tanno S, Nagamine M, Takakusaki K, Okumura T. A selective orexin-1 receptor antagonist, SB334867, blocks 2-DG-induced gastric acid secretion in rats. Neurosci Lett 2005; 376: 137-42.
21. Brown J. Effects of 2-deoxyglucose on carbohydrate metablism: review of the literature and studies in the rat. Metabolism 1962; 11: 1098-112.
22. Paxinos G WCs. The Rat Brain in Stereotaxic Coordinate, 4th edn. Orlando, FL: Academic Press; 2003.
23. Date Y, Nakazato M, Murakami N, Kojima M, Kangawa K, Matsukura S. Ghrelin acts in the central nervous system to stimulate gastric acid secretion. Biochem Biophys Res Commun 2001; 280: 904-7.
24. Takeda K, Nakata T, Takesako T et al. Sympathetic inhibition and attenuation of spontaneous hypertension by PVN lesions in rats. Brain Res 1991; 543: 296-300.
25. Lohman RJ, Liu L, Morris M, O'Brien TJ. Validation of a method for localised microinjection of drugs into thalamic subregions in rats for epilepsy pharmacological studies. J Neurosci Methods 2005; 146: 191-7.
26. Rodgers RJ, Halford JC, Nunes de Souza RL et al. SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats. Eur J Neurosci 2001; 13: 1444-52.
27. Haynes AC, Chapman H, Taylor C et al. Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice. Regul Pept 2002; 104: 153-9.
28. Blevins JE, Stanley BG, Reidelberger RD. DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus. Pharmacol Biochem Behav 2002; 71: 277-82.
29. Penicaud L, Leloup C, Fioramonti X, Lorsignol A, Benani A. Brain glucose sensing: a subtle mechanism. Curr Opin Clin Nutr Metab Care 2006; 9: 458-62.
30. Colombani AL, Carneiro L, Benani A et al. Enhanced hypothalamic glucose sensing in obesity: alteration of redox signaling. Diabetes 2009; 58: 2189-97.
31. Grossman SP. The role of glucose, insulin and glucagon in the regulation of food intake and body weight. Neurosci Biobehav Rev 1986; 10: 295-315.
32. Penicaud L, Thompson DA, Le Magnen J. Effects of 2-deoxy-D-glucose on food and water intake and body temperature in rats. Physiol Behav 1986; 36: 431-5.
33. Kar P, Price P, Sawers S, Bhattacharya S, Reznek RH, Grossman AB. Insulinomas may present with normoglycemia after prolonged fasting but glucose-stimulated hypoglycemia. J Clin Endocrinol Metab 2006; 91: 4733-6.
34. Routh VH. Glucose-sensing neurons: are they physiologically relevant? Physiol Behav 2002; 76: 403-13.
35. 2+ in orexin neurons of the rat lateral hypothalamus. Neurosci Lett 2001; 309: 165-8.
36. Yamanaka A, Beuckmann CT, Willie JT et al. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 2003; 38: 701-13.
37. Burdakov D, Gerasimenko O, Verkhratsky A. Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J Neurosci 2005; 25: 2429-33.