Evaluation of anti-influenza efficiency of polyclonal IgG antibodies specific to the ectodomain of M2 protein of influenza A virus by passive immunization of mice

Acta Virologica

Volumn 55, Issue 3, 2011, Pages 261-265

  Kiraly J ^a   Vareckova E ^a   Mucha, V ^a   Kostolansky F ^a  

^a INSTITUTE OF VIROLOGY   (Slovakia)

Author keywords

Em2 specific igg concentration; Influenza; M2 protein; Protection

Indexed keywords

FREUND ADJUVANT; IMMUNOGLOBULIN G; KEYHOLE LIMPET HEMOCYANIN; POLYCLONAL ANTIBODY; PROTEIN M2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; ASCITES; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EVALUATION; FEMALE; INFLUENZA A; INFLUENZA VIRUS A; LD 50; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PASSIVE IMMUNIZATION; QUANTITATIVE ANALYSIS; SURVIVAL;

ANIMALS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HEMOCYANIN; IMMUNIZATION; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN G; INFLUENZA A VIRUS; INFLUENZA VACCINES; MICE; MICE, INBRED BALB C; ORTHOMYXOVIRIDAE INFECTIONS; VIRAL MATRIX PROTEINS;

INFLUENZA A VIRUS; MUS;

EID: 84855939156     PISSN: 0001723X     EISSN: None     Source Type: Journal    
DOI: 10.4149/av_2011_03_261     Document Type: Article

References (20)

1. Beerli RR, Bauer M, Schmitz N, Buser RB, Gwerder M, Muntwiler S, Renner WA, Saudan P, Bachmann MF (2009): Prophylactic and therapeutic activity of fully human monoclonal antibodies directed against influenza A M2 protein. Virol. J. 6, 224. doi.org/10.1186/1743-422X-6-224
2. Ben-Yedidia T, Arnon R (2006): Flagella as a Platform for Epitope- Based Vaccines. Isr. Med. Assoc. J. 8, 316-318 8
3. De Filette M, Martens W, Roose K, Deroo T, Vervalle F, Bentahir M, Vandekerckhove J, Fiers W, Saelens X (2008): An influenza A vaccine based on tetrameric ectodomain of matrix protein 2. J. Biol. Chem. 283, 11382-11387. doi. org/10.1074/jbc.M800650200
4. Ey PL, Prowse SJ, Jenkin CR (1978): Isolation of pure IgG1, IgG2a and IgG2b immunoglobulins from mouse serum using Protein A-Sepharose. Immunochemistry 15, 429-436. doi.org/10.1016/0161-5890(78)90070-6
5. Feng J, Zhang M, Mozdzanowska K, Zharikova D, Hoff H, Wunner W, Couch RB, Gerhard W (2006): Influanza A virus infection engenders a poor antibody response against the ectodomain of matrix protein 2. Virol. J. 3, 102. doi. org/10.1186/1743-422X-3-102
6. Fu TM, Freed DC, Horton MS, Fan J, Citron MP, Joyce JG, Garsky VM, Casimiro DR, Zhao Q, Shiver JW, Liang X (2009): Characterizations of four monoclonal antibodies against M2 protein ectodomain of influenza A virus. Virology 385, 218-226. doi.org/10.1016/j.virol.2008.11.035
7. Huleatt JW, Nakaar V, Desai P, Huang Y, Hewitt D, Jacobs A, Tang J, Mcdonald W, Song L, Evans RK, Umlauf S, Tussey L, Powell TJ (2008): Potent immunogenicity and efficacy of a universal influenza vaccine candidate comprising a recombinant fusion protein linking influenza M2e to the TLR5 ligand flagellin. Vaccine 26, 201-214. doi. org/10.1016/j.vaccine.2007.10.062
8. Jegerlehner A, Schmitz N, Storni T, Bachmann MF (2004): Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibodydependent NK cell activity. J. Immunol. 172, 5598-5605.
9. Lamb RA, Zebedee SL, Richardson CD (1985): Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40, 627-633. doi. org/10.1016/0092-8674(85)90211-9
10. Liu W, Peng Z, Liu Z, Lu Y, Ding J, Chen YH (2004): High epitope density in a single recombinant protein molecule of the extracellular domain of influenza A virus M2 protein significantly enhances protective immunity. Vaccine 23, 366-371. doi.org/10.1016/j.vaccine.2004.05.028
11. Neirynck S, Deroo T, Saelens X, Vanlandschoot P, Jou WM, Fiers W (1999): A universal influenza A vaccine based on the extracellular domain of the M2 protein. Nat. Med. 5, 1157-1163. doi.org/10.1038/13484
12. Okuda K, Ihata A, Watabe S, Okada E, Yamakawa T, Hamajima K, Yang J, Ishii N, Nakazawa M, Okuda K, Ohnari K, Nakajima K, Xin KQ (2001): Protective immunity against influ-enza A virus induced by immunization with DNA plasmid containing influenza M gene. Vaccine 19, 3681-3691. doi. org/10.1016/S0264-410X(01)00078-0
13. Palese P, Garcia-Sastre A (2002): Influenza vaccines: present and future. J. Clin. Invest. 110, 9-13.
14. Slepushkin VA, Katz JM, Black RA, Gamble WC, Rota PA, Cox NJ (1995): Protection of mice against influenza A virus challenge by vaccination with baculovirusexpressed M2 protein. Vaccine 13, 1399-1402. doi.org/10.1016/0264- 410X(95)92777-Y
15. Staneková Z, Király J, Stropkovská A, Mikušková T, Mucha V, Kostolanský F, Varečková E (2011): Heterosubtypic protective immunity against influenza A virus induced by fusion peptide of the hemagglutinin in comparison to ectodomain of M2 protein. Acta Virol. 55, 61-67. doi. org/10.4149/av-2011-01-61
16. Sui Z, Chen Q, Wu R, Zhang H, Zheng M, Wang H, Chen Z (2010): Cross-protection against influenza virus infection by intranasal administration of M2-based vaccine with chitosan as an adjuvant. Arch. Virol. 155, 535-544. doi. org/10.1007/s00705-010-0621-4
17. Varečková E, Mucha V, Wharton SA, Kostolanský F (2003a): Inhibition of fusion activity of influenza A hemagglutinin mediated by HA2-specific monoclonal antibodies. Arch. Virol. 148, 469-486. doi.org/10.1007/s00705-002-0932-1
18. Wynne SA, Crowther RA, Leslie AG (1999): The crystal structure of the human hepatitis B virus capsid. Mol. Cell. 3, 771-780. doi.org/10.1016/S1097-2765(01)80009-5
19. Zebedee SL, Lamb RA (1988): Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions. J. Virol. 62, 2762-2772.
20. Zharikova D, Mozdzanowska K, Feng J, Zhang M, Gerhard W (2005): Influenza type A virus escape mutants emerge in vivo in the presence of antibodies to the ectodomain of matrix protein 2. J. Virol. 79, 6644-6654.