Characterizations of four monoclonal antibodies against M2 protein ectodomain of influenza A virus

Virology

Volumn 385, Issue 1, 2009, Pages 218-226

  Fu, Tong Ming ^a   Freed, Daniel C ^a   Horton, Melanie S ^a   Fan, Jiang ^a   Citron, Michael P ^a   Joyce, Joseph G ^a   Garsky, Victor M ^a   Casimiro, Danilo R ^a   Zhao, Qinjian ^a   Shiver, John W ^a   Liang, Xiaoping ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Influenza virus; M2 peptide vaccines; M2 protein; Monoclonal antibody

Indexed keywords

EPITOPE; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY L18; MONOCLONAL ANTIBODY O19; MONOCLONAL ANTIBODY P6; MONOCLONAL ANTIBODY S1; PEPTIDE VACCINE; PROTEIN M2; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN BINDING; ANTIVIRAL ACTIVITY; ARTICLE; BAGG ALBINO MOUSE; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNITY; INFLUENZA VIRUS A; MORTALITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROVOCATION TEST;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; ANTIVIRAL AGENTS; CELL LINE, TUMOR; CELLS, CULTURED; EPITOPE MAPPING; FEMALE; INFLUENZA A VIRUS; INFLUENZA VACCINES; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; ORTHOMYXOVIRIDAE INFECTIONS; PEPTIDE FRAGMENTS; VIRAL MATRIX PROTEINS;

ANIMALIA; INFLUENZA A VIRUS; MUS; ORTHOMYXOVIRIDAE;

EID: 60349087488     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2008.11.035     Document Type: Article

References (30)

1. Denkers E.Y., Badger C.C., Ledbetter J.A., and Bernstein I.D. Influence of antibody isotype on passive serotherapy of lymphoma. J. Immunol. 135 3 (1985) 2183-2186
2. Fan J., Liang X., Horton M.S., Perry H.C., Citron M.P., Heidecker G.J., Fu T.M., Joyce J., Przysiecki C.T., Keller P.M., Garsky V.M., Ionescu R., Rippeon Y., Shi L., Chastain M.A., Condra J.H., Davies M.E., Liao J., Emini E.A., and Shiver J.W. Preclinical study of influenza virus A M2 peptide conjugate vaccines in mice, ferrets, and rhesus monkeys. Vaccine 22 23-24 (2004) 2993-3003
3. Fischer W.B., and Sansom M.S. Viral ion channels: structure and function. Biochim. Biophys. Acta 1561 1 (2002) 27-45
4. Frace A.M., Klimov A.I., Rowe T., Black R.A., and Katz J.M. Modified M2 proteins produce heterotypic immunity against influenza A virus. Vaccine 17 18 (1999) 2237-2244
5. Harbury P.B., Zhang T., Kim P.S., and Alber T. A switch between two-, three-, and four-stranded coiled coils in GCN4 leucine zipper mutants. Science 262 5138 (1993) 1401-1407
6. Holsinger L.J., and Lamb R.A. Influenza virus M2 integral membrane protein is a homotetramer stabilized by formation of disulfide bonds. Virology 183 1 (1991) 32-43
7. Hughey P.G., Roberts P.C., Holsinger L.J., Zebedee S.L., Lamb R.A., and Compans R.W. Effects of antibody to the influenza A virus M2 protein on M2 surface expression and virus assembly. Virology 212 2 (1995) 411-421
8. Jegerlehner A., Schmitz N., Storni T., and Bachmann M.F. Influenza A vaccine based on the extracellular domain of M2: weak protection mediated via antibody-dependent NK cell activity. J. Immunol. 172 9 (2004) 5598-5605
9. Joyce J.G., Hurni W.M., Bogusky M.J., Garsky V.M., Liang X., Citron M.P., Danzeisen R.C., Miller M.D., Shiver J.W., and Keller P.M. Enhancement of alpha-helicity in the HIV-1 inhibitory peptide DP178 leads to an increased affinity for human monoclonal antibody 2F5 but does not elicit neutralizing responses in vitro. Implications for vaccine design. J. Biol. Chem. 277 48 (2002) 45811-45820
10. Lamb R.A., Zebedee S.L., and Richardson C.D. Influenza virus M2 protein is an integral membrane protein expressed on the infected-cell surface. Cell 40 3 (1985) 627-633
11. Liu W., and Chen Y.H. High epitope density in a single protein molecule significantly enhances antigenicity as well as immunogenicity: a novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins. Eur. J. Immunol. 35 2 (2005) 505-514
12. Liu W., Zou P., and Chen Y.H. Monoclonal antibodies recognizing EVETPIRN epitope of influenza A virus M2 protein could protect mice from lethal influenza A virus challenge. Immunol. Lett. 93 2-3 (2004) 131-136
13. Mozdzanowska K., Feng J., Eid M., Kragol G., Cudic M., Otvos Jr. L., and Gerhard W. Induction of influenza type A virus-specific resistance by immunization of mice with a synthetic multiple antigenic peptide vaccine that contains ectodomains of matrix protein 2. Vaccine 21 19-20 (2003) 2616-2626
14. Neirynck S., Deroo T., Saelens X., Vanlandschoot P., Jou W.M., and Fiers W. A universal influenza A vaccine based on the extracellular domain of the M2 protein. Nat. Med. 5 10 (1999) 1157-1163
15. Okuda K., Ihata A., Watabe S., Okada E., Yamakawa T., Hamajima K., Yang J., Ishii N., Nakazawa M., Ohnari K., Nakajima K., and Xin K.Q. Protective immunity against influenza A virus induced by immunization with DNA plasmid containing influenza M gene. Vaccine 19 27 (2001) 3681-3691
16. Pinto L.H., Holsinger L.J., and Lamb R.A. Influenza virus M2 protein has ion channel activity. Cell 69 3 (1992) 517-528
17. Pinto L.H., Dieckmann G.R., Gandhi C.S., Papworth C.G., Braman J., Shaughnessy M.A., Lear J.D., Lamb R.A., and DeGrado W.F. A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity. Proc. Natl. Acad. Sci. U.S.A. 94 21 (1997) 11301-11306
18. Schnell J.R., and Chou J.J. Structure and mechanism of the M2 proton channel of influenza A virus. Nature 451 7178 (2008) 591-595
19. Seaman W.E., Sleisenger M., Eriksson E., and Koo G.C. Depletion of natural killer cells in mice by monoclonal antibody to NK-1.1. Reduction in host defense against malignancy without loss of cellular or humoral immunity. J. Immunol. 138 12 (1987) 4539-4544
20. Slepushkin V.A., Katz J.M., Black R.A., Gamble W.C., Rota P.A., and Cox N.J. Protection of mice against influenza A virus challenge by vaccination with baculovirus-expressed M2 protein. Vaccine 13 15 (1995) 1399-1402
21. Stouffer A.L., Acharya R., Salom D., Levine A.S., Di Costanzo L., Soto C.S., Tereshko V., Nanda V., Stayrook S., and DeGrado W.F. Structural basis for the function and inhibition of an influenza virus proton channel. Nature 451 7178 (2008) 596-599
22. Takeda M., Pekosz A., Shuck K., Pinto L.H., and Lamb R.A. Influenza A virus M2 ion channel activity is essential for efficient replication in tissue culture. J. Virol. 76 3 (2002) 1391-1399
23. Tang Y., Zaitseva F., Lamb R.A., and Pinto L.H. The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue. J. Biol. Chem. 277 42 (2002) 39880-39886
24. Tian C., Gao P.F., Pinto L.H., Lamb R.A., and Cross T.A. Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers. Protein Sci. 12 11 (2003) 2597-2605
25. Treanor J.J., Tierney E.L., Zebedee S.L., Lamb R.A., and Murphy B.R. Passively transferred monoclonal antibody to the M2 protein inhibits influenza A virus replication in mice. J. Virol. 64 3 (1990) 1375-1377
26. Watanabe T., Watanabe S., Ito H., Kida H., and Kawaoka Y. Influenza A virus can undergo multiple cycles of replication without M2 ion channel activity. J. Virol. 75 12 (2001) 5656-5662
27. Yokoyama W. Production of monoclonal antibodies. In: Coligan J., Kruisbeek A., Margulies D., Shevach E., and Strober W. (Eds). Current Protocols in Immunology (2003), John Wiley & Sons, Inc.
28. Zebedee S.L., and Lamb R.A. Influenza A virus M2 protein: monoclonal antibody restriction of virus growth and detection of M2 in virions. J. Virol. 62 8 (1988) 2762-2772
29. Zebedee S.L., and Lamb R.A. Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein. Proc. Natl. Acad. Sci. U.S.A. 86 3 (1989) 1061-1065
30. Zharikova D., Mozdzanowska K., Feng J., Zhang M., and Gerhard W. Influenza type A virus escape mutants emerge in vivo in the presence of antibodies to the ectodomain of matrix protein 2. J. Virol. 79 11 (2005) 6644-6654