Quality assessment of recombinant proteins produced in plants

Methods in Molecular Biology

Volumn 824, Issue , 2012, Pages 535-564

  Medrano, Giuliana ^a   Dolan, Maureen C ^a,b   Condori, Jose ^a   Radin, David N ^c   Cramer, Carole L ^a  

^a ARKANSAS STATE UNIVERSITY   (United States)

^b Applied Food Technologies Inc   (United States)

^c BioStrategies LC   (United States)

Author keywords

Bioactivity; ELISA; Endotoxin; HIS tag; Interleukin 12; MS MALDI; Plant based bioproduction; Product validation; Recombinant protein; Western analyses

Indexed keywords

INTERLEUKIN 12; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; BIOREACTOR; BIOSYNTHESIS; BIOTECHNOLOGY; CHICKEN; ENZYME LINKED IMMUNOSORBENT ASSAY; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; PLANT LEAF; POLYACRYLAMIDE GEL ELECTROPHORESIS; QUALITY CONTROL; STANDARD; TOBACCO; WESTERN BLOTTING;

ANIMALS; BIOREACTORS; BIOTECHNOLOGY; BLOTTING, WESTERN; CHICKENS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; INTERLEUKIN-12; PLANT LEAVES; QUALITY CONTROL; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TOBACCO;

ANIMALIA; AVES; NICOTIANA BENTHAMIANA;

EID: 84855938036     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-433-9_29     Document Type: Article

References (21)

1. Liu C, Towler M, Medrano G, et al (2009) Production of mouse interleukin-12 is greater in tobacco hairy roots grown in a mist reactor than in an airlift reactor. Biotechnol. Bioeng. 102, 1074-1086.
2. Medrano G, Reidy M, Liu J, et al (2009) Rapid system for evaluating bioproduction capacity of complex pharmaceutical proteins in plants. In: Faye L, and Gomord V (eds). Methods Mol Biol Humana Press, Totowa, NJ 483, 51-67.
3. Medrano G, Dolan MC, Stephens NT, et al (2010) Effi cient plant-based production of chicken interleukin-12 yields a strong immunostimulatory cytokine. J. Interferon Cytokine Res. 30, 143-154.
4. Condori J, Medrano G, Sivakumar G, et al (2009) Functional characterization of a stilbene synthase gene using a transient expression system in planta. Plant Cell Rep. 28, 589-599.
5. Cramer CL, Boothe JG, Oishi KK (1999) Transgenic plants for therapeutic proteins: linking upstream and downstream strategies. Curr. Top. Microbiol. Immunol. 240, 95-118. (Pubitemid 29202401)
6. Cramer CL, Weissenborn DL, Oishi KK, et al (1996) Bioproduction of human enzymes in transgenic tobacco. Ann. N.Y. Acad. Sci. 792, 62-71. (Pubitemid 26267837)
7. Liu J, Dolan MC, Reidy M, et al (2008) Expression of bioactive single-chain murine IL-12 in transgenic plants. J. Interferon Cytokine Res. 28, 381-392.
8. Daniell H, Singh ND, Mason H, et al (2009) Plant-made vaccine antigens and biopharmaceuticals. Trends Plant Sci. 14, 669-679.
9. Tremblay R, Wang D, Jevnikar AM, et al (2010) Tobacco, a highly effi cient green bioreactor for production of therapeutic proteins. Biotechnol. Adv. 28, 214-221.
10. Wang DJ, Brandsma M, Yin Z, et al (2008) A novel platform for biologically active recombinant human interleukin-13 production. Plant Biotechnol. J. 6, 504-515. (Pubitemid 351670276)
11. Matoba N, Kajiura H, Cherni I, et al (2009) Biochemical and immunological characterization of the plant-derived candidate human immunodefi ciency virus type 1 mucosal vaccine CTB-MPR. Plant Biotechnol. J. 7, 129-145.
12. Conley AJ, Joensuu JJ, Menassa R, et al (2009) Induction of protein body formation in plant leaves by elastin-like polypeptide fusions. BMC Biol. 7, 48.
13. Alvarez ML, Topal E, Martin F, et al (2010) Higher accumulation of F1-V fusion recombinant protein in plants after induction of protein body formation. Plant Mol. Biol. 72, 75-89.
14. Hood EE, Bailey MR, Beifuss K, et al (2003) Criteria for high-level expression of a fungal laccase gene in transgenic maize. Plant Biotechnol. J. 1, 129-140.
15. Torrent M, Llompart B, Lasserre-Ramassamy S, et al (2009) Eukaryotic protein production in designed storage organelles. BMC Biol. 7, 5.
16. Schillberg S, Twyman RM, Fischer R (2005) Opportunities for recombinant antigen and antibody expression in transgenic plants-technology assessment. Vaccine 23, 1764-1769. (Pubitemid 40331841)
17. Reed DG, Nopo-Olazabal LH, Funk V, et al (2005) Expression of functional hexahistidinetagged ricin B in tobacco. Plant Cell Rep. 24, 15-24. (Pubitemid 40534186)
18. Hood E, Cramer CL, Medrano G, et al (2012) Protein targeting: strategic planning for optimizing protein products through plant biotechnology. In: Altman A, Hasegawa PM (eds). Plant Biotechnology and Agriculture: Prospects for the 21st Century. San Diego, CA: Elsevier Inc. doi: 10.1016/B978-0-12- 381466-1.00003-1.
19. Lambrecht B, Gonze M, Meulemans G, et al (2000) Production of antibodies against chicken interferon-gamma: demonstration of neutralizing activity and development of a quantitative ELISA. Vet. Immunol. Immunopathol. 74, 137-144. (Pubitemid 30173175)
20. Shaaltiel Y, Bartfeld D, Hashmueli S, et al (2007) Production of glucocerebrosidase with terminal mannose glycans for enzyme replacement therapy of Gaucher's disease using a plant cell system. Plant Biotechnol. J. 5, 579-590. (Pubitemid 47196361)
21. Jeoh T, Michener W, Himmel ME, et al (2008) Implications of cellobiohydrolase glycosylation for use in biomass conversion. Biotechnol. Biofuels 1, 10.