Neovascularization: Ocular diseases, animal models and therapies

Advances in Experimental Medicine and Biology

Volumn 723, Issue , 2012, Pages 245-252

  Cai, Xue ^a   Sezate, Steven A ^a   McGinnis, James F ^a,b  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

Author keywords

Age Related Macular Degeneration; Animal Models; CNV; Diabetic Retinopathy; Nanoceria; Nanoparticles; Neovascularization; Ocular Diseases; PEDF; Reactive Oxygen Species; Retinopathy Of Prematurity; RNV; VEGF; Vldlr

Indexed keywords

5 AMINO 1 [3,5 DICHLORO 4 (4 CHLOROBENZOYL)BENZYL] 1H 1,2,3 TRIAZOLE 4 CARBOXAMIDE; ADENOVIRUS VECTOR; ANGIOGENESIS INHIBITOR; CERIUM OXIDE NANOPARTICLE; DICKKOPF 1 PROTEIN; K 252A; LODAMIN; MONOCLONAL ANTIBODY; NANOPARTICLE; PARVOVIRUS VECTOR; SONEPCIZUMAB; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

ANIMAL MODEL; BLINDNESS; CONFERENCE PAPER; DIABETIC RETINOPATHY; DISEASE COURSE; DRUG MECHANISM; ENVIRONMENTAL FACTOR; GENE; GENE MUTATION; INSULIN 2 GENE; NANOMEDICINE; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; OXYGENN INDUCED RETINOPATHY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGENERATIVE MEDICINE; RETINA MACULA AGE RELATED DEGENERATION; RETINA NEOVASCULARIZATION; RETROLENTAL FIBROPLASIA; STEM CELL TRANSPLANTATION; SUBRETINAL NEOVASCULARIZATION; VERY LOW DENSITY LIPOPROTEIN RECEPTOR GENE;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; NANOMEDICINE; NEOVASCULARIZATION, PATHOLOGIC; RETINAL DISEASES;

ANIMALIA;

EID: 84855932319     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-0631-0_32     Document Type: Conference Paper

References (34)

1. Afzal A, Caballero S, Palii SS et al (2010) Targeting retinal and choroid eovascularization using the small molecule inhibitor carboxyamidotriazole. Brain Res Bull 81: 320-326
2. Barber AJ, Antonetti DA, Kern TS et al (2005) The Ins2Akita mouse as a model of ear ly retinal complications in diabetes. Invest Ophthalmol Vis Sci 46: 2210-2218
3. Benny O, Nakai K, Yoshimura T et al (2010) Broad spectrum antiangiogenic treatment for ocular neovascular diseases. PLoS One 5 pII: e12515
4. Bird AC (2010) Therapeutic targets in age-related macular disease. J Clin Invest 120: 3033-3041
5. Chen J, Patil S, Seal S et al (2006) Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides. Nat Nanotechnol 1: 142-150
6. Chen Y, Hu Y, Zhou T et al (2009) Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models. Am J Pathol 175: 2676-2685
7. Cheung N, Mitchell P, Wong TY (2010) Diabetic retinopathy. Lancet 376: 124-136
8. Dorrell MI, Aguilar E, Jacobson R et al (2009) Antioxidant or neurotrophic factor treatment preserves function in a mouse model of neovascularization-associated oxidative stress. J Clin Invest 119: 611-623
9. Edwards AO, Malek G (2007) Molecular genetics of AMD and current animal models. Angiogenesis 10: 119-132 (Pubitemid 46440627)
10. Ellis-Behnke R, Jonas JB (2011) Redefi ning tissue engineering for nanomedicine in ophthalmology. Acta Ophthalmol e108-e114
11. Friedlander M (2009) Combination angiostatic therapies: targeting multiple angiogenic pathways. Retina 29: S27-29
12. Gibson DL, Sheps SB, Schechter MT et al (1989) Retinopathy of prematurity: a new epidemic? Pediatrics 83: 486-492 (Pubitemid 19092577)
13. Grossniklaus HE, Kang SJ, Berglin L (2010) Animal models of choroidal and retinal neovascularization. Prog Retin Eye Res 29: 500-519
14. Hu W, Jiang A, Liang J et al (2008) Expression of VLDLR in the retina and evolution of subretinal neovascularization in the knockout mouse model's retinal angiomatous proliferation. Invest Ophthalmol Vis Sci 49: 407-415
15. Jiang J, Xia XB, Xu HZ et al (2009) Inhibition of retinal neovascularization by gene transfer of small interfering RNA targeting HIF-1alpha and VEGF. J Cell Physiol 218: 66-74
16. Lai CM, Dunlop SA, May LA et al (2005a) Generation of transgenic mice with mild and severe retinal neovascularisation. Br J Ophthalmol 89: 911-916 (Pubitemid 40904820)
17. Lai CM, Shen WY, Brankov M et al (2005b) Long-term evaluation of AAV-mediated sFlt-1 gene therapy for ocular neovascularization in mice and monkeys. Mol Ther 12: 659-668 (Pubitemid 41350147)
18. Lamartina S, Cimino M, Roscilli G et al (2007) Helper-dependent adenovirus for the gene therapy of proliferative retinopathies: stable gene transfer, regulated gene expression and therapeutic effi cacy. J Gene Med 9: 862-874 (Pubitemid 47543253)
19. Limae Silva R, Shen J, Gong YY et al (2010) Agents that bind annexin A2 suppress ocular neovascularization. J Cell Physiol 225: 855-864
20. Liu X, Wang D, Liu Y et al (2010) Neuronal-driven angiogenesis: role of NGF in retinal neovascularization in an oxygen-induced retinopathy model. Invest Ophthalmol Vis Sci 51: 3749-3757
21. Marchetti V, Krohne TU, Friedlander DF et al (2010) Stemming vision loss with stem cells. J Clin Invest 120: 3012-3021
22. Ohno-Matsui K, Hirose A, Yamamoto S et al (2002) Inducible expression of vascular endothelial growth factor in adult mice causes severe proliferative retinopathy and retinal detachment. Am J Pathol 160: 711-719 (Pubitemid 34160349)
23. Otani A, Kinder K, Ewalt K et al (2002) Bone marrow-derived stem cells target retinal astrocytes and can promote or inhibit retinal angiogenesis. Nat Med 8: 1004-1010 (Pubitemid 35033705)
24. Pechan P, Rubin H, Lukason M et al (2009) Novel anti-VEGF chimeric molecules delivered by AAV vectors for inhibition of retinal neovascularization. Gene Ther 16: 10-16
25. Ricci B (1990) Oxygen-induced retinopathy in the rat model. Doc Ophthalmol 74: 171-177 (Pubitemid 20275850)
26. Ritter MR, Banin E, Moreno SK et al (2006) Myeloid progenitors differentiate into microglia and promote vascular repair in a model of ischemic retinopathy. J Clin Invest 116: 3266-3276 (Pubitemid 44878641)
27. Rokoczy E, Rashman I, Binz N et al (2010) Characterization of a mouse model of hyperglycemia and retinal neovascularization. Am J Pathol 177
28. Sapieha P, Joyal JS, Rivera JC et al (2010) Retinopathy of prematurity: understanding ischemic retinal vasculopathies at an extreme of life. J Clin Invest 120: 3022-3032
29. Singh S, Kumar A, Karakoti A, et al. (2010) Unveiling the mechanism of uptake and sub-cellular distribution of cerium oxide nanoparticles. Mol Biosyst 6: 1813-1820
30. Takeda A, Baffi JZ, Kleinman ME et al (2009) CCR3 is a target for age-related macular degeneration diagnosis and therapy. Nature 460: 225-230
31. Tobe T, Ortega S, Luna JD et al (1998) Targeted disruption of the FGF2 gene does not prevent choroidal neovascularization in a murine model. Am J Pathol 153: 1641-1646 (Pubitemid 28509922)
32. Xie B, Shen J, Dong A et al (2009) Blockade of sphingosine-1-phosphate reduces macrophage infl ux and retinal and choroidal neovascularization. J Cell Physiol 218: 192-198
33. Xiong SQ, Xia XB, Xu HZ et al (2009) Suppression of retinal neovascularization by smallinterference RNA targeting erythropoietin. Ophthalmologica 223: 306-312
34. Yoshioka M, Kayo T, Ikeda T et al (1997) A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46: 887-894 (Pubitemid 27188269)