Albendazole versus metronidazole in the treatment of adult giardiasis: A randomized, double-blind, clinical trial

Current Medical Research and Opinion

Volumn 28, Issue 1, 2012, Pages 149-154

  Cañete, Roberto ^a,b   Rodrguez, Pablo ^b   Mesa, Lumey ^b   Brito, Katia ^c   Prior, Ada ^b   Guilhem, Dirce ^d   Novaes, M R C G ^d  

^a INSTITUTO DE GASTROENTEROLOGÍA   (Cuba)

^b INSTITUTO NACIONAL DE HIGIENE   (Cuba)

^c Ministry of Health   (Cuba)

^d UNIVERSITY OF BRASILIA   (Brazil)

Author keywords

Albendazole; Benzimidazoles; Giardia duodenalis; Metronidazole

Indexed keywords

ALBENDAZOLE; METRONIDAZOLE;

ABDOMINAL PAIN; ADULT; ARTICLE; BITTER TASTE; COMPARATIVE STUDY; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; FECES CULTURE; FEMALE; FOLLOW UP; GIARDIA DUODENALIS; GIARDIASIS; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; NONHUMAN; PATIENT COMPLIANCE; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; TREATMENT DURATION; TREATMENT RESPONSE; URINE COLOR; VOMITING;

ADULT; AGE OF ONSET; ALBENDAZOLE; ANTIPROTOZOAL AGENTS; CUBA; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; GIARDIASIS; HUMANS; METRONIDAZOLE; TREATMENT OUTCOME;

EID: 84855916246     PISSN: 03007995     EISSN: 14734877     Source Type: Journal    
DOI: 10.1185/03007995.2011.637915     Document Type: Article

References (37)

1. Escobedo AA, Cañete R, Nú ñ ez FA. Risk factors and clinical features associated with intestinal parasitic infections in children from San Juan y Martínez, Pinar del Río, Cuba. West Indian Med J 2008;57:377-82
2. Solaymani-Mohammadi S, Genkinger JM, Loffredo CA, et al. A meta-analysis of the effectiveness of albendazole compared with metronidazole as treatments for infections with giardia duodenalis. PLoS Negl Trop Dis 2010;4:e682. doi:10.1371/journal.pntd.0000682
3. Savioli L, Smith H, Thompson A. Giardia and Cryptosporidium join the "Neglected Diseases Initiative". Trends Parasitol 2006;22:203-8
4. Lalle M. Giardiasis in the post genomic era: treatment, drug resistance and novel therapeutic perspectives. Infect Disord Drug Targets 2010;10: 283-94
5. Plutzer J, Ongerth J, Karanis P. Giardia taxonomy, phylogeny and epidemiology: facts and open questions. Int J Hyg Environ Health 2010;213:321-33
6. Carranza PG, Lujan HD. New insights regarding the biology of Giardia lamblia. Microbes Infect 2010;12:71-80
7. Cañete R, González ME, Almirall P, et al. Infecció n por giardia y giardiosis. Rev Panam Infectol 2004;6:39-46
8. Escobedo AA, Cimerman S. Giardiasis: a pharmacotherapy. Expert Opin Pharmacother 2007;8:1885-902
9. Cañete R, Escobedo AA, Almirall P, et al. Mebendazole in parasitic infections other than those caused by soil-transmitted helminths. Trans R Soc Trop Med Hyg 2009;103:437-42
10. Tian HF, Chen B, Wen JF. Giardiasis, drug resistance, and new target discovery. Infect Disord Drug Targets 2010;10:295-302
11. Mü ller J, Wastling J, Sanderson S, et al. A novel Giardia lamblia nitroreductase, GlNR1, interacts with nitazoxanide and other thiazolides. Antimicrob Agents Chemother 2007;51:1979-86 (Pubitemid 46903083)
12. Hausen MA, de Oliveira RP, Gadelha AP, et al. Giardia lamblia: a report of drug effects under cell differentiation. Parasitol Res 2009;105:789-96
13. Keiser J, Utzinger J. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 2008;299:1937-48 (Pubitemid 351574924)
14. Geary TG, Woo K, McCarthy JS, et al. Unresolved issues in anthelmintic pharmacology for helminthiases of humans. Int J Parasitol 2010;40:1-13
15. Uneke CJ. Soil transmitted helminth infections and schistosomiasis in school age children in sub-Saharan Africa: efficacy of chemotherapeutic intervention since World Health Assembly Resolution 2001. Tanzan J Health Res 2010;12:86-99
16. Sudomo M, Chayabejara S, Duong S, et al. Elimination of lymphatic filariasis in Southeast Asia. Adv Parasitol 2010;72:205-33
17. Tian HF, Chen B, Wen JF. Giardiasis, drug resistance, and new target discovery. Infect Disord Drug Targets. 2010;10:295-302
18. Cedillo-Rivera R, Muñoz O. In vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents. J Med Microbiol 1992;37:221-4
19. Katiyar SK, Gordon VR, McLaughlin GL, et al. Antiprotozoal activities of benzimidazoles and correlations with beta-tubulin sequence. Antimicrob Agents Chemother 1994;38:2086-90 (Pubitemid 24278805)
20. Chávez B, Cedillo-Rivera R, Martínez-Palomo A. Giardia lamblia: ultrastructural study of the in-vitro effect of benzimidazoles. J Parasitol 1992;39:510-15
21. Morgan UM, Reynoldson JA, Thompson RC. Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro. Antimicrob Agents Chemother 1993;37:328-31 (Pubitemid 23046578)
22. Katelaris PH, Naeem A, Farthing MJ. Activity of metronidazole, azithromycin and three benzimidazoles on Giardia lamblia growth and attachment to a human intestinal cell line. Aliment Pharmacol Ther 1994;8:187-92 (Pubitemid 24220595)
23. Reynoldson JA, Thompson RC, Meloni BP. In vivo efficacy of albendazole against Giardia duodenalis in mice. Parasitol Res 1991;77:325-28
24. Morch K, Hanevik K, Rortveit G, et al. High rate of fatigue and abdominal symptoms 2 years after an outbreak of giardiasis. Trans R Soc Trop Med Hyg 2009;103:530-2
25. Morken MH, Valeur J, Norin E, et al. Antibiotic or bacterial therapy in post-giardiasis irritable bowel syndrome. Scand J Gastroenterol 2009;44: 1296-303
26. Cañete R, Rivas DE, Escobedo AA, et al. A randomized, controlled, open-label trial evaluating the efficacy and safety of chloroquine in the treatment of giardiasis in children. West Indian Med J 2010;59:607-11
27. Gonzá lez ME, Cañete R, Á lvarez G, et al. Nitazoxanide for the treatment of Giardia duodenalis infection: a comparative trial with secnidazole. Tü rk Hijyen ve Deneysel Biyoloji Dergisi 2010;67(3):113-9
28. Cañete R, Escobedo AA, Gonzá lez ME, et al. A randomised, controlled, openlabel trial of a single day of mebendazole versus a single dose of tinidazole in the treatment of giadiasis in children. Curr Med Res Opin 2006;22:2131-6
29. Cañete R, Escobedo AA, Gonzá lez ME, et al. Randomized clinical study of five days therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children. World J Gastroenterol 2006;12:6366-70
30. Escobedo AA, Cañete R, Gonzá lez ME, et al. A randomized trial comparing mebendazole and secnidazole for the treatment of giardiasis. Ann Trop Med Parasitol 2003;97:499-504 (Pubitemid 36898086)
31. Alizadeh A, Ranjbar M, Kashani KM, et al. Albendazole versus metronidazole in the treatment of patients with giardiasis in the Islamic Republic of Iran. East Mediterr Health J 2006;12:548-54 (Pubitemid 46358303)
32. Karabay O, Tamer A, Gunduz H, et al. Albendazole versus metronidazole treatment of adult giardiasis: an open randomized clinical study. World J Gastroenterol 2004;10:1215-17 (Pubitemid 38559403)
33. Yereli K, Balcioglu IC, Ertan P, et al. Albendazole as an alternative therapeutic agent for childhood giardiasis in Turkey. Clin Microbiol Infect 2004;10:527-9 (Pubitemid 38961577)
34. Misra PK, Kumar A, Agarwal V, et al. A comparative clinical trial of albendazole versus metronidazole in children with giardiasis. Indian Pediat 1995;32:779-82
35. Hall A, Nahar Q. Albendazole as a treatment for infections with Giardia duodenalis in children in Bangladesh. Trans R Soc Trop Med Hyg 1993;87:84-6
36. Romero-Cabello R, Robert L, Muñ oz-García R, et al. Randomized study comparing the safety and efficacy of albendazole and metronidazole in the treatment of giardiasis in children. Rev Latinoam Microbiol 1995;37:315-23 (Pubitemid 26126330)
37. Islamova ZhI, Syrov VN, Khushbaktova ZA, et al. The efficacy of ecdystene versus metronidazole in the treatment of lambliasis. Med Parazitol (Mosk) 2010;(2):14-7