Muscle time under tension during resistance exercise stimulates differential muscle protein sub-fractional synthetic responses in men

Journal of Physiology

Volumn 590, Issue 2, 2012, Pages 351-362

  Burd, Nicholas A ^a   Andrews, Richard J ^a   West, Daniel W D ^a   Little, Jonathan P ^a   Cochran, Andrew J R ^a   Hector, Amy J ^a   Cashaback, Joshua G A ^b   Gibala, Martin J ^a   Potvin, James R ^b   Baker, Steven K ^c   Phillips, Stuart M ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL PROTEIN; MUSCLE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHENYLALANINE;

ADULT; ARTICLE; BODY MASS; CONCENTRIC MUSCLE CONTRACTION; CONTROLLED STUDY; ECCENTRIC MUSCLE CONTRACTION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; KNEE FUNCTION; MALE; MUSCLE BIOPSY; MUSCLE EXCITATION; MUSCLE EXERCISE; MUSCLE MITOCHONDRION; MUSCLE STRENGTH; MUSCLE TONE; NEEDLE BIOPSY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RESISTANCE TRAINING; RESPONSE TIME; REST; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; VASTUS LATERALIS MUSCLE;

AMINO ACIDS; BIOPSY; BLOOD GLUCOSE; ELECTROMYOGRAPHY; EXERCISE; HUMANS; INSULIN; MALE; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SKELETAL; RESISTANCE TRAINING; TIME FACTORS; YOUNG ADULT;

EID: 84855902966     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2011.221200     Document Type: Article

References (34)

1. Atherton PJ, Etheridge T, Watt PW, Wilkinson D, Selby A, Rankin D, Smith K & Rennie MJ (2010). Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling. Am J Clin Nutr 92, 1080-1088.
2. Burd NA, Holwerda AM, Selby KC, West DW, Staples AW, Cain NE, Cashaback JG, Potvin JR, Baker SK & Phillips SM (2010a). Resistance exercise volume affects myofibrillar protein synthesis and anabolic signalling molecule phosphorylation in young men. J Physiol 588, 3119-3130.
3. Burd NA, West DW, Moore DR, Atherton PJ, Staples AW, Prior T, Tang JE, Rennie MJ, Baker SK & Phillips SM (2011a). Enhanced amino acid sensitivity of myofibrillar protein synthesis persists for up to 24 h after resistance exercise in young men. J Nutr 141, 568-573.
4. Burd NA, West DW, Rerecich T, Prior T, Baker SK & Phillips SM (2011b). Validation of a single biopsy approach and bolus protein feeding to determine myofibrillar protein synthesis in stable isotope tracer studies in humans. Nutr Metab (Lond) 8, 15.
5. Burd NA, West DW, Staples AW, Atherton PJ, Baker JM, Moore DR, Holwerda AM, Parise G, Rennie MJ, Baker SK & Phillips SM (2010b). Low-load high volume resistance exercise stimulates muscle protein synthesis more than high-load low volume resistance exercise in young men. PLoS One 5, e12033.
6. Camera DM, Edge J, Short MJ, Hawley JA & Coffey VG (2010). Early time course of Akt phosphorylation after endurance and resistance exercise. Med Sci Sports Exerc 42, 1843-1852.
7. Chesley A, MacDougall JD, Tarnopolsky MA, Atkinson SA & Smith K (1992). Changes in human muscle protein synthesis after resistance exercise. J Appl Physiol 73, 1383-1388.
8. Cochran AJ, Little JP, Tarnopolsky MA & Gibala MJ (2010). Carbohydrate feeding during recovery alters the skeletal muscle metabolic response to repeated sessions of high-intensity interval exercise in humans. J Appl Physiol 108, 628-636.
9. Dreyer HC, Fujita S, Cadenas JG, Chinkes DL, Volpi E & Rasmussen BB (2006). Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol 576, 613-624.
10. Egan B, Carson BP, Garcia-Roves PM, Chibalin AV, Sarsfield FM, Barron N, McCaffrey N, Moyna NM, Zierath JR & O'Gorman DJ (2010). Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signalling kinases in human skeletal muscle. J Physiol 588, 1779-1790.
11. Fuglevand AJ, Zackowski KM, Huey KA & Enoka RM (1993). Impairment of neuromuscular propagation during human fatiguing contractions at submaximal forces. J Physiol 460, 549-572.
12. Fujita S, Dreyer HC, Drummond MJ, Glynn EL, Cadenas JG, Yoshizawa F, Volpi E & Rasmussen BB (2007a). Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol 582, 813-823.
13. Fujita S, Rasmussen BB, Cadenas JG, Drummond MJ, Glynn EL, Sattler FR & Volpi E (2007b). Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling. Diabetes 56, 1615-1622.
14. Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ & Hargreaves M (2009). Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1α in human skeletal muscle. J Appl Physiol 106, 929-934.
15. Glover EI, Phillips SM, Oates BR, Tang JE, Tarnopolsky MA, Selby A, Smith K & Rennie MJ (2008). Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion. J Physiol 586, 6049-6061.
16. Henneman E, Somjen G & Carpenter DO (1965). Functional significance of cell size in spinal motoneurons. J Neurophysiol 28, 560-580.
17. Kumar V, Selby A, Rankin D, Patel R, Atherton P, Hildebrandt W, Williams J, Smith K, Seynnes O, Hiscock N & Rennie MJ (2009). Age-related differences in the dose-response relationship of muscle protein synthesis to resistance exercise in young and old men. J Physiol 587, 211-217.
18. T) method. Methods 25, 402-408.
19. Moore DR, Atherton PJ, Rennie MJ, Tarnopolsky MA & Phillips SM (2011). Resistance exercise enhances mTOR and MAPK signalling in human muscle over that seen at rest after bolus protein ingestion. Acta Physiol (Oxf) 201, 365-372.
20. Moore DR, Phillips SM, Babraj JA, Smith K & Rennie MJ (2005). Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. Am J Physiol Endocrinol Metab 288, E1153-E1159.
21. Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, Prior T, Tarnopolsky MA & Phillips SM (2009a). Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. Am J Clin Nutr 89, 161-168.
22. Moore DR, Tang JE, Burd NA, Rerecich T, Tarnopolsky MA & Phillips SM (2009b). Differential stimulation of myofibrillar and sarcoplasmic protein synthesis with protein ingestion at rest and after resistance exercise. J Physiol 587, 897-904.
23. Phillips SM, Tipton KD, Aarsland A, Wolf SE & Wolfe RR (1997). Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol Endocrinol Metab 273, E99-E107.
24. Ratamess NA, Alvar BA, Evetoch TK, Housh TJ, Kibler WB, Kraemer WJ & Triplett NT (2009). American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc 41, 687-708.
25. Rowlands DS, Thomson JS, Timmons BW, Raymond F, Fuerholz A, Mansourian R, Zwahlen MC, Metairon S, Glover E, Stellingwerff T, Kussmann M & Tarnopolsky MA (2011). Transcriptome and translational signaling following endurance exercise in trained skeletal muscle: impact of dietary protein. Physiol Genomics 43, 1004-1020.
26. Sale DG (1987). Influence of exercise and training on motor unit activation. Exerc Sport Sci Rev 15, 95-151.
27. Smith GI, Villareal DT, Lambert CP, Reeds DN, Mohammed BS & Mittendorfer B (2010). Timing of the initial muscle biopsy does not affect the measured muscle protein fractional synthesis rate during basal, postabsorptive conditions. J Appl Physiol 108, 363-368.
28. Tang JE, Hartman JW & Phillips SM (2006). Increased muscle oxidative potential following resistance training induced fibre hypertrophy in young men. Appl Physiol Nutr Metab 31, 495-501.
29. Tang JE, Perco JG, Moore DR, Wilkinson SB & Phillips SM (2008). Resistance training alters the response of fed state mixed muscle protein synthesis in young men. Am J Physiol Regul Integr Comp Physiol 294, R172-E178.
30. Terzis G, Spengos K, Mascher H, Georgiadis G, Manta P & Blomstrand E (2010). The degree of p70 S6k and S6 phosphorylation in human skeletal muscle in response to resistance exercise depends on the training volume. Eur J Appl Physiol 110, 835-843.
31. West DW, Burd NA, Coffey VG, Baker SK, Burke LM, Hawley JA, Moore DR, Stellingwerff T & Phillips SM (2011). Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. Am J Clin Nutr 94, 795-803.
32. West DW, Burd NA, Staples AW & Phillips SM (2010). Human exercise-mediated skeletal muscle hypertrophy is an intrinsic process. Int J Biochem Cell Biol 42, 1371-1375.
33. West DW, Kujbida GW, Moore DR, Atherton P, Burd NA, Padzik JP, De Lisio M, Tang JE, Parise G, Rennie MJ, Baker SK & Phillips SM (2009). Resistance exercise-induced increases in putative anabolic hormones do not enhance muscle protein synthesis or intracellular signalling in young men. J Physiol 587, 5239-5247.
34. Wilkinson SB, Phillips SM, Atherton PJ, Patel R, Yarasheski KE, Tarnopolsky MA & Rennie MJ (2008). Differential effects of resistance and endurance exercise in the fed state on signalling molecule phosphorylation and protein synthesis in human muscle. J Physiol 586, 3701-3717.