Pyrrole-based antitubulin agents: Two distinct binding modalities are predicted for C-2 analogues in the colchicine site

ACS Medicinal Chemistry Letters

Volumn 3, Issue 1, 2012, Pages 53-57

  Da, Chenxiao ^a   Telang, Nakul ^b   Barelli, Peter ^b   Jia, Xin ^b   Gupton, John T ^b   Mooberry, Susan L ^c   Kellogg, Glen E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF RICHMOND   (United States)

^c Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

Antitubulin; docking; hydropathic interactions; multifunctional pyrroles; structure activity relationship

Indexed keywords

3,5 DIBROMO 4 (3,4 DIMETHOXYPHENYL) 1H PYRROLE 2 CARBOXYLIC ACID ETHYL ESTER; COLCHICINE; ESTER DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING SITE; DRUG STRUCTURE; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR MODEL; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 84855890744     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml200217u     Document Type: Article

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