The non-independence of treatment outcomes from repeat IVF cycles: Estimates and consequences

Human Reproduction

Volumn 27, Issue 2, 2012, Pages 436-443

  Roberts, Stephen A ^a   Stylianou, Christos ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

embryo transfer; embryouterus model; heterogeneity; IVF; statistical models

Indexed keywords

ADULT; ARTICLE; BAYES THEOREM; CRYOPRESERVATION; EMBRYO TRANSFER; FEMALE; FERTILIZATION IN VITRO; HUMAN; MAJOR CLINICAL STUDY; PREDICTION; PREGNANCY OUTCOME; PROBABILITY; PROGNOSIS; TREATMENT OUTCOME; UTERUS;

EID: 84855887731     PISSN: 02681161     EISSN: 14602350     Source Type: Journal    
DOI: 10.1093/humrep/der420     Document Type: Article

References (22)

1. Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology. The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting. Hum Reprod 2011;26:1270-1283.
2. Baker VL, Luke B, Brown MB, Alvero R, Frattarelli JL, Usadi R, Grainger DA, Armstrong AY. Multivariate analysis of factors affecting probability of pregnancy and live birth with in vitro fertilization: an analysis of the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System. Fertil Steril 2010;94:1410-1416.
3. Brison DR, Houghton FD, Falconer D, Roberts SA, Hawkhead J, Humpherson PG, Lieberman BA, Leese HJ. Identification of viable embryos in IVF by non-invasive measurement of amino acid turnover. Hum Reprod 2004;19:2319-2324.
4. Cutting R, Morroll D, Roberts SA, Pickering S, Rutherford A. Elective single embryo transfer: guidelines for practice British Fertility Society and Association of Clinical Embryologists. Hum Fertil (Camb) 2008;11:131-146.
5. Dias S, McNamee R, Vail A. Bias in frequently reported analyses of subfertility trials. Stat Med 2008;27:5605-5619.
6. Hirst WM, Vail A, Brison DR, Roberts SA. Prognostic factors influencing fresh and frozen IVF outcomes: an analysis of the UK national database. Reprod BioMed Online 2011;22:437-448.
7. Jonsdottir I, Lundin K, Bergh C. Double embryo transfer gives good pregnancy and live birth rates in poor responders with a modest increase in multiple birth rates: results from an observational study. Acta Obstet Gynecol Scand 2011;90:761-766.
8. Katz-Jaffe MG, McReynolds S, Gardner DK, Schoolcraft WB. The role of proteomics in defining the human embryonic secretome. Mol Hum Reprod 2009;15:271-277.
9. Larsen K, Merlo J. Appropriate assessment of neighborhood effects on individual health: integrating random and fixed effects in multilevel logistic regression. Am J Epidemiol 2005;161:81-88.
10. Makubate B, Senn S. Planning and analysis of cross-over trials in infertility. Stat Med 2010;29:3203-3210.
11. Nelson SM, Lawlor DA. Predicting live birth, preterm delivery, and low birth weight in infants born from in vitro fertilisation: a prospective study of 144, 018 treatment cycles. PLoS Med 2011;8:e1000386.
12. Roberts SA. Models for assisted conception data with embryo-specific covariates. Stat Med 2007;26:156-170.
13. Roberts SA, Hirst WM, Brison DR, Vail A. Embryo and uterine influences on IVF outcomes: an analysis of a UK multi-centre cohort. Hum Reprod 2010a; 25:2792-2802.
14. Roberts SA, McGowan L, Hirst W, Brison D, Vail A, Lieberman B. Towards single embryo transfer? Modelling clinical outcomes of potential treatment choices using multiple data sources: predictive models and patient perspectives. Health Technol Assess 2010b; 14:1-237.
15. Roberts SA, McGowan L, Mark HW, Vail A, Rutherford A, Lieberman BA, Brison DR. Reducing the incidence of twins from IVF treatments: predictive modelling from a retrospective cohort. Hum Reprod 2011;26:569-575.
16. Seli E, Sakkas D, Scott R, Kwok SC, Rosendahl SM, Burns DH. Noninvasive metabolomic profiling of embryo culture media using Raman and near-infrared spectroscopy correlates with reproductive potential of embryos in women undergoing in vitro fertilization. Fertil Steril 2007;88:1350-1357.
17. Speirs AL, Lopata A, Gronow MJ, Kellow GN, Johnston WIH. Analysis of the benefits and risks of multiple embryo transfer. Fertil Steril 1983;39:468-471.
18. Steer CV, Mills CL, Tan SL, Campbell S, Edwards RG. The cumulative embryo score: a predictive embryo scoring technique to select the optimal number of embryos to transfer in an in-vitro fertilization and embryo transfer programme. Hum Reprod 1992;7:117-119.
19. Stylianou C. Predictive modelling of assisted conception data with embryo-level covariates. Statistical issues and application. Ph. D. Thesis. UK: University of Manchester, 2011.
20. Templeton A, Morris JK, Parslow W. Factors that affect outcome of in-vitro fertilisation treatment. Lancet 1996;348:1402-1406.
21. Vail A, Gardener E. Common statistical errors in the design and analysis of subfertility trials. Hum Reprod 2003;18:1000-1004.
22. Zhou H, Weinberg CR. Evaluating effects of exposures on embryo viability and uterine receptivity in in vitro fertilization. Stat Med 1998;17:1601-1612.