The prrAB two-component system is essential for Mycobacterium tuberculosis viability and is induced under nitrogen-limiting conditions

Journal of Bacteriology

Volumn 194, Issue 2, 2012, Pages 354-361

  Haydel, Shelley E ^a,b   Malhotra, Vandana ^a   Cornelison, Garrett L ^a   Clark Curtiss, Josephine E ^a,b  

^a ARIZONA STATE UNIVERSITY   (United States)

^b ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CARBON; NITROGEN; PRRA PROTEIN; PRRB PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL STRAIN; BACTERIAL VIABILITY; CARBON SOURCE; CONTROLLED STUDY; ENVIRONMENTAL STRESS; GENE DELETION; GENE INSERTION SEQUENCE; GENE LOCUS; GENETIC TRANSCRIPTION; HYPOXIA; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPERON; PH; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSPOSON;

BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MUTATION; MYCOBACTERIUM TUBERCULOSIS; NITROGEN; OPERON; OXYGEN CONSUMPTION; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; VIRULENCE;

MURINAE; MYCOBACTERIUM TUBERCULOSIS;

EID: 84855885889     PISSN: 00219193     EISSN: 10985530     Source Type: Journal    
DOI: 10.1128/JB.06258-11     Document Type: Article

References (32)

1. Albers E, Larsson C, Andlid T, Walsh MC, Gustafsson L. 2007. Effect of nutrient starvation on the cellular composition and metabolic capacity of Saccharomyces cerevisiae. Appl. Environ. Microbiol. 73:4839-4848.
2. Amon J, et al. 2008. Nitrogen control in Mycobacterium smegmatis: nitrogen-dependent expression of ammonium transport and assimilation proteins depends on the OmpR-type regulator GlnR. J. Bacteriol. 190:7108-7116.
3. Barbieri CM, Mack TR, Robinson VL, Miller MT, Stock AM. 2010. Regulation of response regulator autophosphorylation through interdomain contacts. J. Biol. Chem. 285:32325-32335.
4. Bardarov S, et al. 2002. Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis. Microbiology 148:3007-3017.
5. Betts JC, Lukey PT, Robb LC, McAdam RA, Duncan K. 2002. Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol. Microbiol. 43:717-731.
6. Converse PJ, et al. 2009. Role of the dosR-dosS two-component regulatory system in Mycobacterium tuberculosis virulence in three animal models. Infect. Immun. 77:1230-1237.
7. Ewann F, et al. 2002. Transient requirement of the PrrA-PrrB twocomponent system for early intracellular multiplication of Mycobacterium tuberculosis. Infect. Immun. 70:2256-2263.
8. Ewann F, Locht C, Supply P. 2004. Intracellular autoregulation of the Mycobacterium tuberculosis PrrA response regulator. Microbiology 150:241-246.
9. Fol M, et al. 2006. Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator. Mol. Microbiol. 60:643-657.
10. Friedland N, et al. 2007. Domain orientation in the inactive response regulator Mycobacterium tuberculosis MtrA provides a barrier to activation. Biochemistry 46:6733-6743.
11. Gao R, Mack TR, Stock AM. 2007. Bacterial response regulators: versatile regulatory strategies from common domains. Trends Biochem. Sci. 32:225-234.
12. Graham JE, Clark-Curtiss JE. 1999. Identification of Mycobacterium tuberculosis RNAs synthesized in response to phagocytosis by human macrophages by selective capture of transcribed sequences (SCOTS). Proc. Natl. Acad. Sci. U. S. A. 96:11554-11559.
13. Harth G, Horwitz MA. 1999. An inhibitor of exported Mycobacterium tuberculosis glutamine synthetase selectively blocks the growth of pathogenic mycobacteria in axenic culture and in human monocytes: extracellular proteins as potential novel drug targets. J. Exp. Med. 189:1425-1436.
14. Haydel SE. 2010. Extensively drug-resistant tuberculosis: a sign of the times and an impetus for antimicrobial discovery. Pharmaceuticals (Basel) 3:2268-2290.
15. Haydel SE, Clark-Curtiss JE. 2004. Global expression analysis of twocomponent system regulator genes during Mycobacterium tuberculosis growth in human macrophages. FEMS Microbiol. Lett. 236:341-347.
16. Haydel SE, Clark-Curtiss JE. 2006. The Mycobacterium tuberculosis TrcR response regulator represses transcription of the intracellularly expressed Rv1057 gene, encoding a seven-bladed β-propeller. J. Bacteriol. 188:150-159.
17. Haydel SE, Dunlap NE, Benjamin WH, Jr. 1999. In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins. Microb. Pathog. 26:195-206.
18. Khan A, Akhtar S, Ahmad JN, Sarkar D. 2008. Presence of a functional nitrate assimilation pathway in Mycobacterium smegmatis. Microb. Pathog. 44:71-77.
19. Malhotra V, et al. 2004. Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. FEMS Microbiol. Lett. 231:237-245.
20. Malhotra V, Tyagi JS, Clark-Curtiss JE. 2009. DevR-mediated adaptive response in Mycobacterium tuberculosis H37Ra: links to asparagine metabolism. Tuberculosis 89:169-174.
21. Manning JM, Moore S, Rowe WB, Meister A. 1969. Identification of L-methionine S-sulfoximine as the diastereoisomer of L-methionine SR sulfoximine that inhibits glutamine synthetase. Biochemistry 8:2681-2685.
22. Nowak E, Panjikar S, Konarev P, Svergun DI, Tucker PA. 2006. The structural basis of signal transduction for the response regulator PrrA from Mycobacterium tuberculosis. J. Biol. Chem. 281:9659-9666.
23. Pérez E, et al. 2001. An essential role for phoP in Mycobacterium tuberculosis virulence. Mol. Microbiol. 41:179-187.
24. Saini DK, et al. 2004. DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR. Microbiology 150:865-875.
25. Sassetti CM, Boyd DH, Rubin EJ. 2003. Genes required for mycobacterial growth defined by high density mutagenesis. Mol. Microbiol. 48:77-84.
26. Stover CK, et al. 1991. New use of BCG for recombinant vaccines. Nature 351:456-460.
27. Tullius MV, Harth G, Horwitz MA. 2003. Glutamine synthetase GlnA1 is essential for growth of Mycobacterium tuberculosis in human THP-1 macrophages and guinea pigs. Infect. Immun. 71:3927-3936.
28. Tyagi JS, Sharma D. 2004. Signal transduction systems of mycobacteria with special reference to M. tuberculosis. Curr. Sci. (Bangalore) 86:93-102.
29. World Health Organization. 2010. Global tuberculosis control fact sheet. World Health Organization, Geneva, Switzerland.
30. Zahrt T, Deretic V. 2001. Mycobacterium tuberculosis signal transduction system required for persistent infections. Proc. Natl. Acad. Sci. U. S. A. 98:12706-12711.
31. Zahrt TA, Deretic V. 2000. An essential two-component signal transduction system in Mycobacterium tuberculosis. J. Bacteriol. 182:3832-3838.
32. Zahrt TC, Wozniak C, Jones D, Trevett A. 2003. Functional analysis of the Mycobacterium tuberculosis MprAB two-component signal transduction system. Infect. Immun. 71:6962-6970.