Using an advanced microfermentor system for strain screening and fermentation optimization

Methods in Molecular Biology

Volumn 834, Issue , 2012, Pages 217-231

  Xie, Dongming ^a  

^a DUPONT COMPANY   (United States)

Author keywords

Fermentation; Industrial biotechnology; Microbioreactor; Microfermentor; Optimization; Strain screening

Indexed keywords

ARTICLE; BIOREACTOR; BIOTECHNOLOGY; CRYOPRESERVATION; FERMENTATION; INSTRUMENTATION; METHODOLOGY; MICROBIOLOGY;

BIOREACTORS; BIOTECHNOLOGY; CRYOPRESERVATION; FERMENTATION; INDUSTRIAL MICROBIOLOGY;

EID: 84855883689     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-483-4_14     Document Type: Article

References (22)

1. Michael J. Waites, Neil L. Morgan, John S. Rockey, and Gary Higton (2001) Industrial microbiology: an introduction. Wiley- Blackwell.
2. Schäpper D., Alam M.N.H.Z., Szita N., and Lantz A.E., and Gernaey K.V. (2009) Application of microbioreactors in fermentation process development: a review. Anal Bioanal Chem 395 , 679-695.
3. Weuster-Botz D., Hekmat D., Puskeiler R., and Franco-Lara E. (2007) Enabling Technologies: Fermentation and Downstream Processing. Adv Biochem Eng Biotechnol 105 , 205-247.
4. Kumar S., Wittmann C., and Heinzle E. (2004) Minibioreactors. Biotechnology Letters 26, 1-10. (Pubitemid 38161949)
5. Jonathan I Betts and Frank Baganz (2006) Miniature bioreactors: current practices and future opportunities. Microbial Cell Factories 5, 21.
6. Fernandes P. and Cabral J.M.S. (2006) Microlitre/millilitre shaken bioreactors in fermentative and biotransformation processes-A review. Biocatal Biotransformation 24 , 237-252.
7. Büchs J. (2001) Introduction to advantages and problems of shaken cultures. Biochem Eng J 7 , 91-98. (Pubitemid 32162694)
8. Anderlei T., Büchs J. (2001) Device for sterile online measurement of the oxygen transfer rate in shaking fl asks. Biochem Eng J 7 , 157-162. (Pubitemid 32162704)
9. Wittmann C., Kim H.M., John G., Heinzle E. (2003) Characterisation and application of an optical sensor for quantifi cation of dissolved oxygen in shake-fl asks. Biotechnol Lett 25 , 377-380.
10. Danielson P.B., Büchs J., Stockmann C., Fogleman J.C. (2004) Maximizing cell densities in miniprep-scale cultures with H15 medium and improved oxygen transfer. Biochem Eng J 17 , 175-180. (Pubitemid 38201453)
11. Stockmann C., Losen M., Dahlems U., Knocke C., Gellissen G., Büchs J. (2003) Effect of oxygen supply on passaging, stabilizing and screening of recombinant Hansenula polymorpha production strains in test tube cultures. FEMS Yeast Res 4 , 195-205.
12. Houston J.G., Banks M. (1997) The chemicalbiologicaLinterface: developments in automated and miniaturised screening technology. Curr Opin Biotechnol 8 , 734-740. (Pubitemid 27517251)
13. Duetz W.A., Ruedi L., Hermann R., O'Connor K., Büchs J., Witholt B. (2000) Methods for intense aeration, growth, storage and replication of bacterial strains in microtiter plates. Appl Environ Microbiol 66 , 2641-2646. (Pubitemid 30353977)
14. Micro-24 MicroReactor System. See http://www.pall.com/biopharm-52961.asp.
15. Doig S.D., Diep A., Baganz F. (2005) Characterisation of a novel miniaturized bubble column bioreactor for high throughput cell cultivation. Biochem Eng J 23 , 97-105. (Pubitemid 40193462)
16. Betts J.I., Doig S.D., Baganz F. (2006) The characterization and application of a miniature 10 ml stirred-tank bioreactor, showing scaledown equivalence with a conventional 7L reactor. Biotechnol Prog 22 , 681-688. (Pubitemid 43877435)
17. Gilla N.K., Appletonb M., Baganza F., and Lye G.J. (2008) Design and characterisation of a miniature stirred bioreactor system for parallel microbial fermentations. Biochem Eng J 39 , 164-176. (Pubitemid 351625648)
18. Xie D. , Shao Z., Achkar J., Zha W., Frost J.W., and Zhao H. (2006) Microbial synthesis of Triacetic Acid Lactone. Biotechnol Bioeng 93 , 727-736.
19. Funke M., Buchenauer A., Schnakenberg U., Mokwa W., Diederichs S., Mertens A., Muller C., Kensy F., Buchs J. (2010) Microfl uidic BioLector-Microfl uidic Bioprocess ControLin Microtiter Plates. Biotechnol Bioeng 107,497-505.
20. Amanullah A., Otero J.M., Mikola M., Hsu A., Zhang J., Aunins J., Schreyer HB., Hope J.A., Russo A.P. (2010) Novel micro-bioreactor high throughput technology for cell culture process development: Reproducibility and scalability assessment of fed-batch CHO cultures. Biotechnol Bioeng 106 , 57-67.
21. Cellstation high throughput bioreactors. See http://www.fl uorometrix.com .
22. DAS GIP parallel system for microbial fermentation in process development. See http://www.dasgip.com