Stimulation of the extracellular Ca 2+-sensing receptor by denatonium

Biochemical and Biophysical Research Communications

Volumn 416, Issue 3-4, 2011, Pages 433-436

  Rogachevskaja, Olga A ^a   Churbanov, Gleb D ^a   Bystrova, Marina F ^a   Romanov, Roman A ^a   Kolesnikov, Stanislav S ^a  

^a INSTITUTE OF CELL BIOPHYSICS   (Russian Federation)

Author keywords

Ca 2+ imaging; Denatonium; Extracellular Ca 2+ sensing receptor; Heterologous expression

Indexed keywords

CALCIUM SENSING RECEPTOR; DENATONIUM BENZOATE;

ARTICLE; BITTER TASTE; CELL STRAIN HEK293; DOSE RESPONSE; EMBRYO; EXTRACELLULAR CALCIUM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; STIMULATION; STIMULUS RESPONSE; SWEAT;

ASPARTAME; CYCLOHEXIMIDE; DIPEPTIDES; GUANIDINES; HEK293 CELLS; HUMANS; QUATERNARY AMMONIUM COMPOUNDS; RECEPTORS, CALCIUM-SENSING; RECEPTORS, G-PROTEIN-COUPLED; SUCROSE; SWEETENING AGENTS;

EID: 84855881673     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.11.095     Document Type: Article

References (17)

1. Bystrova M.F., Romanov R.A., Rogachevskaja O.A., Churbanov G.D., Kolesnikov S.S. Functional expression of the extracellular calcium-sensing receptor in mouse taste cell. J. Cell Sci. 2010, 123:972-982.
2. 2+-sensing receptors. Biochem. Soc. Trans. 2007, 35:1195-1198.
3. Wellendorph P., Brauner-Osborne H. Molecular basis for amino acid sensing by family C G-protein-coupled receptors. Br. J. Pharm. 2009, 156:869-884.
4. Tordoff M.G. Some basic psychophysics of calcium salt solutions. Chem. Senses 1996, 21:417-424.
5. Shigemura N., Shirosaki S., Ohkuri T., Sanematsu K., Islam A.A., Ogiwara Y., Kawai M., Yoshida R., Ninomiya Y. Variation in umami perception and in candidate genes for the umami receptor in mice and humans. Am. J. Clin. Nutr. 2009, 90:764S-769S.
6. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985, 260:3440-3450.
7. 2+-sensing receptor. Eur. J. Pharm. 2002, 447:271-278.
8. Nemeth E.F. Receptor antagonists. The search for calcium receptor antagonists (calcilytics). J. Mol. Endocrinol. 2002, 29:15-21.
9. 2+-sensing receptor. Proc. Natl. Acad. Sci. USA 2000, 97:4814-4819.
10. 2+-sensing receptors: a domain-based survey of requirements for binding and signaling. Br. J. Pharm. 2010, 159:1039-1050.
11. Chaudhari N., Roper S.D. The cell biology of taste. J. Cell Biol. 2010, 190:285-296.
12. Gabriel A.S., Uneyama H., Maekawa T., Torii K. The calcium-sensing receptor in taste tissue. Biochem. Biophys. Res. Commun. 2009, 378:414-418.
13. Hofer A.M., Brown E.M. Extracellular calcium sensing and signaling. Nat. Rev. Mol. Cell. Biol. 2003, 4:530-538.
14. Zubare-Samuelov M., Peri I., Tal M., Tarshish M., Spielman A.I., Naim M. Some sweet and bitter tastants stimulate inhibitory pathway of adenylyl cyclase via melatonin and a2-adrenergic receptors in Xenopus laevis melanophores. Am. J. Physiol. Cell Physiol. 2003, 285:1255-1262.
15. Joshi M.S., Ferguson Jr T.B., Johnson F.K., Johnson R.A., Parthasarathy S., Lancaster J.R. Receptor-mediated activation of nitric oxide synthesis by arginine in endothelial cells. Proc. Natl. Acad. Sci. USA 2007, 104:9982-9987.
16. Nelson G., Chandrashekar J., Hoon M.A., Feng L., Zhao G., Ryba N.J.P., Zuker C.S. An amino-acid taste receptor. Nature 2002, 416:199-202.
17. Ohsu T., Amino Y., Nagasaki H., Yamanaka T., Takeshita S., Hatanaka T., Maruyama Y., Miyamura N., Eto Y. Involvement of the calcium-sensing receptor in human taste perception. J. Biol. Chem. 2010, 285:1016-1022.