Transgenic mice with SCA10 pentanucleotide repeats show motor phenotype and susceptibility to seizure: A toxic RNA gain-of-function model

Journal of Neuroscience Research

Volumn 90, Issue 3, 2012, Pages 706-714

  White, Misti ^a   Xia, Guangbin ^a,b   Gao, Rui ^a   Wakamiya, Maki ^a   Sarkar, Partha S ^a   McFarland, Karen ^b   Ashizawa, Tetsuo ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

Neurodegenerative disorder; Nucleotide repeat; RNA gain of function

Indexed keywords

CASPASE 3; PROTEIN KINASE C DELTA; RNA;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GAIT DISORDER; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INTRON; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE REPEAT; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN AGGREGATION; SEIZURE; SPINOCEREBELLAR ATAXIA TYPE 10; SPINOCEREBELLAR DEGENERATION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; CARRIER PROTEINS; GAIT; MICE; MICE, TRANSGENIC; MICROSATELLITE REPEATS; MOTOR ACTIVITY; PHENOTYPE; RNA; SEIZURES;

EID: 84855877969     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22786     Document Type: Article

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