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Volumn 64, Issue 2, 2012, Pages 126-135

Neuroprotective and neuroregenerative properties of metallothioneins

Author keywords

Alzheimer disease; brain; metallothionein 1; metallothionein 2; metallothionein 3; neuroprotection; neuroregeneration; oxidative stress; zinc binding

Indexed keywords

METALLOTHIONEIN; METALLOTHIONEIN I; METALLOTHIONEIN II; ZINC;

EID: 84855863743     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.585     Document Type: Review
Times cited : (41)

References (78)
  • 1
    • 0025222043 scopus 로고
    • Human metallothionein genes: Structure of the functional locus at 16q13
    • West, A. K., Stallings, R., Hildebrand, C. E., Chiu, R., Karin, M., et al. (1990) Human metallothionein genes: structure of the functional locus at 16q13. Genomics 8, 513-518.
    • (1990) Genomics , vol.8 , pp. 513-518
    • West, A.K.1    Stallings, R.2    Hildebrand, C.E.3    Chiu, R.4    Karin, M.5
  • 2
    • 24344457080 scopus 로고    scopus 로고
    • Advances in metallothionein structure and functions
    • DOI 10.1016/j.jtemb.2005.03.003, PII S0946672X05000313
    • Vasak, M., (2005) Advances in metallothionein structure and functions. J. Trace Elem. Med. Biol. 19, 13-17. (Pubitemid 41253912)
    • (2005) Journal of Trace Elements in Medicine and Biology , vol.19 , Issue.SPEC. ISS. , pp. 13-17
    • Vasak, M.1
  • 4
    • 43549085481 scopus 로고    scopus 로고
    • Metallothionein-3 is expressed in the brain and various peripheral organs of the rat
    • Hozumi, I., Suzuki, J. S., Kanazawa, H., Hara, A., Saio, M., et al. (2008) Metallothionein-3 is expressed in the brain and various peripheral organs of the rat. Neurosci. Lett. 438, 54-58.
    • (2008) Neurosci. Lett. , vol.438 , pp. 54-58
    • Hozumi, I.1    Suzuki, J.S.2    Kanazawa, H.3    Hara, A.4    Saio, M.5
  • 5
    • 11244270832 scopus 로고    scopus 로고
    • Expression of neuronal growth inhibitory factor (metallothionein-III) in the salivary gland
    • Irie, Y., Mori, F., Keung, W. M., Mizushima, Y., and, Wakabayashi, K., (2004) Expression of neuronal growth inhibitory factor (metallothionein-III) in the salivary gland. Physiol. Res. 53, 719-723. (Pubitemid 40065702)
    • (2004) Physiological Research , vol.53 , Issue.6 , pp. 719-723
    • Irie, Y.1    Mori, F.2    Keung, W.M.3    Mizushima, Y.4    Wakabayashi, K.5
  • 6
    • 77954355688 scopus 로고    scopus 로고
    • Neuronal growth-inhibitory factor (metallothionein-3): Structure-function relationships
    • Ding, Z. C., Ni, F. Y., and, Huang, Z. X., (2010) Neuronal growth-inhibitory factor (metallothionein-3): structure-function relationships. FEBS J. 277, 2912-2920.
    • (2010) FEBS J. , vol.277 , pp. 2912-2920
    • Ding, Z.C.1    Ni, F.Y.2    Huang, Z.X.3
  • 7
    • 77954377635 scopus 로고    scopus 로고
    • Neuronal growth-inhibitory factor (metallothionein-3): Reactivity and structure of metal-thiolate clusters
    • Faller, P., (2010) Neuronal growth-inhibitory factor (metallothionein-3): reactivity and structure of metal-thiolate clusters. FEBS J. 277, 2921-2930.
    • (2010) FEBS J. , vol.277 , pp. 2921-2930
    • Faller, P.1
  • 8
    • 59449095419 scopus 로고    scopus 로고
    • Molecular aspects of human cellular zinc homeostasis: Redox control of zinc potentials and zinc signals
    • Maret, W., (2009) Molecular aspects of human cellular zinc homeostasis: redox control of zinc potentials and zinc signals. Biometals 22, 149-157.
    • (2009) Biometals , vol.22 , pp. 149-157
    • Maret, W.1
  • 9
    • 77958147359 scopus 로고    scopus 로고
    • (2010) Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes
    • Lee, S. J., and, Koh, J. Y., (2010) Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes. Molecular brain 3, 30.
    • Molecular Brain , vol.3 , pp. 30
    • Lee, S.J.1    Koh, J.Y.2
  • 11
    • 18144406139 scopus 로고    scopus 로고
    • Metal components analysis of metallothionein-III in the brain sections of metallothionein-I and metallothionein-II null mice exposed to mercury vapor with HPLC/ICP-MS
    • DOI 10.1007/s00216-005-3157-9
    • Kameo, S., Nakai, K., Kurokawa, N., Kanehisa, T., Naganuma, A., et al. (2005) Metal components analysis of metallothionein-III in the brain sections of metallothionein-I and metallothionein-II null mice exposed to mercury vapor with HPLC/ICP-MS. Anal. Bioanal. Chem. 381, 1514-1519. (Pubitemid 40609384)
    • (2005) Analytical and Bioanalytical Chemistry , vol.381 , Issue.8 , pp. 1514-1519
    • Kameo, S.1    Nakai, K.2    Kurokawa, N.3    Kanehisa, T.4    Naganuma, A.5    Satoh, H.6
  • 13
    • 0346457011 scopus 로고    scopus 로고
    • Neuron-glia communication: Metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury
    • Chung, R. S., Adlard, P. A., Dittmann, J., Vickers, J. C., Chuah, M. I., et al. (2004) Neuron-glia communication: metallothionein expression is specifically up-regulated by astrocytes in response to neuronal injury. J. Neurochem. 88, 454-461. (Pubitemid 38084561)
    • (2004) Journal of Neurochemistry , vol.88 , Issue.2 , pp. 454-461
    • Chung, R.S.1    Adlard, P.A.2    Dittmann, J.3    Vickers, J.C.4    Chuah, M.I.5    West, A.K.6
  • 14
    • 33646268801 scopus 로고    scopus 로고
    • Metallothioneins are multipurpose neuroprotectants during brain pathology
    • Penkowa, M., (2006) Metallothioneins are multipurpose neuroprotectants during brain pathology. FEBS J. 273, 1857-1870.
    • (2006) FEBS J. , vol.273 , pp. 1857-1870
    • Penkowa, M.1
  • 15
    • 77955239777 scopus 로고    scopus 로고
    • Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin
    • Martinho, A., Goncalves, I., Cardoso, I., Almeida, M. R., Quintela, T., et al. (2010) Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin. FEBS J. 277, 3427-3436.
    • (2010) FEBS J. , vol.277 , pp. 3427-3436
    • Martinho, A.1    Goncalves, I.2    Cardoso, I.3    Almeida, M.R.4    Quintela, T.5
  • 16
    • 0027048685 scopus 로고
    • Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease
    • Tsuji, S., Kobayashi, H., Uchida, Y., Ihara, Y., and, Miyatake, T., (1992) Molecular cloning of human growth inhibitory factor cDNA and its down-regulation in Alzheimer's disease. EMBO J. 11, 4843-4850. (Pubitemid 23023427)
    • (1992) EMBO Journal , vol.11 , Issue.13 , pp. 4843-4850
    • Tsuji, S.1    Kobayashi, H.2    Uchida, Y.3    Ihara, Y.4    Miyatake, T.5
  • 17
    • 0029121636 scopus 로고
    • Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes
    • Amoureux, M. C., Wurch, T., and, Pauwels, P. J., (1995) Modulation of metallothionein-III mRNA content and growth rate of rat C6-glial cells by transfection with human 5-HT1D receptor genes. Biochem. Biophys. Res. Commun. 214, 639-645.
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 639-645
    • Amoureux, M.C.1    Wurch, T.2    Pauwels, P.J.3
  • 18
    • 0030574080 scopus 로고    scopus 로고
    • Subcellular localization of growth inhibitory factor in rat brain: Light and electron microscopic immunohistochemical studies
    • DOI 10.1016/0006-8993(96)00586-0
    • Yamada, M., Hayashi, S., Hozumi, I., Inuzuka, T., Tsuji, S., et al. (1996) Subcellular localization of growth inhibitory factor in rat brain: light and electron microscopic immunohistochemical studies. Brain Res. 735, 257-264. (Pubitemid 26345937)
    • (1996) Brain Research , vol.735 , Issue.2 , pp. 257-264
    • Yamada, M.1    Hayashi, S.2    Hozumi, I.3    Inuzuka, T.4    Tsuji, S.5    Takahashi, H.6
  • 19
    • 0033588813 scopus 로고    scopus 로고
    • Distribution of metallothionein I + II and vesicular zinc in the developing central nervous system: Correlative study in the rat
    • DOI 10.1002/(SICI)1096-9861(19990920)412:2<303::AID-CNE9>3.0.CO;2-G
    • Penkowa, M., Nielsen, H., Hidalgo, J., Bernth, N., and, Moos, T., (1999) Distribution of metallothionein I + II and vesicular zinc in the developing central nervous system: correlative study in the rat. J. Comp. Neurol. 412, 303-318. (Pubitemid 29395367)
    • (1999) Journal of Comparative Neurology , vol.412 , Issue.2 , pp. 303-318
    • Penkowa, M.1    Nielsen, H.2    Hidalgo, J.3    Bernth, N.4    Moos, T.5
  • 20
    • 0032747632 scopus 로고    scopus 로고
    • Metallothionein (MT)-III: Generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains
    • Carrasco, J., Giralt, M., Molinero, A., Penkowa, M., Moos, T., et al. (1999) Metallothionein (MT)-III: generation of polyclonal antibodies, comparison with MT-I+II in the freeze lesioned rat brain and in a bioassay with astrocytes, and analysis of Alzheimer's disease brains. J. Neurotrauma 16, 1115-1129.
    • (1999) J. Neurotrauma , vol.16 , pp. 1115-1129
    • Carrasco, J.1    Giralt, M.2    Molinero, A.3    Penkowa, M.4    Moos, T.5
  • 22
    • 0033119327 scopus 로고    scopus 로고
    • CNS wound healing is severely depressed in metallothionein I- and II- deficient mice
    • Penkowa, M., Carrasco, J., Giralt, M., Moos, T., and, Hidalgo, J., (1999) CNS wound healing is severely depressed in metallothionein I- and II-deficient mice. J. Neurosci. 19, 2535-2545. (Pubitemid 29162402)
    • (1999) Journal of Neuroscience , vol.19 , Issue.7 , pp. 2535-2545
    • Penkowa, M.1    Carrasco, J.2    Giralt, M.3    Moos, T.4    Hidalgo, J.5
  • 23
    • 0033931868 scopus 로고    scopus 로고
    • Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice
    • DOI 10.1046/j.1460-9568.2000.00128.x
    • Carrasco, J., Penkowa, M., Hadberg, H., Molinero, A., and, Hidalgo, J., (2000) Enhanced seizures and hippocampal neurodegeneration following kainic acid-induced seizures in metallothionein-I + II-deficient mice. Eur. J. Neurosci. 12, 2311-2322. (Pubitemid 30497029)
    • (2000) European Journal of Neuroscience , vol.12 , Issue.7 , pp. 2311-2322
    • Carrasco, J.1    Penkowa, M.2    Hadberg, H.3    Molinero, A.4    Hidalgo, J.5
  • 25
    • 34547683905 scopus 로고    scopus 로고
    • Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia
    • DOI 10.1016/j.neuroscience.2007.04.063, PII S0306452207005453
    • Wakida, K., Shimazawa, M., Hozumi, I., Satoh, M., Nagase, H., et al. (2007) Neuroprotective effect of erythropoietin, and role of metallothionein-1 and -2, in permanent focal cerebral ischemia. Neuroscience 148, 105-114. (Pubitemid 47211609)
    • (2007) Neuroscience , vol.148 , Issue.1 , pp. 105-114
    • Wakida, K.1    Shimazawa, M.2    Hozumi, I.3    Satoh, M.4    Nagase, H.5    Inuzuka, T.6    Hara, H.7
  • 26
    • 0038407699 scopus 로고    scopus 로고
    • Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte - Targeted interleukin-6 expression
    • DOI 10.1002/glia.10208
    • Penkowa, M., Camats, J., Giralt, M., Molinero, A., Hernandez, J., et al. (2003) Metallothionein-I overexpression alters brain inflammation and stimulates brain repair in transgenic mice with astrocyte-targeted interleukin-6 expression. Glia 42, 287-306. (Pubitemid 36538341)
    • (2003) GLIA , vol.42 , Issue.3 , pp. 287-306
    • Penkowa, M.1    Camats, J.2    Giralt, M.3    Molinero, A.4    Hernandez, J.5    Carrasco, J.6    Campbell, I.L.7    Hidalgo, J.8
  • 28
    • 0031016825 scopus 로고    scopus 로고
    • Disruption of the metallothionein-III gene in mice: Analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures
    • Erickson, J. C., Hollopeter, G., Thomas, S. A., Froelick, G. J., and, Palmiter, R. D., (1997) Disruption of the metallothionein-III gene in mice: analysis of brain zinc, behavior, and neuron vulnerability to metals, aging, and seizures. J. Neurosci. 17, 1271-1281. (Pubitemid 27073729)
    • (1997) Journal of Neuroscience , vol.17 , Issue.4 , pp. 1271-1281
    • Erickson, J.C.1    Hollopeter, G.2    Thomas, S.A.3    Froelick, G.J.4    Palmiter, R.D.5
  • 29
    • 69449098301 scopus 로고    scopus 로고
    • Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia
    • Koumura, A., Hamanaka, J., Shimazawa, M., Honda, A., Tsuruma, K., et al. (2009) Metallothionein-III knockout mice aggravates the neuronal damage after transient focal cerebral ischemia. Brain Res. 1292, 148-154.
    • (2009) Brain Res. , vol.1292 , pp. 148-154
    • Koumura, A.1    Hamanaka, J.2    Shimazawa, M.3    Honda, A.4    Tsuruma, K.5
  • 31
    • 0036148593 scopus 로고    scopus 로고
    • Metallothionein-1+2 protect the CNS after a focal brain injury
    • DOI 10.1006/exnr.2001.7772
    • Giralt, M., Penkowa, M., Lago, N., Molinero, A., and, Hidalgo, J., (2002) Metallothionein-1+2 protect the CNS after a focal brain injury. Exp. Neurol. 173, 114-128. (Pubitemid 34081731)
    • (2002) Experimental Neurology , vol.173 , Issue.1 , pp. 114-128
    • Giralt, M.1    Penkowa, M.2    Lago, N.3    Molinero, A.4    Hidalgo, J.5
  • 32
    • 0037996720 scopus 로고    scopus 로고
    • Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury
    • Chung, R. S., Vickers, J. C., Chuah, M. I., and, West, A. K., (2003) Metallothionein-IIA promotes initial neurite elongation and postinjury reactive neurite growth and facilitates healing after focal cortical brain injury. J. Neurosci. 23, 3336-3342. (Pubitemid 36531975)
    • (2003) Journal of Neuroscience , vol.23 , Issue.8 , pp. 3336-3342
    • Chung, R.S.1    Vickers, J.C.2    Chuah, M.I.3    West, A.K.4
  • 33
    • 33645843958 scopus 로고    scopus 로고
    • Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury
    • Penkowa, M., Tio, L., Giralt, M., Quintana, A., Molinero, A., et al. (2006) Specificity and divergence in the neurobiologic effects of different metallothioneins after brain injury. J. Neurosci. Res. 83, 974-984.
    • (2006) J. Neurosci. Res. , vol.83 , pp. 974-984
    • Penkowa, M.1    Tio, L.2    Giralt, M.3    Quintana, A.4    Molinero, A.5
  • 34
    • 77952357223 scopus 로고    scopus 로고
    • The comparison of mouse full metallothionein-1 versus alpha and beta domains and metallothionein-1-to-3 mutation following traumatic brain injury reveals different biological motifs
    • Manso, Y., Serra, M., Comes, G., Giralt, M., Carrasco, J., et al. (2010) The comparison of mouse full metallothionein-1 versus alpha and beta domains and metallothionein-1-to-3 mutation following traumatic brain injury reveals different biological motifs. J. Neurosci. Res. 88, 1708-1718.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 1708-1718
    • Manso, Y.1    Serra, M.2    Comes, G.3    Giralt, M.4    Carrasco, J.5
  • 35
    • 78751691004 scopus 로고    scopus 로고
    • Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity
    • Miyazaki, I., Asanuma, M., Kikkawa, Y., Takeshima, M., Murakami, S., et al. (2011) Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Glia 59, 435-451.
    • (2011) Glia , vol.59 , pp. 435-451
    • Miyazaki, I.1    Asanuma, M.2    Kikkawa, Y.3    Takeshima, M.4    Murakami, S.5
  • 36
    • 79951576906 scopus 로고    scopus 로고
    • Basal metallothionein-I/II protects against NMDA-mediated oxidative injury in cortical neuron/astrocyte cultures
    • Yu, X., Guo, J., Fang, H., and, Peng, S., (2011) Basal metallothionein-I/II protects against NMDA-mediated oxidative injury in cortical neuron/astrocyte cultures. Toxicology 282, 16-22.
    • (2011) Toxicology , vol.282 , pp. 16-22
    • Yu, X.1    Guo, J.2    Fang, H.3    Peng, S.4
  • 37
    • 37249056581 scopus 로고    scopus 로고
    • Metallothionein and a peptide modeled after metallothionein, EmtinB, induce neuronal differentiation and survival through binding to receptors of the low-density lipoprotein receptor family
    • DOI 10.1111/j.1471-4159.2007.05036.x
    • Ambjorn, M., Asmussen, J. W., Lindstam, M., Gotfryd, K., Jacobsen, C., et al. (2008) Metallothionein and a peptide modeled after metallothionein, EmtinB, induce neuronal differentiation and survival through binding to receptors of the low-density lipoprotein receptor family. J.Neurochem. 104, 21-37. (Pubitemid 350265072)
    • (2008) Journal of Neurochemistry , vol.104 , Issue.1 , pp. 21-37
    • Ambjorn, M.1    Asmussen, J.W.2    Lindstam, M.3    Gotfryd, K.4    Jacobsen, C.5    Kiselyov, V.V.6    Moestrup, S.K.7    Penkowa, M.8    Bock, E.9    Berezin, V.10
  • 38
    • 67349089563 scopus 로고    scopus 로고
    • Peptides modeled after the alpha-domain of metallothionein induce neurite outgrowth and promote survival of cerebellar granule neurons
    • Asmussen, J. W., Ambjorn, M., Bock, E., and, Berezin, V., (2009) Peptides modeled after the alpha-domain of metallothionein induce neurite outgrowth and promote survival of cerebellar granule neurons. Eur. J. Cell Biol. 88, 433-443.
    • (2009) Eur. J. Cell Biol. , vol.88 , pp. 433-443
    • Asmussen, J.W.1    Ambjorn, M.2    Bock, E.3    Berezin, V.4
  • 39
    • 32244434439 scopus 로고    scopus 로고
    • Growth inhibitory factor (GIF) can protect from brain damage due to stab wounds in rat brain
    • DOI 10.1016/j.neulet.2005.10.093, PII S0304394005012607
    • Hozumi, I., Uchida, Y., Watabe, K., Sakamoto, T., and, Inuzuka, T., (2006) Growth inhibitory factor (GIF) can protect from brain damage due to stab wounds in rat brain. Neurosci. Lett. 395, 220-223. (Pubitemid 43213148)
    • (2006) Neuroscience Letters , vol.395 , Issue.3 , pp. 220-223
    • Hozumi, I.1    Uchida, Y.2    Watabe, K.3    Sakamoto, T.4    Inuzuka, T.5
  • 40
    • 79952322848 scopus 로고    scopus 로고
    • Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8)
    • Ma, F., Wang, H., Chen, B., Wang, F., and, Xu, H., (2011) Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8). Arq. Neuropsiquiatr. 69, 105-111.
    • (2011) Arq. Neuropsiquiatr. , vol.69 , pp. 105-111
    • Ma, F.1    Wang, H.2    Chen, B.3    Wang, F.4    Xu, H.5
  • 41
    • 0036445576 scopus 로고    scopus 로고
    • Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting
    • DOI 10.1006/exnr.2002.8017
    • Chung, R. S., Vickers, J. C., Chuah, M. I., Eckhardt, B. L., and, West, A. K., (2002) Metallothionein-III inhibits initial neurite formation in developing neurons as well as postinjury, regenerative neurite sprouting. Exp. Neurol. 178, 1-12. (Pubitemid 35425604)
    • (2002) Experimental Neurology , vol.178 , Issue.1 , pp. 1-12
    • Chung, R.S.1    Vickers, J.C.2    Chuah, M.I.3    Eckhardt, B.L.4    West, A.K.5
  • 42
    • 0034047740 scopus 로고    scopus 로고
    • Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons
    • DOI 10.1046/j.1471-4159.2000.0750266.x
    • Montoliu, C., Monfort, P., Carrasco, J., Palacios, O., Capdevila, M., etal. (2000) Metallothionein-III prevents glutamate and nitric oxide neurotoxicity in primary cultures of cerebellar neurons. J. Neurochem. 75, 266-273. (Pubitemid 30418192)
    • (2000) Journal of Neurochemistry , vol.75 , Issue.1 , pp. 266-273
    • Montoliu, C.1    Monfort, P.2    Carrasco, J.3    Palacios, O.4    Capdevila, M.5    Hidalgo, J.6    Felipo, V.7
  • 44
    • 0037200013 scopus 로고    scopus 로고
    • Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging
    • DOI 10.1074/jbc.M111263200
    • Uchida, Y., Gomi, F., Masumizu, T., and, Miura, Y., (2002) Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging. J. Biol. Chem. 277, 32353-32359. (Pubitemid 34969053)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.35 , pp. 32353-32359
    • Uchida, Y.1    Gomi, F.2    Masumizu, T.3    Miura, Y.4
  • 45
    • 1642382190 scopus 로고    scopus 로고
    • Attenuation of zinc-induced neuronal death by the interaction of growth inhibitory factor with Rab3A in rat hippocampal neurons
    • DOI 10.1016/j.neulet.2003.12.087, PII S0304394004000114
    • Liu, Y., Ren, H., Wu, C., Bai, S., Zhang, X., et al. (2004) Attenuation of zinc-induced neuronal death by the interaction of growth inhibitory factor with Rab3A in rat hippocampal neurons. Neurosci. Lett. 358, 149-152. (Pubitemid 38368191)
    • (2004) Neuroscience Letters , vol.358 , Issue.3 , pp. 149-152
    • Liu, Y.1    Ren, H.2    Wu, C.3    Bai, S.4    Zhang, X.5    Ru, B.6
  • 46
    • 0037449446 scopus 로고    scopus 로고
    • Anti-amyloid β activity of metallothionein-III is different from its neuronal growth inhibitory activity: Structure-activity studies
    • DOI 10.1016/S0006-8993(02)03891-X, PII S000689930203891X
    • Irie, Y., and, Keung, W. M., (2003) Anti-amyloid beta activity of metallothionein-III is different from its neuronal growth inhibitory activity: structure-activity studies. Brain Res. 960, 228-234. (Pubitemid 36044580)
    • (2003) Brain Research , vol.960 , Issue.1-2 , pp. 228-234
    • Irie, Y.1    Keung, W.M.2
  • 47
    • 0028263925 scopus 로고
    • Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF)
    • DOI 10.1016/0006-8993(94)91076-6
    • Erickson, J. C., Sewell, A. K., Jensen, L. T., Winge, D. R., and, Palmiter, R. D., (1994) Enhanced neurotrophic activity in Alzheimer's disease cortex is not associated with down-regulation of metallothionein-III (GIF). Brain Res. 649, 297-304. (Pubitemid 24197224)
    • (1994) Brain Research , vol.649 , Issue.1-2 , pp. 297-304
    • Erickson, J.C.1    Sewell, A.K.2    Jensen, L.T.3    Winge, D.R.4    Palmiter, R.D.5
  • 49
    • 0029257277 scopus 로고
    • Disruption of the blood-brain interface in neonatal rat neocortex induces a transient expression of metallothionein in reactive astrocytes
    • Penkowa, M., and, Moos, T., (1995) Disruption of the blood-brain interface in neonatal rat neocortex induces a transient expression of metallothionein in reactive astrocytes. Glia 13, 217-227.
    • (1995) Glia , vol.13 , pp. 217-227
    • Penkowa, M.1    Moos, T.2
  • 50
    • 33750600258 scopus 로고    scopus 로고
    • Novel roles for metallothionein-I + II (MT-I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: Insights from global gene expression profiling in wild-type and MT-I + II knockout mice
    • DOI 10.1002/jnr.21043
    • Penkowa, M., Caceres, M., Borup, R., Nielsen, F. C., Poulsen, C. B., et al. (2006) Novel roles for metallothionein-I + II (MT-I + II) in defense responses, neurogenesis, and tissue restoration after traumatic brain injury: insights from global gene expression profiling in wild-type and MT-I + II knockout mice. J. Neurosci. Res. 84, 1452-1474. (Pubitemid 44683139)
    • (2006) Journal of Neuroscience Research , vol.84 , Issue.7 , pp. 1452-1474
    • Penkowa, M.1    Caceres, M.2    Borup, R.3    Nielsen, F.C.4    Poulsen, C.B.5    Quintana, A.6    Molinero, A.7    Carrasco, J.8    Florit, S.9    Giralt, M.10    Hidalgo, J.11
  • 51
    • 47249146602 scopus 로고    scopus 로고
    • Redefining the role of metallothionein within the injured brain: Extracellular metallothioneins play an important role in the astrocyte-neuron response to injury
    • Chung, R. S., Penkowa, M., Dittmann, J., King, C. E., Bartlett, C., et al. (2008) Redefining the role of metallothionein within the injured brain: extracellular metallothioneins play an important role in the astrocyte-neuron response to injury. J. Biol. Chem. 283, 15349-15358.
    • (2008) J. Biol. Chem. , vol.283 , pp. 15349-15358
    • Chung, R.S.1    Penkowa, M.2    Dittmann, J.3    King, C.E.4    Bartlett, C.5
  • 52
    • 70449348627 scopus 로고    scopus 로고
    • Intraneuronal signaling pathways of metallothionein
    • Asmussen, J. W., Von Sperling, M. L., and, Penkowa, M., (2009) Intraneuronal signaling pathways of metallothionein. J. Neurosci. Res. 87, 2926-2936.
    • (2009) J. Neurosci. Res. , vol.87 , pp. 2926-2936
    • Asmussen, J.W.1    Von Sperling, M.L.2    Penkowa, M.3
  • 53
    • 72749118269 scopus 로고    scopus 로고
    • Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways
    • Leung, Y. K., Pankhurst, M., Dunlop, S. A., Ray, S., Dittmann, J., et al. (2010) Metallothionein induces a regenerative reactive astrocyte phenotype via JAK/STAT and RhoA signalling pathways. Exp. Neurol. 221, 98-106.
    • (2010) Exp. Neurol. , vol.221 , pp. 98-106
    • Leung, Y.K.1    Pankhurst, M.2    Dunlop, S.A.3    Ray, S.4    Dittmann, J.5
  • 54
    • 77950112364 scopus 로고    scopus 로고
    • A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity
    • Sonn, K., Pankratova, S., Korshunova, I., Zharkovsky, A., Bock, E., et al. (2010) A metallothionein mimetic peptide protects neurons against kainic acid-induced excitotoxicity. J. Neurosci. Res. 88, 1074-1082.
    • (2010) J. Neurosci. Res. , vol.88 , pp. 1074-1082
    • Sonn, K.1    Pankratova, S.2    Korshunova, I.3    Zharkovsky, A.4    Bock, E.5
  • 56
    • 69149098253 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription-3, inflammation, and cancer: How intimate is the relationship?
    • Aggarwal, B. B., Kunnumakkara, A. B., Harikumar, K. B., Gupta, S. R., Tharakan, S. T., et al. (2009) Signal transducer and activator of transcription-3, inflammation, and cancer: how intimate is the relationship? Ann. NY Acad. Sci. 1171, 59-76.
    • (2009) Ann. NY Acad. Sci. , vol.1171 , pp. 59-76
    • Aggarwal, B.B.1    Kunnumakkara, A.B.2    Harikumar, K.B.3    Gupta, S.R.4    Tharakan, S.T.5
  • 57
    • 34347358646 scopus 로고    scopus 로고
    • JNK signalling: A possible target to prevent neurodegeneration
    • DOI 10.2174/138161207780858384
    • Borsello, T., and, Forloni, G., (2007) JNK signalling: a possible target to prevent neurodegeneration. Curr. Pharm. Des. 13, 1875-1886. (Pubitemid 47010160)
    • (2007) Current Pharmaceutical Design , vol.13 , Issue.18 , pp. 1875-1886
    • Borsello, T.1    Forloni, G.2
  • 58
    • 78651075836 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: A point of convergence for the host inflammatory response
    • Wang, H., Brown, J., and, Martin, M., (2011) Glycogen synthase kinase 3: a point of convergence for the host inflammatory response. Cytokine 53, 130-140.
    • (2011) Cytokine , vol.53 , pp. 130-140
    • Wang, H.1    Brown, J.2    Martin, M.3
  • 59
    • 34247557490 scopus 로고    scopus 로고
    • The LDL receptor-related protein (LRP) family: An old family of proteins with new physiological functions
    • DOI 10.1080/07853890701214881, PII 777639280
    • May, P., Woldt, E., Matz, R. L., and, Boucher, P., (2007) The LDL receptor-related protein (LRP) family: an old family of proteins with new physiological functions. Ann. Med. 39, 219-228. (Pubitemid 46676481)
    • (2007) Annals of Medicine , vol.39 , Issue.3 , pp. 219-228
    • May, P.1    Woldt, E.2    Matz, R.L.3    Boucher, P.4
  • 60
    • 0025768860 scopus 로고
    • The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein
    • Uchida, Y., Takio, K., Titani, K., Ihara, Y., and, Tomonaga, M., (1991) The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron 7, 337-347.
    • (1991) Neuron , vol.7 , pp. 337-347
    • Uchida, Y.1    Takio, K.2    Titani, K.3    Ihara, Y.4    Tomonaga, M.5
  • 61
    • 12544250155 scopus 로고    scopus 로고
    • Expression of metallothionein-III and cell death in differentiated catecholaminergic neuronal cells
    • Higashi, Y., Asanuma, M., Miyazaki, I., and, Ogawa, N., (2004) Expression of metallothionein-III and cell death in differentiated catecholaminergic neuronal cells. Neurol. Res. 26, 671-676.
    • (2004) Neurol. Res. , vol.26 , pp. 671-676
    • Higashi, Y.1    Asanuma, M.2    Miyazaki, I.3    Ogawa, N.4
  • 62
    • 70350303312 scopus 로고    scopus 로고
    • Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors
    • Koumura, A., Kakefuda, K., Honda, A., Ito, Y., Tsuruma, K., et al. (2009) Metallothionein-3 deficient mice exhibit abnormalities of psychological behaviors. Neurosci. Lett. 467, 11-14.
    • (2009) Neurosci. Lett. , vol.467 , pp. 11-14
    • Koumura, A.1    Kakefuda, K.2    Honda, A.3    Ito, Y.4    Tsuruma, K.5
  • 63
    • 0036312669 scopus 로고    scopus 로고
    • Age-related changes in expression of metallothionein-III in rat brain
    • DOI 10.1016/S0168-0102(02)00057-3, PII S0168010202000573
    • Miyazaki, I., Asanuma, M., Higashi, Y., Sogawa, C. A., Tanaka, K., et al. (2002) Age-related changes in expression of metallothionein-III in rat brain. Neurosci. Res. 43, 323-333. (Pubitemid 34828233)
    • (2002) Neuroscience Research , vol.43 , Issue.4 , pp. 323-333
    • Miyazaki, I.1    Asanuma, M.2    Higashi, Y.3    Sogawa, C.A.4    Tanaka, K.-I.5    Ogawa, N.6
  • 64
    • 0028813921 scopus 로고
    • The N-terminal portion of growth inhibitory factor is sufficient for biological activity
    • Uchida, Y., and, Ihara, Y., (1995) The N-terminal portion of growth inhibitory factor is sufficient for biological activity. J. Biol. Chem. 270, 3365-3369.
    • (1995) J. Biol. Chem. , vol.270 , pp. 3365-3369
    • Uchida, Y.1    Ihara, Y.2
  • 65
    • 0032413587 scopus 로고    scopus 로고
    • Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease
    • DOI 10.1006/nbdi.1998.0203
    • Adlard, P. A., West, A. K., and, Vickers, J. C., (1998) Increased density of metallothionein I/II-immunopositive cortical glial cells in the early stages of Alzheimer's disease. Neurobiol. Dis. 5, 349-356. (Pubitemid 29037286)
    • (1998) Neurobiology of Disease , vol.5 , Issue.5 , pp. 349-356
    • Adlard, P.A.1    West, A.K.2    Vickers, J.C.3
  • 67
    • 77957774530 scopus 로고    scopus 로고
    • The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons
    • Chung, R. S., Howells, C., Eaton, E. D., Shabala, L., Zovo, K., et al. (2010) The native copper- and zinc-binding protein metallothionein blocks copper-mediated Abeta aggregation and toxicity in rat cortical neurons. PloS One 5, e12030.
    • (2010) PloS One , vol.5
    • Chung, R.S.1    Howells, C.2    Eaton, E.D.3    Shabala, L.4    Zovo, K.5
  • 70
    • 77956647381 scopus 로고    scopus 로고
    • Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease
    • Duce, J. A., Tsatsanis, A., Cater, M. A., James, S. A., Robb, E., et al. (2010) Iron-export ferroxidase activity of beta-amyloid precursor protein is inhibited by zinc in Alzheimer's disease. Cell 142, 857-867.
    • (2010) Cell , vol.142 , pp. 857-867
    • Duce, J.A.1    Tsatsanis, A.2    Cater, M.A.3    James, S.A.4    Robb, E.5
  • 71
    • 51449096179 scopus 로고    scopus 로고
    • Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: A mechanism sensitive to the Kunitz protease inhibitor
    • Costa, R., Ferreira-da-Silva, F., Saraiva, M. J., and, Cardoso, I., (2008) Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor. PloS One 3, e2899.
    • (2008) PloS One , vol.3
    • Costa, R.1    Ferreira-Da-Silva, F.2    Saraiva, M.J.3    Cardoso, I.4
  • 72
    • 0035831110 scopus 로고    scopus 로고
    • Metallothionein III is reduced in Alzheimer's disease
    • DOI 10.1016/S0006-8993(00)03196-6, PII S0006899300031966
    • Yu, W. H., Lukiw, W. J., Bergeron, C., Niznik, H. B., and, Fraser, P. E., (2001) Metallothionein III is reduced in Alzheimer's disease. Brain Res. 894, 37-45. (Pubitemid 32197596)
    • (2001) Brain Research , vol.894 , Issue.1 , pp. 37-45
    • Yu W.Haung1    Lukiw, W.J.2    Bergeron, C.3    Niznik, H.B.4    Fraser, P.E.5
  • 73
    • 33645756587 scopus 로고    scopus 로고
    • Metallothionein-3 and neuronal nitric oxide synthase levels in brains from the Tg2576 mouse model of Alzheimer's disease
    • Martin, B. L., Tokheim, A. M., McCarthy, P. T., Doms, B. S., Davis, A. A., et al. (2006) Metallothionein-3 and neuronal nitric oxide synthase levels in brains from the Tg2576 mouse model of Alzheimer's disease. Mol. Cell Biochem. 283, 129-137.
    • (2006) Mol. Cell Biochem. , vol.283 , pp. 129-137
    • Martin, B.L.1    Tokheim, A.M.2    McCarthy, P.T.3    Doms, B.S.4    Davis, A.A.5
  • 74
    • 0034811882 scopus 로고    scopus 로고
    • Metallothionein-III antagonizes the neurotoxic and neurotrophic effects of amyloid β peptides
    • DOI 10.1006/bbrc.2001.4594
    • Irie, Y., and, Keung, W. M., (2001) Metallothionein-III antagonizes the neurotoxic and neurotrophic effects of amyloid beta peptides. Biochem. Biophys. Res. Commun. 282, 416-420. (Pubitemid 32917885)
    • (2001) Biochemical and Biophysical Research Communications , vol.282 , Issue.2 , pp. 416-420
    • Irie, Y.1    Keung, W.M.2
  • 75
    • 77449146307 scopus 로고    scopus 로고
    • The role of zinc in the modulation of neuronal proliferation and apoptosis
    • Adamo, A. M., Zago, M. P., Mackenzie, G. G., Aimo, L., Keen, C. L., et al. The role of zinc in the modulation of neuronal proliferation and apoptosis. Neurotox. Res. 17, 1-14.
    • Neurotox. Res. , vol.17 , pp. 1-14
    • Adamo, A.M.1    Zago, M.P.2    MacKenzie, G.G.3    Aimo, L.4    Keen, C.L.5
  • 76
    • 67649771693 scopus 로고    scopus 로고
    • Metallothionein as an anti-inflammatory mediator
    • Inoue, K., Takano, H., Shimada, A., and, Satoh, M., (2009) Metallothionein as an anti-inflammatory mediator. Mediators Inflamm. 2009, 101659.
    • (2009) Mediators Inflamm. , vol.2009 , pp. 101659
    • Inoue, K.1    Takano, H.2    Shimada, A.3    Satoh, M.4
  • 78
    • 27144457812 scopus 로고    scopus 로고
    • Molecular mechanisms of lipoprotein receptor signalling
    • DOI 10.1007/s00018-005-5231-z
    • May, P., Herz, J., and, Bock, H. H., (2005) Molecular mechanisms of lipoprotein receptor signalling. Cell Mol. Life Sci. 62, 2325-2338. (Pubitemid 41500548)
    • (2005) Cellular and Molecular Life Sciences , vol.62 , Issue.19-20 , pp. 2325-2338
    • May, P.1    Herz, J.2    Bock, H.H.3


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