Structural differences in the osteocyte network between the calvaria and long bone revealed by three-dimensional fluorescence morphometry, possibly reflecting distinct mechano-adaptations and sensitivities

Biochemical and Biophysical Research Communications

Volumn 417, Issue 2, 2012, Pages 765-770

  Himeno Ando, Akiko ^a   Izumi, Yuichi ^a   Yamaguchi, Akira ^a   Iimura, Tadahiro ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Fluorescence imaging; Morphometry; Osteocyte; Shear stress

Indexed keywords

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BONE DEMINERALIZATION; BONE STRUCTURE; CALVARIA; CONTROLLED STUDY; CYTOPLASM; FLUORESCENCE MICROSCOPY; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOCYTE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; THREE DIMENSIONAL FLUORESCENCE MORPHOMETRY; TIBIA;

ANIMALS; BONE AND BONES; MECHANOTRANSDUCTION, CELLULAR; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; OSTEOCYTES; SKULL;

EID: 84855858086     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.12.031     Document Type: Article

References (29)

1. Bonewald L.F. Osteocyte messages from a bony tomb. Cell Metab. 2007, 5:410-411.
2. Bonewald L.F. Osteocytes as dynamic multifunctional cells. Ann. NY Acad. Sci. 2007, 1116:281-290.
3. Bonewald L.F. The amazing osteocyte. J. Bone Miner Res. 2011, 26:229-238.
4. Bonewald L.F., Johnson M.L. Osteocytes, mechanosensing and Wnt signaling. Bone 2008, 42:606-615.
5. Tatsumi S., Ishii K., Amizuka N., Li M., Kobayashi T., Kohno K., Ito M., Takeshita S., Ikeda K. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab. 2007, 5:464-475.
6. Cowin S.C., Moss-Salentijn L., Moss M.L. Candidates for the mechanosensory system in bone. J. Biomech. Eng. 1991, 113:191-197.
7. Burger E.H., Klein-Nulend J. Mechanotransduction in bone-role of the lacuno-canalicular network. FASEB J. 1999, 13 Suppl:S101-S112.
8. Nakashima T., Hayashi M., Fukunaga T., Kurata K., Oh-Hora M., Feng J.Q., Bonewald L.F., Kodama T., Wutz A., Wagner E.F., Penninger J.M., Takayanagi H. Evidence for osteocyte regulation of bone homeostasis through RANKL expression. Nat. Med. 2011, 17:1231-1234.
9. Xiong J., Onal M., Jilka R.L., Weinstein R.S., Manolagas S.C., O'Brien C.A. Matrix-embedded cells control osteoclast formation. Nat. Med. 2011, 17:1235-1241.
10. Lin C., Jiang X., Dai Z., Guo X., Weng T., Wang J., Li Y., Feng G., Gao X., He L. Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J. Bone Miner. Res. 2009, 24:1651-1661.
11. Fukumoto S., Martin T.J. Bone as an endocrine organ. Trends Endocrinol. Metab. 2009, 20:230-236.
12. Piekarski K., Munro M. Transport mechanism operating between blood supply and osteocytes in long bones. Nature 1977, 269:80-82.
13. Han Y., Cowin S.C., Schaffler M.B., Weinbaum S. Mechanotransduction and strain amplification in osteocyte cell processes. Proc. Natl. Acad. Sci. USA 2004, 101:16689-16694.
14. Anderson E.J., Kaliyamoorthy S., Iwan J., Alexander D., Knothe Tate M.L. Nano-microscale models of periosteocytic flow show differences in stresses imparted to cell body and processes. Ann. Biomed. Eng. 2005, 33:52-62.
15. You L., Cowin S.C., Schaffler M.B., Weinbaum S. A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix. J. Biomech. 2001, 34:1375-1386.
16. You L.D., Weinbaum S., Cowin S.C., Schaffler M.B. Ultrastructure of the osteocyte process and its pericellular matrix. Anat. Rec. A Discov. Mol. Cell Evol. Biol. 2004, 278:505-513.
17. Petrtyl M., Hert J., Fiala P. Spatial organization of the haversian bone in man. J. Biomech. 1996, 29:161-169.
18. R. Hillam, M. Jackson, A. Goodship, and T. Skerry, Comparison of physiological strains in the human skull and tibia, Bone 19 (1) (1996) 686-686.
19. Lambert K.L. The weight-bearing function of the fibula. A strain gauge study. J. Bone Joint. Surg. Am. 1971, 53:507-513.
20. Wang N., Butler J.P., Ingber D.E. Mechanotransduction across the cell surface and through the cytoskeleton. Science 1993, 260:1124-1127.
21. Chen C.S., Tan J., Tien J. Mechanotransduction at cell-matrix and cell-cell contacts. Annu. Rev. Biomed. Eng. 2004, 6:275-302.
22. Cao L., Moriishi T., Miyazaki T., Iimura T., Hamagaki M., Nakane A., Tamamura Y., Komori T., Yamaguchi A. Comparative morphology of the osteocyte lacunocanalicular system in various vertebrates. J. Bone Miner. Metab. 2011.
23. Vatsa A., Breuls R.G., Semeins C.M., Salmon P.L., Smit T.H., Klein-Nulend J. Osteocyte morphology in fibula and calvaria - is there a role for mechanosensing?. Bone 2008, 43:452-458.
24. Sugawara Y., Ando R., Kamioka H., Ishihara Y., Honjo T., Kawanabe N., Kurosaka H., Takano-Yamamoto T., Yamashiro T. The three-dimensional morphometry and cell-cell communication of the osteocyte network in chick and mouse embryonic calvaria. Calcif. Tissue Int. 2011, 88:416-424.
25. Sugawara Y., Kamioka H., Honjo T., Tezuka K., Takano-Yamamoto T. Three-dimensional reconstruction of chick calvarial osteocytes and their cell processes using confocal microscopy. Bone 2005, 36:877-883.
26. Hirose S., Li M., Kojima T., de Freitas P.H., Ubaidus S., Oda K., Saito C., Amizuka N. A histological assessment on the distribution of the osteocytic lacunar canalicular system using silver staining. J. Bone Miner. Metab. 2007, 25:374-382.
27. Adachi T., Aonuma Y., Taira K., Hojo M., Kamioka H. Asymmetric intercellular communication between bone cells: propagation of the calcium signaling. Biochem. Biophys. Res. Commun. 2009, 389:495-500.
28. Iimura T., Nakane A., Sugiyama M., Sato H., Makino Y., Watanabe T., Takagi Y., Numano R., Yamaguchi A. A fluorescence spotlight on the clockwork development and metabolism of bone. J. Bone Miner. Metab. 2011.
29. van Hove R.P., Nolte P.A., Vatsa A., Semeins C.M., Salmon P.L., Smit T.H., Klein-Nulend J. Osteocyte morphology in human tibiae of different bone pathologies with different bone mineral density - is there a role for mechanosensing?. Bone 2009, 45:321-329.