Presence of intratumoral stem cells in breast cancer patients with or without BRCA germline mutations

Current Cancer Drug Targets

Volumn 12, Issue 1, 2012, Pages 44-50

  Singer, C F ^a   Zabkova, P ^a   Rappaport, C ^a   Muhr, D ^a   Pfeiler, G ^a   Gschwantler Kaulich, D ^a   Fink Retter, A ^a   Staudigl, C ^a   Walter, I ^b   Hudelist, G ^a,c   Spiess, A C ^a   Kubista, E ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF VETERINARY MEDICINE   (Austria)

^c Department of Obstetrics and Gynaecology ^*  (Austria)

Author keywords

ALDH 1; BRCA carrier; Breast cancer; Cancer stem cell

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER PATIENT; CANCER STEM CELL; CANCER TISSUE; CELL ISOLATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DISEASE SEVERITY; FEMALE; GENE MUTATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MAMMARY STEM CELL; METASTASIS; OVERALL SURVIVAL; PHENOTYPE;

ADULT; AGED; AGED, 80 AND OVER; BRCA1 PROTEIN; BRCA2 PROTEIN; BREAST NEOPLASMS; COHORT STUDIES; FEMALE; GERM-LINE MUTATION; HUMANS; ISOENZYMES; MIDDLE AGED; NEOPLASTIC STEM CELLS; RETINAL DEHYDROGENASE;

EID: 84855851095     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/156800912798888938     Document Type: Article

References (26)

1. Reya, T.; Morrison, S. J.; Clarke, M. F.; Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature 2001, 1, 105-111.
2. Smalley, M.; Ashworth, A. Stem cells and breast cancer: A field in transit. Nat. Rev. Cancer 2003,11, 832-844.
3. Cobaleda, C.; Cruz, J. J.; González-Sarmiento, R.; Sánchez-García, I.; Pérez-Losada, J. The emerging picture of human breast cancer as a stem cell-based disease. Stem Cell Rev. 2008, 4, 67-79.
4. Dontu, G.; Al-Hajj, M.; Abdallah, W. M.; Clarke, M. F.; Wicha, M. S. Stem cells in normal breast development and breast cancer. Cell Prolif. 2003, 36 (Suppl 1), 59-72.
5. Croker, A. K.; Allan, A. L. Cancer stem cells: implications for the progression and treatment of metastatic disease. J. Cell Mol. Med. 2008, 12, 374-390.
6. Martínez-Climent, J. A.; Andreu, E. J.; Prosper, F. Somatic stem cells and the origin of cancer. Clin. Transl. Oncol. 2006, 8, 647-663.
7. Atchley, D. P.; Albarracin, C. T.; Lopez, A.; Valero, V.; Amos, C. I.; Gonzalez-Angulo, A. M.; Hortobagyi, G. N.; Arun, B. K. Clinical and pathologic characteristics of patients with BRCApositive and BRCA-negative breast cancer. J. Clin. Oncol. 2008, 26, 4282-4288.
8. Liu, S.; Ginestier, C.; Charafe-Jauffret, E.; Foco, H.; Kleer, C. G.; Merajver, S. D.; Dontu, G.; Wicha, M. S. BRCA1 regulates human mammary stem/progenitor cell fate. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 1680-1685.
9. Ginestier, C.; Hur, M. H.; Charafe-Jauffret, E.; Monville, F.; Dutcher, J.; Brown, M.; Jacquemier, J.; Viens, P.; Kleer, C. G.; Liu, S.; Schott, A.; Hayes, D.; Birnbaum, D.; Wicha, M. S.; Dontu, G. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell. 2007, 15, 555-567.
10. Croker, A. K.; Goodale, D.; Chu, J.; Postenka, C.; Hedley, B. D.; Hess, D. A.; Allan, A. L. High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability. J. Cell. Mol. Med. 2009, 13, 2236-2252
11. Hogervorst, F. B.; Cornelis, R. S.; Bout, M.; van Vliet, M.; Oosterwijk, J. C.; Olmer, R.; Bakker, B.; Klijn, J. G.; Vasen, H. F.; Meijers-Heijboer, H. Nat. Genet. 1995, 10, 208-212.
12. Woodward, W. A.; Sulman, E. P. Cancer stem cells: markers or biomarkers? Cancer Metastasis Rev. 2008, 27, 459-470.
13. Ashkenazi, R.; Jackson, T. L.; Dontu, G.; Wicha, M. S. Breast cancer stem cells-research opportunities utilizing mathematical modeling. Stem Cell Rev. 2007, 3, 176-182.
14. Polyak, K. Breast cancer stem cells: a case of mistaken identity? Stem Cell Rev. 2007, 3, 107-109.
15. Singh, S. K.; Hawkins, C.; Clarke, I. D.; Squire, J. A.; Bayani, J.; Hide, T.; Henkelman, R. M.; Cusimano, M. D.; Dirks, P. B. Identification of human brain tumour initiating cells. Nature, 2004, 432, 396-401.
16. Ricci-Vitiani, L.; Lombardi, D. G.; Pilozzi, E.; Biffoni, M.; Todaro, M.; Peschle, C.; De Maria, R. Identification and expansion of human colon-cancer-initiating cells. Nature, 2007, 445, 111-115.
17. Al-Hajj, M.; Wicha, M. S.; Benito-Hernandez, A.; Morrison, S. J.; Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 3983-3988.
18. Balic, M.; Lin, H.; Young, L.; Hawes, D.; Giuliano, A.; McNamara, G.; Datar, R. H.; Cote, R. J. Most early disseminated cancer cells detected in bone marrow of breast cancer patients have a putative breast cancer stem cell phenotype. Clin. Cancer Res. 2006, 12, 5615-5621.
19. Chute, J. P.; Muramoto, G. G.; Whitesides, J.; Colvin, M.; Safi, R.; Chao, N. J.; McDonnell, D. P. Inhibition of aldehyde dehydrogenase and retinoid signaling induces the expansion of human hematopoietic stem cells. Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 11707-11712.
20. Balicki, D. Moving forward in human mammary stem cell biology and breast cancer prognostication using ALDH1. Cell Stem Cell 2007, 1: 485-487.
21. Russo, J.; Balogh, G. A.; Chen, J.; Fernandez, S. V.; Fernbaugh, R.; Heulings, R.; Mailo, D. A.; Moral, R.; Russo, P. A.; Sheriff, F.; Vanegas, J. E.; Wang, R.; Russo, I. H. The concept of stem cell in the mammary gland and its implication in morphogenesis, cancer and prevention. Front. Biosci. 2006, 11, 151-172.
22. Sreerama, L.; Sladek, N. E. Cellular levels of class 1 and class 3 aldehyde dehydrogenases and certain other drug-metabolizing enzymes in human breast malignancies. Clin. Cancer Res. 1997, 11, 1901-1914.
23. Liu, S.; Ginestier, C.; Charafe-Jauffret, E.; Foco, H.; Kleer, C. G.; Merajver, S. D.; Dontu, G.; Wicha, M. S. BRCA1 regulates human mammary stem/progenitor cell fate. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 1680-1685.
24. Vassilopoulos, A.; Wang, R. H.; Petrovas, C.; Ambrozak, D.; Koup, R.; Deng, C. X. Identification and characterization of cancer initiating cells from BRCA1 related mammary tumors using markers for normal mammary stem cells. Int. J. Biol. Sci. 2008, 4, 133-142.
25. Bradley, A.; Medina, D. Introduction: BRCA1 and BRCA2 in mammary gland development and tumorigenesis. J. Mammary Gland Biol. Neoplasia 1998, 3, 363-364.
26. Wright, M. H.; Calcagno, A. M.; Salcido, C. D.; Carlson, M. D.; Ambudkar, S. V.; Varticovski, L. Brca1 breast tumors contain distinct CD44+/CD24-and CD133+ cells with cancer stem cell characteristics. Breast Cancer Res. 2008, 10, R10.