STK39 is an independent risk factor for male hypertension in Han Chinese

International Journal of Cardiology

Volumn 154, Issue 2, 2012, Pages 122-127

  Chen, Li Yan ^a   Zhao, Wei Hua ^a   Tian, Wen ^a   Guo, Jian ^b   Jiang, Feng ^c   Jin, Li Juan ^c   Sun, Ying Xian ^a   Chen, Kai Ming ^a   An, Li Li ^a   Li, Guo Dong ^a   Li, Qing ^a   Li, Yang ^b   Wu, Chong ^b   Zhao, Ling ^b   Wang, Wen Jing ^b   Zheng, Gu Yan ^b   Li, Bing ^c   Li, Xue Qi ^c   Hu, Jian ^a   Tian, Xiao Li ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b PEKING UNIVERSITY   (China)

^c HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Gene gene interactions; Gene risk factors; Genetics; Han Chinese; Hypertension; STK39

Indexed keywords

ADULT; AGE DISTRIBUTION; ALCOHOL CONSUMPTION; ARTICLE; CHINESE; ESSENTIAL HYPERTENSION; GENDER; GENE; GENE FREQUENCY; GENE INTERACTION; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; OXSR1 GENE; PREVALENCE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SLC12A3 GENE; SMOKING; STK39 GENE;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; CHINA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN-SERINE-THREONINE KINASES; RISK FACTORS; SEX DISTRIBUTION;

EID: 84855840364     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2010.09.007     Document Type: Article

References (37)

1. P.K. Whelton Epidemiology of hypertension Lancet 344 1994 101 106 (Pubitemid 24214139)
2. P.M. Kearney, M. Whelton, K. Reynolds, P. Muntner, P.K. Whelton, and J. He Global burden of hypertension: analysis of worldwide data Lancet 365 2005 217 223 (Pubitemid 40138015)
3. M. Arici, C. Turgan, and B. Altun Hypertension incidence in Turkey (HinT): a population-based study J Hypertens 28 2010 240 244
4. F.B. Hu, and M.J. Stampfer Insulin resistance and hypertension: the chicken-egg question revisited Circulation 112 2005 1678 1680 (Pubitemid 41368140)
5. M.O. Tanira, and K.A. Al Balushi Genetic variations related to hypertension: a review J Hum Hypertens 19 2005 7 19
6. S. Newhouse, M. Farrall, and C. Wallace Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion PLoS ONE 4 2009 e5003
7. M. Das, S. Pal, and A. Ghosh Angiotensin converting enzyme gene polymorphism (insertion/deletion) and hypertension in adult Asian Indians: a population-based study from Calcutta, India Hum Biol 80 2008 303 312
8. C. Newton-Cheh, T. Johnson, and V. Gateva Genome-wide association study identifies eight loci associated with blood pressure Nat Genet 41 2010 666 676
9. D. Levy, G.B. Ehret, and K. Rice Genome-wide association study of blood pressure and hypertension Nat Genet 41 2009 677 687
10. E.L. Riddle, B.K. Rana, and K.K. Murthy Polymorphisms and haplotypes of the regulator of G protein signaling-2 gene in normotensives and hypertensives Hypertension 47 2006 415 420 (Pubitemid 43740284)
11. J. Yang, K. Kamide, and Y. Kokubo Genetic variations of regulator of G-protein signaling 2 in hypertensive patients and in the general population J Hypertens 23 2005 1497 1505 (Pubitemid 41104821)
12. S. Sõber, E. Org, and K. Kepp Targeting 160 candidate genes for blood pressure regulation with a genome-wide genotyping array PLoS ONE 4 2009 e6034
13. N.D. Fisher, C. Ferri, and C. Bellini Age, gender, and non-modulation. A sexual dimorphism in essential hypertension Hypertension 29 1997 980 985 (Pubitemid 27152469)
14. K. Dasgupta, J. O'Loughlin, and S. Chen Emergence of sex differences in prevalence of high systolic blood pressure: analysis of a longitudinal adolescent cohort Circulation 114 2006 2663 2670 (Pubitemid 44967350)
15. N.K. Wenger Hypertension and other cardiovascular risk factors in women Am J Hypertens 8 1995 94 99
16. B.K. Rana, P.A. Insel, and S.H. Payne Population-based sample reveals gene-gender interactions in blood pressure in White Americans Hypertension 49 2007 96 106 (Pubitemid 46360347)
17. Y. Wang, J.R. O'Connell, and P.F. McArdle From the cover: whole-genome association study identifies STK39 as a hypertension susceptibility gene Proc Natl Acad Sci U S A 106 2009 226 231
18. - cotransporter by the WNK-regulated kinases SPAK and OSR1 J Cell Sci 121 2008 675 684 (Pubitemid 351524166)
19. X.L. Tian, and Q.K. Wang Generation of transgenic mice for cardiovascular research Methods Mol Med 129 2006 69 81
20. Y. Li, W.J. Wang, and H. Cao Genetic association of FOXO1A and FOXO3A with longevity trait in Han Chinese populations Hum Mol Genet 18 2009 4897 4904
21. M.S. Cunnington, C. Kay, and P.J. Avery STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression BMC Med Genet 10 2009 135
22. D.T. Lackland, B.M. Egan, and W.K. Mountford Thirty-year Survival for Black and White Hypertensive Individuals in the Evans County Heart Study and the Hypertension Detection and Follow-up Program J Am Soc Hypertens 2 2008 448 454
23. K. Reynolds, D. Gu, and P. Muntner A population-based, prospective study of blood pressure and risk for end-stage renal disease in China J Am Soc Nephrol 18 2007 1928 1935 (Pubitemid 46870330)
24. U. Ganten, G. Schroder, M. Witt, F. Zimmermann, D. Ganten, and G. Stock Sexual dimorphism of blood pressure in spontaneously hypertensive rats: effects of anti-androgen treatment J Hypertens 7 1989 721 726 (Pubitemid 19230550)
25. D.B. Langille, M.R. Joffres, K.M. MacPherson, P. Andreou, S.A. Kirkland, and D.R. MacLean Prevalence of risk factors for cardiovascular disease in Canadians 55 to 74 years of age: results from the Canadian Heart Health Surveys, 1986-1992 CMAJ 161 8 Suppl 1999 S3 S9
26. E. Méndez-Chacón, C. Santamaría-Ulloa, and L. Rosero-Bixby Factors associated with hypertension prevalence, unawareness and treatment among Costa Rican elderly BMC Public Health 8 2008 275
27. T.G. Pickering Mental stress as a causal factor in the development of hypertension and cardiovascular disease Curr Hypertens Rep 3 2001 249 254
28. Y. Ruixing, W. Jinzhen, P. Shangling, L. Weixiong, Y. Dezhai, and C. Yuming Sex differences in environmental and genetic factors for hypertension Am J Med 121 2008 811 819
29. J.V. Gainer, M.S. Lipkowitz, and C. Yu Association of a CYP4A11 variant and blood pressure in black men J Am Soc Nephrol 19 2008 1606 1612
30. K.L. Ong, R.Y. Leung, and L.Y. Wong Association of a polymorphism in the lipin 1 gene with systolic blood pressure in men Am J Hypertens 21 2008 539 545 (Pubitemid 351589675)
31. W. Zhao, Y. Wang, and L. Wang Gender-specific association between the kininogen 1 gene variants and essential hypertension in Chinese Han population J Hypertens 27 2009 484 490
32. V.R. Holla, F. Adas, and J.D. Imig Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension Proc Natl Acad Sci U S A 98 2001 5211 5216 (Pubitemid 32397108)
33. H. Qi, Y. Labrie, J. Grenier, A. Fournier, C. Fillion, and C. Labrie Androgens induce expression of SPAK, a STE20/SPS1-related kinase, in LNCaP human prostate cancer cells Mol Cell Endocrinol 182 2001 181 192 (Pubitemid 32758771)
34. A.M. Traish, F. Saad, and A. Guay The dark side of testosterone deficiency: II. Type 2 diabetes and insulin resistance J Androl 30 2009 23 32
35. R. Fogari, P. Preti, and A. Zoppi Serum testosterone levels and arterial blood pressure in the elderly Hypertens Res 28 2005 625 630 (Pubitemid 41601034)
36. S.Y. Wong, D.C. Chan, A. Hong, and J. Woo Prevalence of and risk factors for androgen deficiency in middle-aged men in Hong Kong Metabolism 55 2006 1488 1494 (Pubitemid 44537346)
37. A.J. Coats Ethical authorship and publishing Int J Cardiol 131 2009 149 150